Does jardiance cause diarrhea

Pro Research Analysisby

Searched over 200M research papers

Analyzed relevant papers

Does Jardiance Cause Diarrhea?

Introduction to Jardiance (Empagliflozin)

Jardiance, also known by its generic name empagliflozin, is a sodium-glucose co-transporter 2 (SGLT2) inhibitor. It is primarily used to manage blood glucose levels in patients with type 2 diabetes mellitus (T2DM) by reducing renal tubular glucose reabsorption. This mechanism helps lower blood glucose levels without stimulating insulin release. Jardiance is also known for its benefits in reducing cardiovascular events and slowing the progression of chronic kidney disease in T2DM patients .

Drug-Induced Diarrhea: General Mechanisms

Drug-induced diarrhea is a common side effect associated with various medications. The gastrointestinal tract can become dysregulated when exposed to certain drugs, leading to disruptions in mucosal permeability, transport, motility, and gut metabolism. These disruptions can result in different types of diarrhea, classified broadly into watery, inflammatory, and fatty stools. Treatment typically involves discontinuing the offending drug, although in some cases, diarrhea may resolve with continued use or through nonspecific agents like lomotil or loperamide .

Jardiance and Diarrhea: Evidence and Insights

While the provided data does not directly link Jardiance to causing diarrhea, it is important to consider the general mechanisms of drug-induced diarrhea. Given that many drugs can disrupt gastrointestinal function, it is plausible that Jardiance could potentially cause diarrhea in some patients. However, specific evidence directly associating Jardiance with diarrhea is not detailed in the provided abstracts.

Conclusion

In summary, while Jardiance is primarily noted for its benefits in managing blood glucose levels and reducing cardiovascular risks in T2DM patients, the potential for it to cause diarrhea cannot be entirely ruled out based on general knowledge of drug-induced gastrointestinal side effects. However, the provided data does not offer direct evidence linking Jardiance to diarrhea. Further research and clinical data would be necessary to establish a definitive connection.

Sources and full results

Most relevant research papers on this topic

A Case of Severe Metabolic Acidosis due to Jardiance-Induced Euglycemic Diabetic Ketoacidosis

Empagliflozin, a type 2 diabetes drug, can cause severe euglycemic diabetic ketoacidosis in patients with acute illness, decreased carbohydrate intake, or discontinuing insulin.

Case ReportRigorous Journal

2021·

2citations

·N. Dyatlova et al.

[Drug induced diarrhea].

Drug-induced diarrhea can be classified into watery, inflammatory, and fatty categories, and treatment varies depending on the drug and its mechanism of action.

2008·

59citations

·I. Morard et al.

Prevention of irinotecan induced diarrhea by probiotics: A randomized double blind, placebo controlled pilot study.

Probiotics are safe and may reduce the incidence and severity of gastrointestinal toxicity in colorectal cancer patients treated with irinotecan-based chemotherapy.

RCTHighly Cited

2015·

174citations

·M. Mego et al.

Antibiotic-Associated Diarrhea

Probiotics may reduce the risk of antibiotic-associated diarrhea, but more research is needed to confirm their safety and effectiveness.

Meta-AnalysisHighly Cited

2013·

310citations

·C. Varughese et al.

Mechanisms of Drug-Induced Diarrhoea in the Elderly

Drug-induced diarrhoea in the elderly can result from immune and nonimmune factors, disrupt gut motility, and disrupt colon defenses.

Highly Cited

1998·

76citations

·R. N. Ratnaike et al.

Treatment of diarrhea caused by Giardia intestinalis and Entamoeba histolytica or E. dispar: a randomized, double-blind, placebo-controlled study of nitazoxanide.

Nitazoxanide effectively treats diarrhea caused by Giardia intestinalis and Entamoeba histolytica or E. dispar, reducing morbidity and costs.

RCTHighly Cited

2001·

155citations

·J. Rossignol et al.

Sodium acetate/sodium butyrate alleviates lipopolysaccharide-induced diarrhea in mice via regulating the gut microbiota, inflammatory cytokines, antioxidant levels, and NLRP3/Caspase-1 signaling

Sodium acetate/sodium butyrate supplementation alleviates lipopolysaccharide-induced diarrhea in mice by regulating gut microbiota, inflammatory cytokines, antioxidant levels, and NLRP3/Caspase-1 signaling.

RCT

2022·

18citations

·Xiu P. Chen et al.

Use of oral sodium cromoglycate in persistent diarrhoea.

Oral sodium cromoglycate significantly improves persistent diarrhoea in some patients, suggesting food allergy as a major contributing cause.

RCT

1980·

31citations

·T. Bolin

Treatment of diarrhea caused by Cryptosporidium parvum: a prospective randomized, double-blind, placebo-controlled study of Nitazoxanide.

Nitazoxanide effectively treats diarrhea caused by Cryptosporidium parvum, reducing the duration and oocyst shedding in most patients within 3-4 days of treatment initiation.

RCTHighly Cited

2001·

353citations

·J. Rossignol et al.

Drug-Induced Diarrhoea

Drug-induced diarrhoea is a common and often severe adverse effect, with antimicrobials being responsible for 25% of cases.

Highly Cited

2000·

168citations

·O. Chassany et al.

Try another search

high dose rosuvastatin

anti anxiety meds list

buprenorphine naloxone 8mg/2mg

therapy for depression near me

adhd test for teens

minerals in food