Does metformin make you sleepy

Pro Research Analysisby

Searched over 200M research papers

Analyzed relevant papers

Does Metformin Make You Sleepy?

Metformin and Sleep Architecture in Diabetic Patients

Metformin, a widely used medication for Type II Diabetes Mellitus (DM), has been shown to influence sleep patterns in diabetic patients. A study examining 29 diabetic patients on Metformin revealed significant alterations in sleep architecture. These patients exhibited reduced restorative phases of deep sleep (N3) and REM sleep, which are crucial for feeling rested and alert during the day. The study found that all stages of sleep were reduced, with a more significant decrease in deep and REM sleep compared to normal levels . This disruption in sleep architecture could potentially contribute to feelings of fatigue and excessive daytime sleepiness in diabetic patients on Metformin.

Metformin and Sleep Disorders in Adolescent Girls with PCOS

In adolescent girls with polycystic ovarian syndrome (PCOS), Metformin has been observed to have a beneficial effect on sleep disorders. A study involving 90 adolescent girls divided into three groups (control, untreated PCOS, and PCOS treated with Metformin) found that Metformin administration significantly reduced sleep disturbances and excessive daytime sleepiness. The treated group showed improvements in body weight, body mass index, and insulin sensitivity, which are factors that can influence sleep quality . This suggests that Metformin may help alleviate sleep-related issues in this population, potentially reducing feelings of sleepiness during the day.

Metformin's Impact on Sleep and Activity Levels in Metabolic Syndrome

A year-long study on individuals with metabolic syndrome (MS) assessed the effects of Metformin on sleep and daily activity levels. Participants were randomized into Metformin and placebo groups, with sleep and activity monitored over a 7-day period. The Metformin group showed significant improvements in sleep parameters, including increased actual sleep time and sleep efficiency, compared to the placebo group. These findings indicate that Metformin may enhance sleep quality in people with MS, which could help reduce daytime sleepiness .

Conclusion

While Metformin is primarily used to manage blood glucose levels in diabetic patients, its impact on sleep is multifaceted. In diabetic patients, Metformin may disrupt sleep architecture, leading to reduced deep and REM sleep, which can contribute to daytime sleepiness . Conversely, in adolescent girls with PCOS and individuals with metabolic syndrome, Metformin has been shown to improve sleep quality and reduce sleep disturbances, potentially alleviating excessive daytime sleepiness 23. Therefore, the effect of Metformin on sleepiness may vary depending on the underlying health condition and individual patient characteristics. Further research is needed to fully understand these effects and optimize treatment strategies.

Sources and full results

Most relevant research papers on this topic

FRI636 Sleep Architecture In Diabetic Patients With Sleep Apnea On Metformin

Metformin improves long-term diabetes outcomes but alters sleep patterns, potentially worsening glycemic control over prolonged periods.

2023·

0citations

·Madhu Varma et al.

Effect of metformin on sleep disorders in adolescent girls with polycystic ovarian syndrome.

Metformin can reduce the incidence of sleep disorders and excessive daytime sleepiness in adolescent girls with polycystic ovarian syndrome.

2014·

39citations

·A. El-Sharkawy et al.

Sleep behavior and daily activity levels in people with metabolic syndrome: effect of 1 year of metformin treatment

Metformin treatment can improve sleep and daily activity levels in people with metabolic syndrome, potentially acting as an adjuvant treatment for sleep disorders.

RCT

2023·

0citations

·E. Bruno et al.

The mechanisms of action of metformin

Metformin improves glucose metabolism and diabetes-related complications through multiple mechanisms, including reducing hepatic glucose production and a key role for the gut.

Rigorous JournalHighly Cited

2017·

1571citations

·G. Rena et al.

Metformin and the gastrointestinal tract

Metformin's efficacy and side effects are linked to its passage through the gut, which increases glucose uptake, alters the microbiome, and contributes to metformin intolerance.

Rigorous JournalHighly Cited

2016·

530citations

·L. McCreight et al.

Cardioprotection by Metformin: Beneficial Effects Beyond Glucose Reduction

Metformin has cardioprotective properties beyond glucose reduction, potentially improving heart health and reducing the risk of reinfarction and all-cause mortality in patients with coronary artery disease and congestive heart failure.

Meta-AnalysisVery Rigorous Journal

2018·

65citations

·L. Varjabedian et al.

Metformin and Its Benefits for Various Diseases

Metformin offers benefits for various diseases and aging, with potential underlying mechanisms still unclear.

Highly Cited

2020·

287citations

·Ziquan Lv et al.

Clinical Pharmacokinetics of Metformin

Metformin's pharmacokinetics and clinical response are largely mediated by organic cation transporters, with minimal impact on lactic acidosis risk.

Rigorous JournalHighly Cited

2011·

1228citations

·G. Graham et al.

Metformin as Anti-Aging Therapy: Is It for Everyone?

Metformin shows potential in retarding aging and reducing aging-related diseases, but its mechanisms and side effects need further study before it becomes a mainstay anti-aging therapy.

Literature ReviewHighly Cited

2019·

161citations

·A. Soukas et al.

Role of AMP-activated protein kinase in mechanism of metformin action.

Metformin's beneficial effects on lipids and glucose metabolism are due to activation of AMP-activated protein kinase, which reduces lipogenic enzyme expression and inhibits glucose production in hepatocytes.

Non-RCTAnimal StudyHighly Cited

2001·

5315citations

·Gaochao Zhou et al.

Try another search

difference between obsessive and compulsive behavior

benefits of probiotics

sudden blood pressure spike

side effects examples

how to treat medication side effects

hemp vs cannabis