Hpv causes cancer
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Summary
10 papers analyzed
These studies suggest that HPV causes a significant proportion of cancers worldwide, particularly cervical, head and neck, and anogenital cancers, and that vaccination and other preventative strategies are crucial for reducing this burden.
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The Role of HPV in Causing Cancer
HPV and Cervical Cancer
Human papillomavirus (HPV) is a significant cause of various cancers, with cervical cancer being the most prominent. Nearly all cases of cervical cancer are attributable to HPV infection, particularly high-risk types such as HPV16 and HPV18 . These high-risk HPV types lead to the degradation of tumor suppressor proteins, such as p53 and pRb, which disrupts normal cell cycle control and promotes carcinogenesis.
HPV and Other Anogenital Cancers
In addition to cervical cancer, HPV is responsible for a substantial fraction of other anogenital cancers, including cancers of the vulva, vagina, penis, and anus. These cancers are also primarily caused by high-risk HPV types . For instance, HPV16 and HPV18 account for a significant proportion of these cancers, with HPV16 being particularly prevalent .
HPV and Oropharyngeal Cancers
HPV is increasingly recognized as a causative agent in head and neck cancers, especially oropharyngeal cancers. These cancers have distinct epidemiological and molecular characteristics compared to HPV-negative head and neck cancers . The presence of HPV in these cancers is associated with better prognosis and response to treatment compared to HPV-negative cases.
Global Burden of HPV-Related Cancers
Globally, HPV is responsible for approximately 4.5% of all cancers, with a higher burden in women (8.6%) compared to men (0.8%). Cervical cancer accounts for the majority of HPV-attributable cancers, particularly in less developed countries where screening and vaccination programs are less prevalent . Other HPV-related cancers, such as those of the vulva, vagina, penis, anus, and oropharynx, also contribute significantly to the global cancer burden .
Prevention and Vaccination
HPV vaccination is a critical strategy for preventing HPV-related cancers. The 9-valent HPV vaccine (9vHPV) protects against multiple high-risk HPV types, including HPV16, 18, 31, 33, 45, 52, and 58, as well as non-oncogenic types 6 and 11 that cause genital warts. Universal access to vaccination, particularly in less developed countries, is essential to reduce the incidence of HPV-related cancers .
Conclusion
HPV is a major cause of several cancers, with cervical cancer being the most significant. The virus also contributes to other anogenital and oropharyngeal cancers. Preventative measures, particularly vaccination, are crucial in reducing the global burden of HPV-related cancers. Continued efforts in vaccination and screening programs are necessary to mitigate the impact of this virus on public health.
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