Does ibuprofen cause constipation

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Does Ibuprofen Cause Constipation?

Introduction to Ibuprofen and Its Common Side Effects

Ibuprofen is a widely used non-steroidal anti-inflammatory drug (NSAID) known for its effectiveness in reducing inflammation and alleviating pain. However, like many medications, it comes with a range of potential side effects. Among these, gastrointestinal issues are particularly common, including stomach pain, heartburn, nausea, vomiting, gas, constipation, and diarrhea .

Association Between Ibuprofen and Constipation

Research has shown a clear association between the use of ibuprofen and the occurrence of constipation. A cross-sectional study conducted in Oppland County, Norway, aimed to identify the relationship between various drugs and gastrointestinal complaints, including constipation and diarrhea. The study found that the use of ibuprofen was significantly associated with an increased prevalence of constipation. Specifically, the study reported an excess drug-related prevalence of 5.3% for constipation among ibuprofen users .

Broader Context of Drug-Induced Gastrointestinal Issues

The same study also highlighted that the use of multiple medications (polypharmacy) further increased the risk of gastrointestinal issues, including both constipation and diarrhea. This suggests that individuals taking ibuprofen along with other medications may be at an even higher risk of experiencing these side effects .

Conclusion

In summary, ibuprofen is indeed associated with an increased risk of constipation. This side effect is part of a broader spectrum of gastrointestinal issues that can arise from the use of this common NSAID. Individuals using ibuprofen, especially those on multiple medications, should be aware of this potential side effect and consult healthcare providers if they experience significant gastrointestinal discomfort.

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Most relevant research papers on this topic

Improve the Role of Ibuprofen in the Biological Field: Short Review

Ibuprofen can provide relief from inflammation and pain, but its side effects can be reduced by synthesizing metal-Ibuprofen complexes and developing Ibuprofen-delivery systems.

Literature Review

2020·

0citations

·Baraa Watheq et al.

Constipation and diarrhoea - common adverse drug reactions? A cross sectional study in the general population

Drug use is associated with increased prevalence of constipation and diarrhoea in the general population, likely due to adverse drug reactions.

Observational Study

2011·

60citations

·G. S. Fosnes et al.

Quantifying the intensity of adverse events with ibuprofen and oxycodone: an observational cohort study

Oxycodone is associated with more frequent and higher-intensity adverse events, greater functional limitations, and higher pain scores compared to ibuprofen in children with acute fractures.

Observational StudyRigorous Journal

2022·

0citations

·Samina Ali et al.

Ibuprofen slows migration and inhibits bowel colonization by enteric nervous system precursors in zebrafish, chick and mouse.

Ibuprofen may increase Hirschsprung disease risk in genetically susceptible children by inhibiting enteric nervous system precursor migration and bowel colonization in zebrafish, mouse, and chick.

In Vitro Study

2016·

40citations

·E. Schill et al.

A double-blind placebo-controlled comparison of the efficacy and safety of 50, 100, and 200 micrograms of misoprostol QID in the prevention of ibuprofen-induced gastric and duodenal mucosal lesions and symptoms.

Misoprostol in both antisecretory (200- and 100-micrograms) and non-antisecretory (50-micrograms) doses protects gastric mucosa from ibuprofen-induced damage, but only in the duodenum, where acid suppression is

RCT

1989·

60citations

·Frank L. Lanza et al.

Aggravation of exercise-induced intestinal injury by Ibuprofen in athletes.

Ibuprofen consumption before exercise aggravates small intestinal injury and causes gut barrier dysfunction in healthy individuals, making it not harmless and should be discouraged.

Non-RCTVery Rigorous JournalHighly Cited

2012·

94citations

·K. van Wijck et al.

Ibuprofen hepatic encephalopathy, hepatomegaly, gastric lesion and gastric pentadecapeptide BPC 157 in rats.

BPC 157 effectively counteracts the adverse effects of chronic ibuprofen in rats, maintaining normal weight gain and no behavioral disturbances.

Non-RCTAnimal StudyRigorous Journal

2011·

58citations

·Spomenko Ilić et al.

Gastrointestinal safety and tolerance of ibuprofen at maximum over‐the‐counter dose

Ibuprofen at maximum over-the-counter dose (1200 mg/day for 10 days) is safe and well-tolerated, with rare gastrointestinal symptoms and bleeding.

Highly Cited

1999·

74citations

·G. Doyle et al.

A randomized trial measuring fecal blood loss after treatment with rofecoxib, ibuprofen, or placebo in healthy subjects.

In healthy subjects, treatment with rofecoxib at 2 to 4 times the doses recommended for osteoarthritis treatment caused significantly less fecal blood loss than a therapeutic dose of ibuprofen and was equivalent to placebo.

RCTHighly Cited

2000·

86citations

·R. Hunt et al.

Commercially viable resolution of ibuprofen.

This study successfully isolated (S)-ibuprofen with a greater than 99% enantiomeric excess using environmentally friendly enantioselective esterification and hydrolysis methods, making it commercially viable for NSAID production.

2009·

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·D. Chávez-Flores et al.

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