Complication dm
Searched over 200M research papers for "complication dm"
Summary
10 papers analyzed
These studies suggest that diabetes mellitus (DM) is associated with a wide range of complications including postoperative issues, oral health problems, higher risk of severe COVID-19 outcomes, diabetic retinopathy, erectile dysfunction, cardiovascular diseases, and impaired wound healing.
Not a yes or no question
To use the Consensus Meter, try asking a simple yes or no question
Research summarized with Copilot
Beta20 papers analyzed
Complications of Diabetes Mellitus: A Comprehensive Overview
Postoperative Complications in Diabetes Mellitus
Increased Risk of Postoperative Complications
Diabetes mellitus (DM) significantly increases the risk of postoperative complications across various types of surgeries. A meta-analysis involving over 3 million participants found that DM patients had a higher likelihood of experiencing any postoperative complication, with an odds ratio (OR) of 1.653. Insulin-dependent DM patients were at an even higher risk compared to non-insulin-dependent DM patients. Specific complications included infections, wound healing disorders, hematoma, renal insufficiency, myocardial infarction, reoperation, readmission, and death.
Impact on Lung Cancer Surgery Outcomes
In the context of lung cancer surgery, DM was found to be an independent predictor of postoperative complications and worse overall survival in patients undergoing resection for non-small cell lung cancer (NSCLC). Although DM did not significantly increase perioperative and lung cancer-related mortalities, it was associated with a higher incidence of postoperative complications and poorer overall survival.
Oral Complications in Diabetes Mellitus
Broad Spectrum of Oral Health Issues
DM is linked to a variety of oral health complications beyond the commonly discussed periodontitis. These include dental caries, dry mouth, oral mucosal lesions, oral cancer, taste disturbances, temporomandibular disorders, burning mouth syndrome, apical periodontitis, and peri-implant diseases. The pathogenesis involves metabolic and hemodynamic disturbances such as hyperglycemia, insulin resistance, dyslipidemia, hypertension, and immune dysfunction, which collectively contribute to these oral health issues.
Diabetic Retinopathy: A Major Concern
Prevalence and Risk Factors
Diabetic retinopathy (DR) is a leading cause of vision impairment and blindness among working-age adults globally. In China, the prevalence of any DR in DM patients was found to be 18.45%, with nonproliferative DR (NPDR) and proliferative DR (PDR) being 15.06% and 0.99%, respectively. Risk factors for DR include insulin treatment, elevated fasting blood glucose (FBG) levels, and higher HbA1c concentrations. Rural residents and those with longer DM duration were at higher risk.
Guidelines for Diabetic Eye Care
The International Council of Ophthalmology has provided comprehensive guidelines for DR screening, referral, and treatment, emphasizing the need for tailored public health strategies based on resource settings. These guidelines aim to prevent vision loss through timely and appropriate interventions, including laser photocoagulation and intravitreal injections.
Erectile Dysfunction in Diabetes Mellitus
Prevalence and Impact
Erectile dysfunction (ED) is a significant sexual dysfunction in men with DM, with a prevalence approximately 3.5 times higher than in non-DM men. Common risk factors include a sedentary lifestyle, overweight/obesity, and increased caloric consumption. While lifestyle changes can improve sexual function, specific treatments are often necessary.
Complications in COVID-19 Patients with Diabetes Mellitus
Increased Severity and Mortality
DM is associated with increased severity and mortality in COVID-19 patients. A meta-analysis revealed that DM patients had a higher risk of composite poor outcomes, including mortality, severe COVID-19, acute respiratory distress syndrome (ARDS), and disease progression. The association was influenced by age and hypertension, with younger patients and those without hypertension showing a stronger association.
Wound Healing Impairment in Diabetes Mellitus
Mechanisms of Poor Wound Closure
One of the major complications of DM is impaired wound healing, primarily due to decreased keratinocyte mobility in hyperglycemic conditions. This impairment hampers the re-epithelialization process, crucial for wound closure, leading to chronic wounds and increased susceptibility to infections.
Conclusion
Diabetes mellitus is associated with a wide range of complications affecting various organ systems. From increased postoperative risks and oral health issues to severe outcomes in COVID-19 and impaired wound healing, the impact of DM is profound and multifaceted. Effective management and tailored interventions are essential to mitigate these complications and improve the quality of life for individuals with DM.
Sources and full results
Most relevant research papers on this topic
