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These studies suggest that a low sodium diet, especially when combined with the DASH diet, effectively lowers blood pressure in both hypertensive and normotensive individuals.
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High blood pressure, or hypertension, is a significant public health concern. One of the dietary strategies to manage hypertension is reducing sodium intake. This article synthesizes research findings on the effects of a low sodium diet on blood pressure, highlighting the benefits and potential side effects.
Multiple studies have demonstrated that reducing sodium intake can significantly lower blood pressure in both hypertensive and normotensive individuals. For instance, reducing sodium intake from high to intermediate levels decreased systolic blood pressure (SBP) by 2.1 mm Hg and from intermediate to low levels by an additional 4.6 mm Hg in a control diet . Similarly, a systematic review found that sodium reduction led to a decrease in SBP by 1.14 mm Hg in normotensive white participants and by 5.71 mm Hg in hypertensive white participants .
In hypertensive patients, the effects are more pronounced. The DASH-Sodium trial showed that a combination of the DASH diet and low sodium intake resulted in a mean SBP reduction of 11.5 mm Hg in hypertensive participants . Another study confirmed that a low sodium diet significantly reduced SBP by 3.79 mm Hg and diastolic blood pressure (DBP) by 1.62 mm Hg in diabetic patients.
The impact of sodium reduction on blood pressure also varies by race. For example, in black participants, sodium reduction resulted in a SBP decrease of 4.02 mm Hg in normotensives and 6.64 mm Hg in hypertensives . Asian participants also showed significant reductions, with hypertensive individuals experiencing a SBP decrease of 7.75 mm Hg .
While reducing sodium intake lowers blood pressure, it also affects other physiological parameters. Studies have shown that low sodium intake increases levels of renin, aldosterone, noradrenaline, and adrenaline, which are hormones involved in blood pressure regulation . Additionally, low sodium intake has been associated with increases in cholesterol and triglyceride levels .
Contrary to expectations, a low sodium DASH diet did not improve biomarkers of inflammation such as C-reactive protein (CRP) and soluble urokinase plasminogen activator receptor (suPAR). Instead, it increased levels of phosphorus and fibroblast growth factor-23 (FGF23), which are markers of mineral metabolism.
Adherence to a low sodium diet can be challenging. A pilot study tested a personalized low sodium diet (P-LSD) intervention enhanced by mobile health technology. The study found significant reductions in dietary sodium intake, SBP, and DBP in the intervention group compared to the control group, suggesting that personalized approaches may improve adherence and effectiveness.
Reducing sodium intake is an effective strategy for lowering blood pressure, particularly in hypertensive individuals. However, it is important to consider the potential hormonal and lipid changes associated with low sodium diets. Personalized dietary interventions and the DASH diet can enhance the effectiveness of sodium reduction in managing high blood pressure. Further research is needed to explore the long-term health effects and optimize dietary recommendations.
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