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These studies suggest that dry cough and wheezing in children can be influenced by environmental factors, underlying conditions such as asthma or upper airway disease, and may require careful clinical evaluation to determine the correct diagnosis and treatment.
20 papers analyzed
Environmental and Socioeconomic Factors
Research conducted in Tembisa, South Africa, highlights the significant impact of environmental and socioeconomic factors on the prevalence of dry cough and wheezing in children. Children living in areas with frequent truck traffic were more likely to experience dry cough, while those whose mothers had lived in the area for longer periods were more prone to wheezing. This suggests that prolonged exposure to environmental pollutants and possibly other stressors in industrial areas can exacerbate respiratory issues in children.
Indoor Risk Factors
A study in Chile identified several indoor risk factors associated with dry cough and wheezing. Smoking, past smoking, and exposure to environmental tobacco smoke were strongly linked to both conditions. Additionally, the use of coal for heating, as well as the presence of leaks, mold, and poor kitchen ventilation, were significant contributors to respiratory morbidity. These findings underscore the importance of improving indoor air quality to reduce respiratory problems.
Phenotypic Characteristics and Comorbidities
A population-based study in Zurich, Switzerland, compared children with dry night cough, wheeze, and both symptoms. It was found that children with dry cough alone reported more frequent colds, rhinitis, and snoring, while those with wheeze or both symptoms had higher incidences of hay fever, eczema, and parental histories of asthma. Interestingly, children with dry cough had similar FeNO and spirometry results to asymptomatic children, whereas those with wheeze showed higher FeNO and evidence of bronchial obstruction. This indicates that dry cough alone may not be as strongly associated with asthma as wheezing is.
Healthcare Use and Treatment
Children with dry cough used healthcare services less frequently than those with wheeze, primarily attending primary care. Only a small subgroup (7%) of children with dry cough had characteristics typical of asthma and used inhalers, suggesting that most cases of dry cough should be investigated for other causes, particularly upper airway diseases.
Chronic Cough and Eosinophilia
A case study of a 3-year-old girl with a history of severe persistent asthma presented with chronic cough that evolved from dry to productive, accompanied by wheezing and nasal congestion. This case highlights the complexity of diagnosing and managing chronic cough in children with underlying conditions like asthma.
Dry Cough and Respiratory Distress
An 11-year-old boy with a history of asthma presented with dry cough and respiratory distress. Despite initial treatment for asthma, further investigation revealed vocal cord dysfunction and adult-onset laryngomalacia, conditions that were managed with psychiatric intervention for associated psychological disorders. This case emphasizes the need for comprehensive evaluation beyond asthma in children with persistent respiratory symptoms.
Risk of Developing Asthma
Longitudinal studies have shown that nocturnal dry cough in early childhood is a significant risk factor for developing asthma by school age. Children with nocturnal dry cough, especially when combined with wheeze, had a higher likelihood of being diagnosed with asthma later in life . This suggests that early identification and management of nocturnal dry cough could be crucial in preventing the progression to asthma.
The research collectively indicates that both environmental and indoor factors significantly contribute to the prevalence of dry cough and wheezing in children. While dry cough alone is less likely to be associated with asthma compared to wheezing, it still warrants thorough investigation to rule out other potential causes. Early identification and intervention, particularly in high-risk environments, are essential in managing and potentially preventing chronic respiratory conditions in children.
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