Does collagen help thinning hair

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The Role of Collagen in Addressing Thinning Hair

Introduction to Thinning Hair and Collagen

Thinning hair is a common concern that affects many individuals, leading to a search for effective treatments. Among various options, collagen has gained attention for its potential benefits in promoting hair health. This article explores the scientific evidence supporting the use of collagen for thinning hair.

Collagen and Hair Growth: Mechanisms and Benefits

Fish-Derived Collagen Peptides and Hair Regrowth

Fish-derived collagen peptides (CPs) have shown promising results in promoting hair growth. Studies have demonstrated that CPs enhance the proliferation of human dermal papilla cells (hDPCs) and improve hair regrowth in animal models. Specifically, CPs from Mozambique tilapia scales have been found to significantly enhance hair regrowth and upregulate hair growth factors such as IGF-1 and VEGF, while downregulating inhibitory factors like TGF-β1 23. These findings suggest that CPs can be effective in preventing hair loss and promoting hair regrowth.

Hydrolyzed Collagen and Hair Health

Hydrolyzed collagen (HC) has also been studied for its potential benefits in hair health. Oral supplementation with HC, along with other amino acids and minerals, has shown beneficial effects on hair growth. Although controlled data on the clinical efficacy of HC as an adjuvant to hair loss treatments are limited, its positive impact on nail and skin health suggests potential benefits for hair as well .

Type 17 Collagen and Hair Follicle Maintenance

Type 17 collagen plays a crucial role in maintaining hair follicle stem cells and preventing thinning hair. Research indicates that continuous expression of type 17 collagen in hair follicles is essential for stem cell maintenance. Chlorogenic acid, a compound that promotes the production of type 17 collagen, has been shown to enhance collagen production in human epidermal keratinocytes, suggesting a potential therapeutic approach for thinning hair .

Collagen VI and Hair Follicle Regeneration

Interestingly, the role of collagen VI in hair follicle growth has also been explored. While collagen VI is abundant in the skin and hair follicles, its absence has been found to delay hair cycling and growth under normal conditions. However, in the context of skin wounding, the lack of collagen VI promotes hair regrowth by activating the Wnt/β-catenin signaling pathway. This highlights the complex relationship between different types of collagen and hair follicle regeneration .

Natural Hair Supplements: Collagen's Popularity and Efficacy

The popularity of natural hair supplements, including collagen, has surged in recent years. Despite the growing interest, it is essential to rely on scientific evidence to substantiate the claims made by various products. While collagen supplements are widely marketed for hair regrowth, healthcare professionals should be informed about the evidence supporting their use to provide accurate guidance to individuals seeking natural therapies for thinning hair .

Conclusion

Collagen, particularly fish-derived collagen peptides and hydrolyzed collagen, shows promise in promoting hair growth and improving hair health. The mechanisms involve enhancing the proliferation of dermal papilla cells, upregulating hair growth factors, and maintaining hair follicle stem cells. While more controlled clinical studies are needed, the existing evidence supports the potential benefits of collagen supplementation for individuals experiencing thinning hair.

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Most relevant research papers on this topic

Efficacy and tolerability of an oral supplement containing amino acids, iron, selenium, and marine hydrolyzed collagen in subjects with hair loss (androgenetic alopecia, AGA or FAGA or telogen effluvium). A prospective, randomized, 3‐month, controlled, assessor‐blinded study

Oral supplementation with amino acids, iron, selenium, and marine hydrolyzed collagen may improve hair growth and overall health in individuals with hair loss conditions like androgenic alopecia and telogen effluvium.

RCT

2023·

7citations

·M. Milani et al.

Hair-Growth-Promoting Effects of the Fish Collagen Peptide in Human Dermal Papilla Cells and C57BL/6 Mice Modulating Wnt/β-Catenin and BMP Signaling Pathways

Fish collagen peptides from Mozambique tilapia scales can promote hair growth and prevent hair loss by enhancing human dermal papilla cell proliferation and modulating Wnt/-catenin and BMP signaling pathways.

2022·

23citations

·Su Bin Hwang et al.

Collagen Hydrolysate from the Scales of Mozambique Tilapia (Oreochromis mossambicus) Improve Hair and Skin Health by Alleviating Oxidative Stress and Inflammation and Promoting Hair Growth and Extracellular Matrix Factors

Fish-derived collagen hydrolysate from Mozambique tilapia scales improves hair and skin health by alleviating oxidative stress, promoting hair growth, and enhancing skin health, both in vitro and in vivo.

RCTAnimal Study

2023·

4citations

·Su Bin Hwang et al.

Promoting effect of type 17 collagen production by chlorogenic acid using PLGA nanoparticles in the human epidermal keratinocyte cell

PLGA nanoparticles encapsulating chlorogenic acid significantly increase type 17 collagen production in human epidermal keratinocytes, making them a potential tool for efficient skin care products.

In Vitro Study

2020·

6citations

·Takahiro Suzuki et al.

Lack of Collagen VI Promotes Wound-Induced Hair Growth.

Lack of collagen VI in hair follicles promotes wound-induced hair growth, suggesting it as a potential therapeutic target for hair loss and skin-related diseases.

Non-RCTAnimal Study

2015·

34citations

·Peiwen Chen et al.

Natural Hair Supplements: Biotin and Collagen

Biotin and collagen supplements are effective natural treatments for thinning hair, but patients should be aware of potential side effects and be aware of unsubstantiated claims on the market.

2023·

1citation

·S. A. Van Wicklin

Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis

Hair follicle aging is driven by the elimination of stem cells through COL17A1 proteolysis, leading to hair loss and follicle shrinkage in long-lived mammals.

Highly Cited

2016·

288citations

·H. Matsumura et al.

Formulation and Examination of Organic Oil and Shampoo from Fish Scales

Fish scale-based organic oil and shampoo are safe, natural, and effective in maintaining healthy hair and preventing hair loss and damage.

2019·

0citations

Oral intake of Bioactive Collagen Peptides in the improvement of skin and hair: clinical studies by instrumental measurements

Oral intake of 5g/day of collagen peptides significantly improves skin conditions and increases hair strength, particularly for aged hair.

2022·

2citations

·P. M. Maia Campos et al.

A Six-Month, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Safety and Efficacy of a Nutraceutical Supplement for Promoting Hair Growth in Women With Self-Perceived Thinning Hair.

Nutrafol® Women's Capsules effectively promote hair growth and overall hair quality in women with self-perceived thinning hair, addressing micro-inflammation, stress, and oxidative damage.

RCT

2018·

34citations

·G. Ablon et al.

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