Headache nausea fatigue

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Understanding Headache, Nausea, and Fatigue: Insights from Recent Research

Headache, Nausea, and Fatigue in Hangovers

Loxoprofen Sodium for Hangover Symptoms

A nationwide randomized, double-blind, placebo-controlled trial evaluated the efficacy of loxoprofen sodium in alleviating fatigue, headache, and nausea after hangovers. The study found that while loxoprofen sodium significantly relieved headaches, it did not show a statistically significant effect on general fatigue or nausea compared to the placebo .

Migraine-Related Symptoms

Pathophysiology and Symptomatology of Migraine

Migraine is a prevalent neurological disorder characterized by unilateral throbbing headaches, often accompanied by nausea, multisensory hypersensitivity, and marked fatigue. These symptoms are believed to result from dysfunctional homeostatic mechanisms in the central nervous system, leading to increased susceptibility to migraine attacks .

Comparative Tolerability of Migraine Treatments

A network meta-analysis of treatments for acute migraine revealed that triptans, a common class of migraine medications, are associated with increased odds of adverse events such as somnolence, fatigue, and chest discomfort. However, non-triptan treatments like acetaminophen showed a comparable tolerability profile to placebo, indicating fewer adverse effects .

Frequency and Burden of Migraine-Associated Nausea

Nausea is a defining feature of migraines and significantly contributes to the overall burden of the condition. Population-based studies have quantified the frequency and impact of nausea in individuals with migraines, highlighting its role in exacerbating the disability associated with migraine attacks .

Headache, Nausea, and Fatigue in Other Conditions

Neurological Manifestations in COVID-19

A meta-analysis of neurological symptoms in COVID-19 patients found that headache, fatigue, and nausea are common manifestations. The pooled prevalence rates were 14.6% for headache, 33.6% for fatigue, and 9.8% for nausea, indicating a significant involvement of the nervous system in COVID-19 .

Case Studies of Headache, Nausea, and Fatigue

Several case studies have documented the occurrence of headache, nausea, and fatigue in various medical conditions. For instance, a 41-year-old woman with a sellar neoplasm experienced persistent nausea and fatigue despite some improvement in headaches post-surgery . Another case involved a 49-year-old man with chronic myeloid leukemia who presented with headache, dizziness, and nausea, alongside moderate fatigue and weight loss .

Conclusion

Headache, nausea, and fatigue are interrelated symptoms that can arise from various conditions, including hangovers, migraines, and systemic illnesses like COVID-19 and chronic myeloid leukemia. While specific treatments like loxoprofen sodium can effectively alleviate headaches, their impact on fatigue and nausea may be limited. Understanding the underlying mechanisms and comparative tolerability of treatments is crucial for managing these symptoms effectively.

Sources and full results

Most relevant research papers on this topic

A Nationwide Randomised, Double-Blind, Placebo-Controlled Physicians' Trial of Loxoprofen for the Treatment of Fatigue, Headache, and Nausea after Hangovers.

Loxoprofen sodium effectively relieves headaches after hangovers but does not significantly affect general fatigue or nausea.

RCT

2020·

6citations

·M. Hara et al.

Comparative tolerability of treatments for acute migraine: A network meta-analysis

Triptans are associated with higher odds of treatment-related adverse events compared to placebo and non-triptans, but non-triptans show comparable tolerability outcomes.

Meta-AnalysisRigorous Journal

2017·

53citations

·K. Thorlund et al.

An Update: Pathophysiology of Migraine.

Migraine likely results from dysfunctional homeostatic mechanisms, with abnormal central nervous system responses to extrinsic and intrinsic cues increasing attack susceptibility.

Highly Cited

2019·

130citations

·P. Goadsby et al.

Headache · fatigue · blurred vision · Dx?

One month after moving into her mother's apartment, a 27-year-old woman sought care at our clinic for fatigue, headache, blurred vision, nausea, and morning vomiting. She had weakness and difficulty sleeping, but denied any fever, rashes, neck stiffness, recent travel, trauma, or tobacco or illicit drug use. She did, however, have a 6-year history of migraines.

Case Report

2015·

5citations

·Barbara McMillan-Persaud et al.

Neurological Manifestations in COVID-19 Patients: A Meta-Analysis

COVID-19 patients experience various neurological manifestations related to the central and peripheral nervous systems, with high heterogeneity among studies.

Meta-Analysis

2021·

55citations

·Vitalakumar D et al.

TTF-1 Expressing Sellar Neoplasm with Ependymal Rosettes and Oncocytic Change: Mixed Ependymal and Oncocytic Variant Pituicytoma

A 1.7-cm sellar mass with suprasellar extension and contact with the optic apparatus was diagnosed in a 41-year-old woman with nausea, headaches, and fatigue.

Case Report

2014·

22citations

·Zaid Saeed Kamil et al.

Migraine

Migraine headache is a common, disabling condition with genetic factors and a complex pathophysiology, but effective treatments can prevent attacks and relieve symptoms.

Highly Cited

2007·

742citations

·J. Wilson

Blood consult: high Sokal risk chronic myeloid leukemia and suboptimal response.

ICU, and laboratory tests revealed a high Sokal risk chronic myeloid leukemia with suboptimal response, suggesting a need for aggressive treatment.

Case Report

2011·

3citations

·L. Roy et al.

"Fatigue on rest" and associated symptoms (headache, vertigo, blurred vision, nausea, tension and irritability) due to locally asymptomatic, unerupted, impacted teeth.

Locally asymptomatic, unerupted impacted teeth can cause fatigue, headaches, vertigo, and other symptoms, with removal of the impactions alleviating these symptoms.

1979·

15citations

·D. Eidelman

Frequency and Burden of Headache‐Related Nausea: Results From the American Migraine Prevalence and Prevention (AMPP) Study

While nausea is a defining feature of migraine, the association of nausea with other headache features and its influence on the burden of migraine have not been quantified. Population‐based data were used to elucidate the relative frequency and burden of migraine‐associated nausea in persons with migraine.

Observational StudyHighly Cited

2013·

70citations

·R. Lipton et al.

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