How long does vitamin d stay in your system

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Duration of Vitamin D in the Human System

Biological Half-life of Vitamin D3

The biological half-life of vitamin D3 in human serum has been a subject of extensive research. Initial estimates based on radio-isotopically labelled cholecalciferol suggested that vitamin D3 has a relatively short half-life in human plasma, not exceeding 50 hours . However, other studies have shown that after the administration of large amounts of vitamin D, the "vitamin D activity" in plasma decreases much more slowly, with a half-life that can exceed three months . This indicates that while the initial breakdown of vitamin D3 might be rapid, its metabolites and overall activity can persist in the body for a significantly longer period.

Longevity of Vitamin D3 After Supplementation

Research has also focused on the longevity of vitamin D3 in the system following supplementation. A study involving postmenopausal women who had taken daily vitamin D3 supplements for one year found that the effects of supplementation could last for years after cessation. Specifically, the proportion of women with sufficient levels of 25-hydroxyvitamin D (25OHD) remained higher in those who had taken vitamin D3 compared to those who had taken a placebo, even two years after stopping the supplements . This suggests that vitamin D3 can have a prolonged presence and effect in the body, maintaining higher levels of 25OHD for an extended period post-supplementation.

Factors Influencing Vitamin D Longevity

The study also identified that the longevity of vitamin D3 in the system could be influenced by the levels of vitamin D-binding protein (VDBP). Higher levels of VDBP were associated with longer-lasting circulating 25OHD levels . This indicates that individual variations in VDBP could affect how long vitamin D3 remains effective in the body.

Conclusion

In summary, while the initial half-life of vitamin D3 in plasma may be relatively short, its metabolites and overall activity can persist for much longer, potentially exceeding three months. Furthermore, the effects of vitamin D3 supplementation can last for years, with factors such as VDBP levels influencing its longevity. This extended presence underscores the importance of considering both immediate and long-term effects when evaluating vitamin D3 supplementation and its benefits.

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Most relevant research papers on this topic

Long Biological Half-life of Vitamin D3 and its Polar Metabolites in Human Serum

Vitamin D3 and its polar metabolites have a long biological half-life in human serum, with a half-time of up to 3 months after administration.

1969·

54citations

·E. Mawer et al.

Longevity of daily oral vitamin D3 supplementation: differences in 25OHD and 24,25(OH)2D observed 2 years after cessation of a 1-year randomised controlled trial (VICtORy RECALL)

Daily vitamin D3 supplementation shows benefits over placebo 2 years after discontinuing treatment, with vitamin D-binding protein being a predictor of vitamin D longevity.

RCTRigorous Journal

2017·

4citations

·H. Macdonald et al.

Bioavailability of vitamin D(2) and D(3) in healthy volunteers, a randomized placebo-controlled trial.

Vitamin D3 increases total 25(OH)D concentration more than vitamin D2, while vitamin D2 supplementation leads to a decrease in 25(OH)D3, explaining the different effect on total 25(OH)D.

RCTRigorous JournalHighly Cited

2013·

107citations

·Ulrike Lehmann et al.

Seven Weeks of High-Dose Vitamin D Treatment Reduces the Need for Infliximab Dose-Escalation and Decreases Inflammatory Markers in Crohn’s Disease during One-Year Follow-Up

High-dose vitamin D treatment for seven weeks reduces the need for infliximab dose-escalation and decreases inflammatory markers in Crohn's disease patients during one-year follow-up.

RCTVery Rigorous Journal

2021·

12citations

·Mia Bendix et al.

The half-life of 25(OH)D after UVB exposure depends on gender and vitamin D receptor polymorphism but mainly on the start level

The half-life of 25(OH)D after UVB exposure varies based on gender, vitamin D receptor polymorphism, and start level, with higher start levels leading to a larger elimination of 25(OH)D.

Observational Study

2017·

35citations

·Pameli Datta et al.

Vitamin D Supplementation Improves Cognitive Function Through Reducing Oxidative Stress Regulated by Telomere Length in Older Adults with Mild Cognitive Impairment: A 12-Month Randomized Controlled Trial.

Vitamin D supplementation for 12 months improves cognitive function in older adults with mild cognitive impairment by reducing oxidative stress regulated by telomere length.

RCTRigorous Journal

2020·

47citations

·Tong Yang et al.

Adverse events from large dose vitamin D supplementation taken for one year or longer

Long-term high-dose vitamin D supplementation did not significantly increase the risk of total adverse events or kidney stones, but there was a trend towards increased hypercalcemia and possibly hypercalciuria.

Systematic Review

2019·

41citations

·Z. Malihi et al.

Monthly Increase in Vitamin D Levels upon Supplementation with 2000 IU/Day in Healthy Volunteers: Result from “Integriamoci”, a Pilot Pharmacokinetic Study

Vitamin D levels can increase rapidly after daily supplementation with 2000 IU/day, reducing deficiency in 62% of healthy volunteers after 28 days.

Non-RCT

2022·

2citations

·V. Avataneo et al.

Effects of six months of vitamin D supplementation in patients with heart failure: a randomized double-blind controlled trial.

Six months of vitamin D supplementation significantly improves ejection fraction in elderly patients with heart failure and vitamin D deficiency.

RCTHighly Cited

2014·

86citations

·A. Dalbeni et al.

Deposition in and release of vitamin D3 from body fat: evidence for a storage site in the rat.

Adipose tissue is the major storage site for vitamin D3 in rats, with unaltered vitamin D3 being the principal storage form and available for conversion to other metabolites during deprivation.

Non-RCTAnimal StudyHighly Cited

1971·

259citations

·S. J. Rosenstreich et al.

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