Globulin normal range
Pro Research Analysisby 
Searched over 200M research papers
Normal Range of Globulin Levels in Human Serum
Gamma Globulin Normal Range
Gamma globulin, a type of immune globulin, plays a crucial role in the body's immune response. The normal concentration of gamma globulin in adult human serum ranges from 0.7 to 1.7 g/100 ml. This range was determined using the salt-fractionation method and confirmed by both biuret and tyrosine reagent methods, which showed no significant differences in results .
Immune Globulin Levels by Age
The levels of immune globulins, including gamma globulin (γG), vary significantly with age. In adults, the normal levels are approximately 1158 ± 305 mg/100 ml for γG, 99 ± 27 mg/100 ml for γM, and 200 ± 61 mg/100 ml for γA. These levels are generally reached by the age of 16 23. In newborns, the γG level in umbilical cord serum is similar to that of adults, but γM and γA levels are initially low and increase after birth 23.
Structural Relations Between Normal and Pathologic Gamma Globulins
Normal gamma globulins and their pathologic counterparts, such as myeloma globulins, share similar molecular weights and sedimentation coefficients. Both normal and pathologic gamma globulins exhibit immunologic cross-reactivity, indicating common antigenic determinants. This suggests a family of proteins with generic structural similarities, although pathologic gamma globulins may have unique properties .
Gc-Globulin in Acute Liver Failure
Gc-globulin, another type of globulin, is an actin scavenger whose levels are significantly reduced in acute liver failure (ALF). The normal range for Gc-globulin is 350-500 mg/L. In patients with ALF, lower levels of Gc-globulin are associated with poorer outcomes, including death or the need for transplantation. Specifically, a cutoff level of 80 mg/L in non-acetaminophen-induced ALF has been shown to have predictive value for patient outcomes .
Conclusion
Understanding the normal ranges and variations of different types of globulins, such as gamma globulin and Gc-globulin, is essential for diagnosing and managing various health conditions. Gamma globulin levels in adults typically range from 0.7 to 1.7 g/100 ml, while Gc-globulin levels range from 350 to 500 mg/L. These values can vary with age and in response to specific health conditions, highlighting the importance of age-matched controls and context-specific evaluations.
Sources and full results
Most relevant research papers on this topic