High b12 causes
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Causes of High Vitamin B12 Levels
Introduction to Hypervitaminosis B12
Hypervitaminosis B12, or elevated levels of vitamin B12 in the blood, is a condition that can arise from various underlying causes. While vitamin B12 is essential for cellular metabolism, DNA synthesis, and neurological function, excessively high levels can indicate underlying health issues or result from specific treatments.
Vitamin B12 Binding Proteins and Supplementation
One cause of high serum vitamin B12 levels is the presence of a vitamin B12 binding protein in the serum. This protein, likely an antibody, can significantly increase the serum's vitamin B12-binding capacity, leading to elevated B12 levels following treatment with vitamin B12 preparations with a retarded effect 1.
Cancer and Elevated Vitamin B12
Several studies have explored the relationship between high plasma vitamin B12 levels and cancer. Elevated B12 levels have been observed in patients with various cancers, including liver cancer. However, the association between high B12 levels and cancer is not consistent across all studies. Some research suggests that genetically determined high plasma B12 may be linked to cancer, but there is insufficient evidence to establish a causal relationship between high B12 intake or treatment and cancer development 25.
Hematological and Hepatic Disorders
High serum B12 levels are often associated with hematological and hepatic disorders. Conditions such as solid neoplasia (both primary and metastatic), acute or chronic hematological diseases, liver disorders, and monoclonal gammopathy of undetermined significance can lead to elevated B12 levels. Renal failure, inflammatory or autoimmune diseases, and transient hematological disorders like neutrophilia and secondary eosinophilia are also potential causes 36.
Mortality Risks in Hypertensive Populations
In hypertensive populations, high serum B12 levels have been linked to increased risks of all-cause and cardiovascular mortality. This association appears to be independent of other factors such as baseline folate and plasma total homocysteine levels. These findings suggest that elevated B12 levels could be a marker for increased mortality risk in these individuals 4.
Conclusion
High vitamin B12 levels can result from various factors, including the presence of specific binding proteins, underlying cancers, hematological and hepatic disorders, and increased mortality risks in certain populations. While elevated B12 levels can indicate serious health issues, the exact mechanisms and causal relationships require further investigation. Understanding these associations is crucial for improving diagnostic and therapeutic strategies related to vitamin B12 metabolism.
Sources and full results
Most relevant research papers on this topic
A new vitamin B12 binding protein in serum causing excessively high serum vitamin B12 values.
A new vitamin B12 binding protein in the G area can cause extremely high serum vitamin B12 values, potentially due to an antibody.
High Plasma Vitamin B12 and Cancer in Human Studies: A Scoping Review to Judge Causality and Alternative Explanations
High plasma vitamin B12 levels and cancer are not consistently associated, and low vitamin B12 status in cancer patients needs to be diagnosed and treated to prevent hematological and neurological sequelae.
Systematic Review
Very Rigorous Journal[Hypervitaminosis B12. Our experience and a review].
High serum levels of vitamin B12 can be caused by various diseases, including solid neoplasia, hematological diseases, liver disorders, and excess vitamin B12 intake.
Rigorous JournalAbstract 12719: The Association of High Vitamin B12 With Mortality Risks and Related Metabolisms Among Hypertensive Population
Elevated B12 levels are associated with increased risk of all-cause mortality in Chinese adults with hypertension, independent of baseline folate, tHcy, and other traditional risk factors.
Vitamin B12 deficiency - A 21st century perspective .
Vitamin B12 deficiency is a common condition with potential severe complications, and early diagnosis and management are crucial to prevent complications.
Highly CitedIf high folic acid aggravates vitamin B12 deficiency what should be done about it?
High folic acid intake during vitamin B12 deficiency can exacerbate anemia and worsen cognitive symptoms, suggesting public health strategies to improve vitamin B12 status are needed.
Vitamin B12 deficiency
Vitamin B12 deficiency affects individuals of all ages, particularly the elderly, and is caused by inadequate intake, bioavailability, or malabsorption, with management relying on B12 supplementation.
Highly CitedVitamin B12 deficiency induces glucose intolerance, delays peak insulin levels and promotes ketogenesis in female rats.
B12 deficiency in female rats leads to glucose intolerance, delayed peak insulin levels, and increased ketogenesis, potentially promoting the development of metabolic disorders like diabetes mellitus.
RCT
Animal StudyRigorous JournalVitamin B12 in Relation to Oxidative Stress: A Systematic Review
Lower B12 status may be linked to increased oxidative stress, but more research is needed to confirm this relationship.
Systematic ReviewVery Rigorous JournalHighly Cited