Is hemp oil safe
Pro Research Analysisby 
Searched over 200M research papers
Safety of Hemp Oil: A Comprehensive Review
Toxicological Safety of Hemp Oil
VOHO Hemp Oil Safety Studies
VOHO Hemp Oil, derived from the aerial parts of hemp using supercritical CO2 extraction, has undergone extensive safety testing. Four key studies were conducted: a bacterial reverse mutation assay, an in vivo mammalian micronucleus study, a maximum tolerated dose study in rats, and a 90-day repeat dose subchronic toxicity study in rats. The results indicated that VOHO Hemp Oil is non-mutagenic and does not induce micronuclei in rat bone marrow. The maximum tolerated dose was found to be 2250 mg/kg bw/day, and the no observed adverse effect level (NOAEL) was determined to be 90 mg/kg bw/day in both male and female Wistar rats.
Clinical Safety in Human Subjects
A study on the effects of a commercially available CBD-containing hemp oil extract on overweight but otherwise healthy subjects found that the hemp oil was well tolerated. The study reported improvements in HDL cholesterol and tendencies towards better stress resilience and sleep quality. Importantly, all clinical safety markers, including hepato-renal function and cardiovascular health, remained within normal limits, indicating no significant safety concerns.
Cannabidiol (CBD) and Hemp Oil: Clinical Insights
Overview and Legal Status
CBD oils, including hemp oil, have gained popularity for their potential therapeutic benefits, particularly in pain management and epilepsy treatment. The first CBD-based drug, Epidiolex, was approved by the FDA in 2018 for severe epilepsy. However, the lack of regulation and potential for inaccurate labeling of CBD and THC quantities necessitates caution when recommending these products. Clinicians are advised to guide patients towards high-quality, evidence-based formulations.
Therapeutic Applications and Cytotoxicological Profiles
Encapsulation and Cytotoxicity
Hemp essential oils (EOs) and their nanoemulsions (NEs) have been evaluated for their cytotoxicological profiles. Studies on cell lines relevant to topical and inhalant administration showed that both EOs and NEs have comparable cytotoxicity. Additionally, these formulations did not alter the basal level of inflammatory cytokines, suggesting a favorable safety profile for potential therapeutic applications.
Anti-Inflammatory and Mosquitocidal Properties
Hemp EOs have demonstrated promising anti-inflammatory and mosquitocidal properties. The EOs from different hemp varieties were found to be effective against mosquito larvae and pupae, with low LC50 values. Furthermore, these EOs exhibited no cytotoxicity at appropriate doses and had an anti-inflammatory effect on human cell lines, supporting their safe use in various applications.
Conclusion
The body of research indicates that hemp oil, particularly CBD-containing formulations, is generally safe for use, with no significant adverse effects reported in both animal and human studies. However, due to the variability in product quality and labeling, it is crucial to select high-quality, well-regulated products. The therapeutic potential of hemp oil, including its anti-inflammatory and mosquitocidal properties, further underscores its versatility and safety for various applications.
Sources and full results
Most relevant research papers on this topic