How long does vitamin d last in the body

Pro Research Analysisby

Searched over 200M research papers

Analyzed relevant papers

Longevity of Vitamin D in the Human Body

Biological Half-life of Vitamin D

The biological half-life of vitamin D in human plasma has been a subject of extensive research. Initial estimates suggested that the half-life of vitamin D does not exceed 50 hours based on observations of radio-isotopically labeled cholecalciferol over a period of up to 4 days . However, other studies have shown that after administering large amounts of vitamin D, the "vitamin D activity" in plasma decreases slowly, with a half-life that may exceed 3 months .

Vitamin D Storage in Body Tissues

Vitamin D is stored in various body tissues, with adipose tissue being the primary storage site. Studies on rats have shown that after vitamin D supplementation, adipose tissue contains the highest quantity of vitamin D, which remains detectable for up to 3 months . This indicates that adipose tissue serves as a significant reservoir for vitamin D, storing it in its unaltered form as well as in the form of polar metabolites and esters .

Longevity After Supplementation

The longevity of vitamin D in the body after supplementation has been demonstrated in human studies. For instance, a study involving postmenopausal women who took daily vitamin D3 supplements showed that the benefits of supplementation persisted for up to 2 years after cessation. The proportion of women with sufficient vitamin D levels remained higher in those who had taken supplements compared to those who had not . This suggests that vitamin D can have long-lasting effects even after supplementation stops.

Factors Influencing Vitamin D Longevity

Several factors can influence the longevity of vitamin D in the body. Vitamin D-binding protein (VDBP) has been identified as a predictor of circulating 25-hydroxyvitamin D (25OHD) longevity. Higher levels of VDBP are associated with prolonged presence of vitamin D in the bloodstream . Additionally, the storage of vitamin D in adipose tissue plays a crucial role in its sustained availability .

Conclusion

Vitamin D can last in the body for a considerable duration, with its half-life in plasma potentially exceeding 3 months. Adipose tissue serves as a major storage site, ensuring a steady release of vitamin D over time. Supplementation benefits can persist for years, influenced by factors such as VDBP levels and tissue storage. Understanding these dynamics is essential for optimizing vitamin D supplementation strategies and ensuring long-term health benefits.

Sources and full results

Most relevant research papers on this topic

Long Biological Half-life of Vitamin D3 and its Polar Metabolites in Human Serum

Vitamin D3 and its polar metabolites have a long biological half-life in human serum, with a half-time of up to 3 months after administration.

1969·

55citations

·E. Mawer et al.

Longevity of daily oral vitamin D3 supplementation: differences in 25OHD and 24,25(OH)2D observed 2 years after cessation of a 1-year randomised controlled trial (VICtORy RECALL)

Daily vitamin D3 supplementation shows benefits over placebo 2 years after discontinuing treatment, with vitamin D-binding protein being a predictor of vitamin D longevity.

RCTRigorous Journal

2017·

5citations

·H. Macdonald et al.

METABOLISM AND MODE OF ACTION OF VITAMIN D II. STORAGE OF VITAMIN D IN DIFFERENT TISSUES IN VIVO

Vitamin D can be stored in various tissues for up to 3 months after oral administration, providing insight into its metabolism and mode of action.

1937·

28citations

·W. Heymann

Effects of vitamin D supplementation in infancy on growth, bone parameters, body composition and gross motor development at age 3-6 years: follow-up of a randomized controlled trial.

Vitamin D supplementation in infancy led to thinner children at age 3-6 years but no significant differences in functional outcomes.

RCTLarge Human TrialRigorous Journal

2015·

48citations

·Geeta Trilok-Kumar et al.

A 12-week double-blind randomized clinical trial of vitamin D3 supplementation on body fat mass in healthy overweight and obese women

Vitamin D3 supplementation significantly reduced body fat mass in healthy overweight and obese women by increasing 25(OH) D concentrations.

RCTVery Rigorous JournalHighly Cited

2012·

178citations

·A. Salehpour et al.

Vitamin D Supplementation Improves Cognitive Function Through Reducing Oxidative Stress Regulated by Telomere Length in Older Adults with Mild Cognitive Impairment: A 12-Month Randomized Controlled Trial.

Vitamin D supplementation for 12 months improves cognitive function in older adults with mild cognitive impairment by reducing oxidative stress regulated by telomere length.

RCTRigorous Journal

2020·

60citations

·Tong Yang et al.

Deposition in and release of vitamin D3 from body fat: evidence for a storage site in the rat.

Adipose tissue is the major storage site for vitamin D3 in rats, with unaltered vitamin D3 being the principal storage form and available for conversion to other metabolites during deprivation.

Non-RCTAnimal StudyHighly Cited

1971·

264citations

·S. J. Rosenstreich et al.

Vitamin D3 increases in abdominal subcutaneous fat tissue after supplementation with vitamin D3.

Long-term supplementation with high dose vitamin D3 increases vitamin D3 storage in abdominal subcutaneous fat tissue.

RCTRigorous Journal

2015·

65citations

·A. Didriksen et al.

Vitamin D Deficiency in Adults with Musculoskeletal Pain

Vitamin D deficiency is common in adults with musculoskeletal pain, and addressing this issue through increased sun exposure and vitamin D supplements may help reduce pain and improve overall health.

2015·

5citations

·S. Atalay et al.

Effects of six months of vitamin D supplementation in patients with heart failure: a randomized double-blind controlled trial.

Six months of vitamin D supplementation significantly improves ejection fraction in elderly patients with heart failure and vitamin D deficiency.

RCTHighly Cited

2014·

94citations

·A. Dalbeni et al.

Try another search

what is psychosis like

opium medication

foods high in b12

does ibuprofen make you constipated

adverse affects

is not crying a sign of depression