Hydrodiuril uses

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Uses of Hydrodiuril (Hydrochlorothiazide)

Introduction to Hydrodiuril

Hydrodiuril, known chemically as hydrochlorothiazide, is a widely used oral diuretic and antihypertensive agent. It is primarily prescribed to manage conditions related to fluid retention and high blood pressure.

Treatment of Hypertension

One of the primary uses of Hydrodiuril is in the treatment of hypertension (high blood pressure). By promoting the excretion of sodium and water through the kidneys, Hydrodiuril helps to reduce blood volume, thereby lowering blood pressure. This mechanism makes it an effective first-line treatment for patients with hypertension.

Management of Edema

Hydrodiuril is also commonly used to manage edema, which is the swelling caused by excess fluid trapped in the body's tissues. This condition can occur in various parts of the body, including the lower extremities, as seen in a case study involving a pregnant woman who experienced leg swelling. The administration of Hydrodiuril helped alleviate the edema by increasing urine output and reducing fluid retention .

Prevention of Kidney Stones

Another important use of Hydrodiuril is in the prevention of kidney stones. By reducing the amount of calcium in the urine, Hydrodiuril can help prevent the formation of calcium-containing kidney stones. This makes it a valuable option for patients who are prone to recurrent kidney stones.

Side Effects and Considerations

While Hydrodiuril is effective in treating various conditions, it is not without side effects. One reported case involved transient myopia (temporary nearsightedness) and perimacular edema (swelling around the macula in the eye) in a patient taking Hydrodiuril . This highlights the importance of monitoring patients for potential adverse effects, especially when initiating therapy.

Conclusion

Hydrodiuril (hydrochlorothiazide) is a versatile medication used primarily for the treatment of hypertension and edema. It also plays a role in preventing kidney stones. However, like all medications, it is important to be aware of potential side effects and to use it under the guidance of a healthcare professional.

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Most relevant research papers on this topic

Transient myopia and retinal edema during hydrochlorothiazide (hydrodiuril) therapy.

This is a report of a case of transient myopia associated with perimacular edema apparently secondary to the use of a total of 100 mg. of hydrochlorothiazide (Hydrodiuril). Hydrochlorothiazide is an oral, nonmercurial d i u r e t i c-antihypertensive agent. It is defined chemically as 6-chloro-7-sulfamyl-3,4-dihydro-1,2,4- benzothiadiazine-1,1-dioxide. Report of Case A 21-year-old white primiparous woman whose estimated date of confinement was July 24, 1959, and whose past medical history and systemic review were noncontributory, was seen by her obstetrician on July 7, 1959, for a routine examination. Physical Examination. —Her temperature was 98F, weight 138 lb. (125 lb. before pregnancy), and blood pressure 100/70. There was some swelling of the lower extremities. Laboratory Data. —The urine revealed no albumin or sugar. Her previously determined serology was negative and blood type O Rh positive. Because of the swelling of her legs, she was advised to restrict

Case Report

1961·

25citations

·F. J. Beasley

Archives of ophthalmology

Effect of fasudil hydrochloride, a protein kinase inhibitor, on cerebral vasospasm and delayed cerebral ischemic symptoms after aneurysmal subarachnoid hemorrhage.

Fasudil hydrochloride is a safe and efficient agent for suppressing cerebral vasospasm after subarachnoid hemorrhage surgery for ruptured cerebral aneurysm, with better motor disturbance improvement than nimodipine.

RCTHighly Cited

2006·

104citations

·Ji-zong Zhaoet al.

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The Rho-Associated Kinase Inhibitor Fasudil Hydrochloride Enhances Neural Regeneration after Axotomy in the Peripheral Nervous System

Fasudil hydrochloride accelerates functional regeneration in peripheral nerves after axotomy, potentially benefiting human patients.

RCTAnimal Study

2007·

22citations

·T. Maduraet al.

Plastic and Reconstructive Surgery

Protein kinase inhibition by fasudil hydrochloride promotes neurological recovery after spinal cord injury in rats.

Fasudil hydrochloride shows promise in promoting neurological recovery after spinal cord injury in rats, potentially through protein kinase inhibition and decreased neutrophil infiltration.

RCTAnimal StudyHighly Cited

2000·

98citations

·Masahito Haraet al.

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Pharmacological profile of hydroxy fasudil as a selective rho kinase inhibitor on ischemic brain damage.

Hydroxy fasudil improves hemodynamic function and inhibits neutrophil-mediated damage, contributing to the potency and long duration of fasudil's cytoprotective properties against ischemic brain damage.

Non-RCTAnimal StudyHighly Cited

2001·

166citations

·S. Satohet al.

Life sciences

Ultra-performance hydrophilic interaction liquid chromatography coupled with tandem mass spectrometry for simultaneous determination of allopurinol, oxypurinol and lesinurad in rat plasma: Application to pharmacokinetic study in rats

The developed ultra-performance hydrophilic interaction liquid chromatography coupled with tandem mass spectrometry method effectively determines allopurinol, oxypurinol, and lesinurad in rat plasma, aiding in oral pharmacokinetic studies.

Rigorous Journal

2019·

16citations

·M. Iqbalet al.

PLoS ONE

Acute immune intravascular hemolysis due to hydrochlorothiazide.

Hydrochlorothiazide-induced hemolysis and renal failure may be caused by immune complex mechanisms, rather than methyldopa-induced hemolytic anemia.

Case Report

1981·

19citations

·G. Garrattyet al.

American journal of clinical pathology

Cucurbituril-based nanoparticles: a new efficient vehicle for targeted intracellular delivery of hydrophobic drugs.

Cucurbituril-based nanoparticles offer efficient targeted intracellular delivery of hydrophobic drugs, with high drug loading capacity and efficient cancer cell targeting.

Highly Cited

2009·

103citations

·K. Parket al.

Chemical communications

Botany, traditional uses, phytochemistry, analytical methods, processing, pharmacology and pharmacokinetics of Bupleuri Radix: A systematic review.

Bupleuri Radix (BR) has potential therapeutic benefits, but its mechanism and quality evaluation need further study for full potential.

Systematic ReviewRigorous JournalHighly Cited

2020·

71citations

·Hai Jianget al.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Enhanced liver-targeting via coadministration of 10-Hydroxycamptothecin polymeric micelles with vinegar baked Radix Bupleuri.

Vinegar baked Radix Bupleuri (VBRB) effectively enhances the liver-targeting efficiency of 10-Hydroxycamptothecin loaded polymeric micelles when coadministered orally.

In Vitro StudyRigorous Journal

2018·

17citations

·Haiyang Wuet al.

Phytomedicine : international journal of phytotherapy and phytopharmacology

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