Collagen hydrolysate supplement
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Benefits of Collagen Hydrolysate Supplements
Introduction to Collagen Hydrolysate Supplements
Collagen hydrolysate supplements have gained popularity for their potential benefits in improving skin health, joint function, and bone metabolism. These supplements contain bioactive peptides that are believed to enhance various physiological functions. This article synthesizes recent research findings on the efficacy and safety of collagen hydrolysate supplements.
Skin Health: Improved Moisture, Elasticity, and Reduced Wrinkles
Enhanced Skin Moisture and Elasticity
Several studies have demonstrated that collagen hydrolysate supplements can significantly improve skin moisture and elasticity. A randomized double-blind placebo-controlled clinical trial showed that collagen hydrolysate with a higher content of bioactive peptides, such as Pro-Hyp and Hyp-Gly, led to significant improvements in facial skin moisture, elasticity, wrinkles, and roughness compared to a placebo 1. Another study confirmed these findings, showing that oral supplementation with collagen peptides rich in X-Hyp or X-Hyp-Gly significantly increased skin elasticity and collagen synthesis in the dermis 2.
Reduction in Wrinkles and Skin Roughness
The intake of collagen peptides has also been associated with a reduction in skin wrinkling and roughness. A study involving the administration of 1650 mg per day of collagen peptide NS for 12 weeks reported significant improvements in skin hydration, elasticity, desquamation, and wrinkling in women aged 30 to 60 years 3. These results suggest that collagen hydrolysate supplements can effectively enhance skin appearance and health.
Joint Health: Alleviation of Joint Pain
Relief from Activity-Related Joint Pain
Collagen hydrolysate supplements have shown promise in reducing joint pain, particularly in physically active individuals. A 24-week study on athletes with activity-related joint pain found that those who consumed collagen hydrolysate experienced significant reductions in joint pain at rest, while walking, standing, and during other activities compared to a placebo group 8. This suggests that collagen hydrolysate can support joint health and potentially reduce the risk of joint deterioration in high-risk groups.
Improvement in Osteoarthritis Symptoms
In patients with osteoarthritis, collagen hydrolysate supplementation has been shown to exert an anabolic effect on cartilage tissue. A study involving subjects with joint pain reported that 51.6% of participants in the collagen hydrolysate group experienced a clinically significant improvement in joint pain after six months, compared to 36.5% in the placebo group 5. These findings indicate that collagen hydrolysate may be beneficial for individuals suffering from osteoarthritis.
Bone Health: Effects on Bone Metabolism
Preservation of Bone Mass and Strength
Research on the effects of collagen hydrolysate on bone health has yielded mixed results. A study on ovariectomized rats demonstrated that a high dosage of collagen hydrolysate significantly improved the compositional and biomechanical characteristics of vertebrae, suggesting a potential benefit in preserving bone mass and strength 7. However, a clinical trial on postmenopausal women with low bone mineral density found no significant effects of collagen hydrolysate supplementation on biochemical markers of bone metabolism 9. These discrepancies highlight the need for further research to fully understand the impact of collagen hydrolysate on bone health.
Conclusion
Collagen hydrolysate supplements have shown potential benefits in improving skin health, alleviating joint pain, and possibly supporting bone health. The bioactive peptides in these supplements, such as Pro-Hyp and Hyp-Gly, play a crucial role in enhancing skin moisture, elasticity, and reducing wrinkles. Additionally, collagen hydrolysate may help reduce joint pain in physically active individuals and those with osteoarthritis. While some studies suggest benefits for bone health, further research is needed to confirm these effects. Overall, collagen hydrolysate supplements appear to be a promising option for enhancing various aspects of health and well-being.
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Most relevant research papers on this topic
Ingestion of bioactive collagen hydrolysates enhance facial skin moisture and elasticity and reduce facial ageing signs in a randomised double-blind placebo-controlled clinical study.
Collagen hydrolysates with higher content of bioactive collagen peptides significantly improve facial skin moisture, elasticity, wrinkles, and roughness compared to placebo.
RCT
Rigorous Journal
Highly CitedThe effect of oral supplements containing collagen peptides rich in X-Hyp or X-Hyp-Gly compared with normal collagen hydrolysates on skin elasticity and collagen holes: a randomised double-blind clinical study.
Oral supplements containing collagen peptides rich in X-Hyp or X-Hyp-Gly significantly improve skin elasticity and collagen synthesis compared to normal collagen hydrolysates.
RCTOral intake of collagen peptide NS improves hydration, elasticity, desquamation, and wrinkling in human skin: a randomized, double-blinded, placebo-controlled study.
Oral intake of collagen peptide NS, containing Gly-Pro and Pro-Hyp, significantly improves skin hydration, elasticity, desquamation, and wrinkling in women aged 30 to 60 years without causing side effects.
RCTOral Ingestion of Collagen Hydrolysate Leads to the Transportation of Highly Concentrated Gly-Pro-Hyp and Its Hydrolyzed Form of Pro-Hyp into the Bloodstream and Skin.
Oral ingestion of collagen hydrolysate leads to the transport of highly concentrated Gly-Pro-Hyp and its hydrolyzed form into the bloodstream and skin, potentially benefiting skin aging treatment.
Non-RCTHighly CitedEffect of collagen hydrolysate in articular pain: a 6-month randomized, double-blind, placebo controlled study.
Collagen hydrolysate 1200 mg/day may increase the number of clinical responders (i.e. improvement of at least 20% on the VAS) compared to placebo in patients with joint pain.
RCTA collagen hydrolysate/milk protein-blend stimulates muscle anabolism equivalently to an isoenergetic milk protein-blend containing a greater quantity of essential amino acids in older men
A collagen hydrolysate/milk protein-blend stimulates muscle anabolism equivalently to an isoenergetic milk protein-blend containing a greater quantity of essential amino acids in older men.
RCT
Very Rigorous JournalA food supplement of hydrolyzed collagen improves compositional and biodynamic characteristics of vertebrae in ovariectomized rats.
Hydrolyzed collagen supplementation improves vertebral mass, protein content, and mechanical strength in ovariectomized rats, but may have the opposite effect in intact rats.
RCT24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain
Collagen hydrolysate significantly reduces activity-related joint pain in athletes without evidence of joint disease compared to placebo.
RCTHighly CitedEffect of dietary supplementation with collagen hydrolysates on bone metabolism of postmenopausal women with low mineral density.
Dietary supplementation with collagen hydrolysates did not significantly affect bone metabolism in postmenopausal women with low bone mineral density.
RCTA collagen-derived oligopeptide from Salmo Salar collagen hydrolysates restrains atherogenesis in ApoE-/- mice via targeting P2 Y12 receptor.
OG-5, a collagen-derived oligopeptide, effectively reduces atherosclerotic plaque formation in ApoE-/- mice without side effects, suggesting its potential as an effective diet supplement for prevention of atherogenesis and thrombotic diseases.
Non-RCT
Animal StudyRigorous Journal