Citalopram withdrawal symptoms
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Citalopram Withdrawal Symptoms: Overview and Prevalence
Citalopram, a selective serotonin reuptake inhibitor (SSRI), can cause withdrawal symptoms when stopped abruptly. These symptoms are often called SSRI withdrawal or discontinuation syndrome. Research shows that while all SSRIs can cause withdrawal symptoms, the severity and frequency can vary between medications. For citalopram specifically, most withdrawal symptoms are mild and short-lived, and there is no clear link between the dose taken before stopping and the likelihood of experiencing symptoms. Many symptoms may actually reflect a return of depression or anxiety rather than true withdrawal effects 16.
Common Citalopram Withdrawal Symptoms
Typical withdrawal symptoms from citalopram can include dizziness, nausea, muscle aches, anxiety, irritability, and central nervous system effects. These symptoms usually appear within a few days of stopping the medication and can last for several weeks, even if the drug is tapered gradually. However, the intensity and duration can vary widely among individuals 168.
Uncommon and Rare Withdrawal Effects
In rare cases, citalopram withdrawal can lead to unusual symptoms. For example, there are reports of withdrawal-induced mania or hypomania, where patients experience increased energy, irritability, and other manic symptoms after stopping citalopram. These cases are uncommon and may be underrecognized in clinical practice . Another rare effect is premature ejaculation, which has been observed in some patients after discontinuing citalopram, even when the drug is tapered slowly . Additionally, abrupt cessation has been linked to new-onset hypertension, which resolved after restarting citalopram .
Distinguishing Withdrawal from Relapse
It is important to note that some symptoms experienced after stopping citalopram may be mistaken for a relapse of depression or anxiety. Studies highlight that withdrawal symptoms can be confused with the return of the original illness, making it crucial for clinicians to carefully assess patients during discontinuation 146.
Clinical Recommendations for Citalopram Discontinuation
Gradual tapering of citalopram is generally advised to minimize withdrawal symptoms and avoid severe or persistent effects. Clinicians should monitor patients closely during and after discontinuation, specifically asking about withdrawal symptoms, including those that may not be spontaneously reported, such as sexual side effects 678.
Conclusion
Citalopram withdrawal symptoms are generally mild and short-lived but can occasionally be more severe or unusual. Symptoms can include dizziness, nausea, anxiety, irritability, and, rarely, mania, sexual dysfunction, or hypertension. Gradual tapering and close monitoring are recommended to reduce the risk and impact of withdrawal symptoms. Distinguishing between withdrawal and relapse is essential for appropriate patient care 124678.
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