Does metoprolol cause hot flashes

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Does Metoprolol Cause Hot Flashes?

Introduction to Metoprolol and Hot Flashes

Metoprolol is a beta-blocker commonly used to treat cardiovascular conditions such as hypertension and angina. Hot flashes, on the other hand, are sudden feelings of warmth, often associated with menopause or androgen-deprivation therapy in men. Understanding whether metoprolol can cause hot flashes is crucial for patients and healthcare providers.

Central Nervous System Effects of Metoprolol

Research has shown that metoprolol has various effects on the central nervous system (CNS). A study examining the relationship between serum concentrations of metoprolol and CNS actions found that metoprolol can influence psychomotor functions, such as reaction time and flash fusion frequency . Specifically, significant decreases in flash fusion frequency were observed, indicating that metoprolol does have CNS effects. However, these effects do not intensify at higher concentrations of the drug .

Hot Flashes and Metoprolol

The available research does not directly link metoprolol to the occurrence of hot flashes. The study on metoprolol's CNS effects did not report hot flashes as a side effect . Instead, it focused on changes in psychomotor functions and the relationship between metoprolol serum levels and CNS actions.

Conclusion

Based on the current research, there is no direct evidence to suggest that metoprolol causes hot flashes. The studies available focus on its CNS effects, such as changes in flash fusion frequency, but do not mention hot flashes as a side effect. Therefore, while metoprolol does have some CNS effects, causing hot flashes does not appear to be one of them.

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Most relevant research papers on this topic

Megestrol acetate for the prevention of hot flashes.

Low-dose megestrol acetate is well-tolerated and can significantly decrease the frequency of hot flashes in both women and men, with a side effect of withdrawal menstrual bleeding in women.

RCTHighly Cited

1994·

332citations

·C. Loprinzi et al.

The relationship between serum concentrations and central nervous system actions of metoprolol.

Metoprolol's central nervous system actions occur at low serum levels, but do not intensify at high concentrations, with hydroxymetoprolol's CNS activity potentially explaining the lag in the relationship between concentration and CNS effect.

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1985·

15citations

·F. Gengo et al.

Metoprolol

Metoprolol can worsen hypertension and pulmonary oedema in patients with underlying pheochromocytoma, leading to hospitalization and ultimately, adrenalectomy.

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2020·

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Intramuscular depot medroxyprogesterone versus oral megestrol for the control of postmenopausal hot flashes in breast cancer patients: a randomized study.

Intramuscular depot medroxyprogesterone injections provide significant and long-lasting relief from postmenopausal hot flashes in breast cancer patients, offering an alternative to estrogen replacement therapy or prolonged oral megestrol administration.

RCTHighly Cited

2002·

95citations

·G. Bertelli et al.

The effects of naloxone on hot flashes and gonadotropin secretion in postmenopausal women.

Naloxone does not affect hot flash rates, LH or FSH levels, or gonadotropin secretion in postmenopausal women, suggesting low endogenous opiates contribute to hot flash initiation.

RCT

1984·

64citations

·John Defazio et al.

Phase III, placebo-controlled trial of three doses of citalopram for the treatment of hot flashes: NCCTG trial N05C9.

Citalopram effectively manages hot flashes in postmenopausal women, with broader helpful effects more evident at 20 mg/d.

RCTRigorous JournalHighly Cited

2010·

119citations

·D. Barton et al.

Pathophysiology and treatment of hot flashes.

Hot flashes are common in postmenopausal women and can be effectively managed with behavioral changes, vitamin E, estrogen replacement therapy, or newer antidepressant agents.

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2002·

281citations

·T. Shanafelt et al.

Long term use of megestrol acetate by cancer survivors for the treatment of hot flashes

Long term use of low dose megestrol acetate effectively reduces hot flashes in breast carcinoma survivors and men with prostate carcinoma after androgen deprivation therapy, but long term safety and effectiveness remain unclear.

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1998·

101citations

·Susan K. Quella et al.

Venlafaxine in management of hot flashes in women with breast cancer: a systematic review and meta-analysis

Venlafaxine effectively reduces hot flashes in women with breast cancer compared to non-hormonal treatments, but methodological issues and publication bias may limit a more comprehensive review.

Meta-AnalysisRigorous Journal

2015·

38citations

·R. Ramaswami et al.

Phase II evaluation of S-adenosyl-L-methionine (SAMe) for the treatment of hot flashes

SAMe does not significantly reduce hot flashes more than expected with a placebo, but is well-tolerated and does not negatively impact quality of life.

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2016·

4citations

·K. Kadakia et al.

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