Ibuprofen addiction

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Ibuprofen Addiction: Insights from Recent Research

Introduction to Ibuprofen and Dependence

Ibuprofen is a widely used nonsteroidal anti-inflammatory drug (NSAID) known for its effectiveness in reducing pain and inflammation. Despite its widespread use, ibuprofen has not traditionally been associated with dependence or addiction. However, recent case reports and studies suggest that there may be more to understand about its potential for dependence.

Case Report on Ibuprofen Dependence

A notable case report highlights the potential for ibuprofen dependence. In this report, a 17-year-old patient exhibited several psychological symptoms indicative of pharmacological dependence on ibuprofen. The patient self-adjusted her dosage to manage withdrawal symptoms, suggesting a physical and psychological reliance on the drug. The report hypothesizes that the effects of ibuprofen on cyclooxygenase enzymes (COX-1 and COX-2), fatty acid amide hydrolase (FAAH), and peroxisome proliferator-activated receptors (PPARs) may contribute to this dependence .

Comparison of Ibuprofen and Celecoxib in Opiate Detoxification

A study comparing the effects of ibuprofen and celecoxib in patients undergoing opiate detoxification provides further insights into ibuprofen's role in addiction contexts. The study involved 32 patients who were randomized to receive either celecoxib or ibuprofen to manage pain associated with opiate withdrawal. Both drugs were effective in reducing pain symptoms. However, a significant difference was observed in their impact on opiate craving. Celecoxib significantly reduced the craving for opiates, while ibuprofen did not show a similar effect .

Conclusion

While ibuprofen is not commonly associated with addiction, emerging evidence suggests that it can lead to dependence in certain cases. The case report of a young patient developing psychological and physical dependence on ibuprofen underscores the need for further research into its addictive potential. Additionally, the comparative study on opiate detoxification highlights that while ibuprofen is effective for pain management, it may not be as effective as celecoxib in reducing drug cravings. These findings suggest that healthcare providers should be cautious when prescribing ibuprofen, particularly for long-term use, and consider the potential for dependence in their patients.

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Most relevant research papers on this topic

Ibuprofen Dependence: A Case Report

Ibuprofen dependence can develop in young patients, with positive psychological symptoms and withdrawal symptoms, indicating pharmacological effects on COX-1, COX-2, FAAH, and PPARs.

Case Report

2014·

10citations

·F. Etcheverrigaray et al.

Craving and Drug Reward: A Comparison of Celecoxib and Ibuprofen in Detoxifying Opiate Addicts

Celecoxib significantly reduces opiate cravings in patients undergoing detoxification, while ibuprofen equally reduces pain symptoms.

RCTRigorous Journal

2017·

5citations

·S. Jafari et al.

Toxic, Genotoxic and Teratogenic Effects of Ibuprofen and its Derivatives.

Ibuprofen is a toxic, genotoxic, and teratogenic agent in various organisms, with potential carcinogenic potential.

Systematic Review

2023·

4citations

·Dilan Calisici et al.

Single dose oral ibuprofen for acute postoperative pain in adults.

Ibuprofen is an effective analgesic for treating postoperative pain, with high-quality evidence supporting its use at 200 mg and 400 mg doses.

Systematic ReviewVery Rigorous JournalHighly Cited

2009·

149citations

·C. Derry et al.

Use of ibuprofen and risk of Parkinson disease

Ibuprofen use is associated with a lower Parkinson's disease risk, suggesting it should be further investigated as a potential neuroprotective agent against the disease.

Meta-AnalysisHighly Cited

2011·

290citations

·Xiang Gao et al.

Ibuprofen Safety at the Golden Anniversary: Are all NSAIDs the Same? A Narrative Review

Ibuprofen has a favorable safety profile and is effective for many pain conditions, but like other NSAIDs, it carries risks and may be an endocrine disrupter.

Literature ReviewHighly Cited

2019·

110citations

·G. Varrassi et al.

Single-dose intravenous ibuprofen for acute postoperative pain in adults.

Single-dose intravenous ibuprofen is effective for moderate-to-severe postoperative pain in adults, with a risk ratio of 1.44 (95% CI 0.77 to 2.66 versus placebo) compared to 22% for placebo.

Meta-AnalysisVery Rigorous Journal

2019·

12citations

·McKenzie C. Ferguson et al.

Ibuprofen hepatic encephalopathy, hepatomegaly, gastric lesion and gastric pentadecapeptide BPC 157 in rats.

BPC 157 effectively counteracts the adverse effects of chronic ibuprofen in rats, maintaining normal weight gain and no behavioral disturbances.

Non-RCTAnimal StudyRigorous Journal

2011·

58citations

·Spomenko Ilić et al.

Intravenous Ibuprofen

Intravenous ibuprofen reduces morphine consumption and provides better pain relief than placebo, with the most common adverse event being pruritus.

RCTLarge Human Trial

2012·

27citations

·L. Scott

Renal effects of ibuprofen, piroxicam, and sulindac in patients with asymptomatic renal failure. A prospective, randomized, crossover comparison.

A brief course of ibuprofen may cause acute renal failure in patients with asymptomatic, mild chronic renal failure.

RCTHighly Cited

1990·

194citations

·A. Whelton et al.

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