Gabapentin cyclobenzaprine

Pro Research Analysisby

Searched over 200M research papers for "gabapentin cyclobenzaprine"

Analyzed relevant papers

Gabapentin and Cyclobenzaprine: Efficacy and Side Effects in Topical Applications

Introduction to Gabapentin and Cyclobenzaprine

Gabapentin and cyclobenzaprine are commonly prescribed medications for managing chronic pain and muscle spasms, respectively. While traditionally administered orally, there is growing interest in their topical application to mitigate systemic side effects and reduce the risk of misuse and addiction.

Efficacy of Topical Gabapentin

Absorption and Urinary Concentrations

Research indicates that the absorption efficiency of gabapentin when applied topically is significantly lower compared to oral administration. A study analyzing over 29,000 specimens found that gabapentin concentrations in urine were often below detectable limits in patients using the drug topically, with levels in positive specimens being much lower than those in oral users (261 ng/mL vs. >10,000 ng/mL) . This suggests that while topical gabapentin may be beneficial for localized pain relief, its systemic absorption is minimal.

Efficacy of Topical Cyclobenzaprine

Absorption and Urinary Concentrations

In contrast to gabapentin, cyclobenzaprine shows a more efficient absorption profile when applied topically. The same study found that cyclobenzaprine was equally likely to be detected in urine whether administered orally or topically, although the mean levels after topical dosing were approximately 13-21% of those after oral dosing . This indicates that topical cyclobenzaprine can achieve detectable systemic levels, potentially offering effective muscle relaxation with reduced systemic exposure.

Side Effects and Allergic Reactions

Allergic Contact Dermatitis

Despite the potential benefits, topical application of these medications is not without risks. A case study reported the first instance of allergic contact dermatitis to cyclobenzaprine. A patient with degenerative disc disease developed an itchy rash after using a compounded topical cream containing cyclobenzaprine, among other ingredients. Patch testing confirmed a hypersensitivity reaction to cyclobenzaprine, highlighting the need for careful monitoring of skin reactions in patients using topical formulations .

Conclusion

Topical applications of gabapentin and cyclobenzaprine offer promising alternatives to oral administration, potentially reducing systemic side effects and the risk of misuse. However, the efficacy of topical gabapentin is limited by its poor absorption, whereas cyclobenzaprine shows more favorable absorption characteristics. Clinicians should also be aware of the potential for allergic reactions, particularly with cyclobenzaprine, and monitor patients accordingly. Further research is needed to optimize formulations and ensure the safety and efficacy of these topical treatments.

Sources and full results

Most relevant research papers on this topic

Urinary Concentrations of Topically Administered Pain Medications.

Topical pain medications like gabapentin and ketamine are more readily detectable in urine than oral medications, but cyclobenzaprine and amitriptyline levels are less likely to be detectable.

Observational Study

2016·

2citations

·Michele A Glinn et al.

Novel use of patch testing in the first report of allergic contact dermatitis to cyclobenzaprine.

Cyclobenzaprine is the cause of allergic contact dermatitis in a patient with cervical dysesthesia, suggesting it may be a potential allergen in pain medications.

Case Report

2015·

7citations

·Jake E. Turrentine et al.

Gabapentin: An Alternative to the Cyclooxygenase-2 Inhibitors for Perioperative Pain Management

Gabapentin (1.2 g/d PO) is an acceptable alternative to rofecoxib (50 mg/d PO) for short-term use as an adjuvant to opioid analgesics in patients undergoing lower abdominal surgery.

RCTHighly Cited

2006·

130citations

·Alparslan Turan et al.

Gabapentin misuse, abuse and diversion: a systematic review.

Gabapentin misuse is prevalent globally, with substance abuse populations at a higher risk for misuse/abuse, primarily for recreational purposes and self-medication.

Systematic ReviewRigorous JournalHighly Cited

2016·

282citations

·R. Smith et al.

Gabapentin as an antiepileptic drug in man.

Gabapentin shows a dose-related antiepileptic effect in patients with severe epilepsy, is well-tolerated, and shows no significant drug interactions.

Highly Cited

1987·

123citations

·P. Crawford et al.

Gabapentin for chronic neuropathic pain in adults.

Gabapentin at 1200 mg daily or greater provides moderate to substantial pain relief for adults with chronic neuropathic pain conditions like postherpetic neuralgia and painful diabetic neuropathy.

Systematic ReviewVery Rigorous JournalHighly Cited

2017·

403citations

·P. Wiffen et al.

Gabapentin

Gabapentin is an effective adjunct therapy for partial seizures in patients 12 and older with epilepsy, with a response rate of up to 28% in double-blind, placebo-controlled trials.

RCT

1999·

3citations

·G. Morris

Characterisation of [3H]gabapentin binding to a novel site in rat brain: homogenate binding studies.

A novel binding site in the brain may mediate the anticonvulsant effects of gabapentin and other potential anticonvulsant compounds.

In Vitro StudyHighly Cited

1993·

237citations

·N. Suman-Chauhan et al.

Gabapentin inhibits calcium currents in isolated rat brain neurons

Gabapentin inhibits calcium currents in rat brain neurons, suggesting it may be a direct target for treating various neurological conditions involving intracellular calcium accumulation.

In Vitro StudyHighly Cited

1998·

207citations

·A. Stefani et al.

The Novel Anticonvulsant Drug, Gabapentin (Neurontin), Binds to the Subunit of a Calcium Channel (*)

Gabapentin, a novel anticonvulsant drug, interacts with the subunit of a voltage-dependent calcium channel, potentially offering a new treatment for epilepsy.

In Vitro StudyHighly Cited

1996·

1118citations

·N. Gee et al.

Try another search

mars size compared to earth

stages of a star

medications that cause memory loss

satellite satellite satellite

expired inhaler

artificial intelligence and machine learning