Comparison of Mylanta and Maalox
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Antacid Comparison: Mylanta vs. Maalox – Acid Neutralizing Capacity and Effectiveness
Acid Neutralizing Capacity (ANC) of Mylanta and Maalox
Both Mylanta and Maalox are liquid antacids containing aluminum and magnesium hydroxide as their main active ingredients. Studies show that concentrated liquid forms of both Mylanta and Maalox have high acid-neutralizing capacities, with some formulations of Maalox (such as Maalox TC) and Mylanta (such as Mylanta-2 Extra Strength) ranking among the highest in ANC among Canadian antacid products . In Belgium, Mylanta-II liquid and tablets were found to have a higher ANC per unit dose compared to Maalox and other local antacids, although Maalox products also had relatively low sodium content .
Onset and Duration of Action in Heartburn Relief
When comparing the effects of Mylanta and Maalox on esophageal and gastric pH in patients with heartburn, both antacids rapidly increased esophageal pH after a meal, peaking at values between 7.0 and 7.4. The increase in esophageal pH was significant for both products, but the duration of this effect varied: Maalox (20 ml) maintained a higher pH for about 30 minutes, while Mylanta (20 ml) and a higher dose of Maalox (30 ml) extended this effect for at least 70 minutes . Interestingly, the antacid dose with the lowest ANC (Mylanta 20 ml) had a duration of action as long or longer than higher ANC doses, suggesting that ANC alone does not predict in vivo effectiveness .
Gastric pH and Reflux Episodes
Both antacids caused a modest increase in gastric pH, peaking at 2.9–3.1. However, only Mylanta (20 ml) significantly reduced the total number of reflux episodes and increased the total time that esophageal pH remained above 4, compared to placebo . This suggests that Mylanta may offer some additional benefit in reducing reflux episodes in heartburn patients.
Product Consistency and Dosage Considerations
Studies highlight that both Mylanta and Maalox offer high ANC with low dosage volumes, sodium, and calorie content, making them suitable for patients who need to limit sodium intake 23. However, there can be some lot-to-lot variation in ANC among liquid antacids, which may affect consistency . The minimum recommended dose for Mylanta-II liquid is 5 ml, while for Maalox it is 10 ml, resulting in a lower sodium content per dose for Mylanta-II .
Comparative Performance in In-Vitro Tests
In laboratory tests, both Mylanta and Maalox had lower acid-neutralizing capacity and slower onset of action compared to some other antacid products (such as Riopan), but their duration of acid neutralization was similar, with Maalox and Mylanta providing a moderate duration of action above pH 3 .
Conclusion
Mylanta and Maalox are both effective liquid antacids with similar active ingredients and high acid-neutralizing capacities. Mylanta may offer a longer duration of esophageal pH elevation and a greater reduction in reflux episodes compared to Maalox at standard doses, although both are effective for heartburn relief. ANC is not the sole predictor of clinical effectiveness, and both products are suitable for patients needing low sodium intake. Differences in onset, duration, and recommended dosing may guide individual product choice.
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