Is lyrica a controlled substance

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Is Lyrica a Controlled Substance?

Introduction to Lyrica (Pregabalin)

Lyrica, known generically as pregabalin, is a medication primarily used to treat conditions such as epilepsy, generalized anxiety disorder, neuropathic pain, and fibromyalgia. It functions as an analog of the gamma-aminobutyric acid (GABA) neurotransmitter, which plays a crucial role in regulating neuronal excitability throughout the nervous system .

Controlled Substance Status of Lyrica

Regulatory Classification

Pregabalin is classified as a controlled substance in many countries due to its potential for abuse and dependence. For instance, in Saudi Arabia, pregabalin is regulated under controlled substance laws to mitigate the risks associated with its misuse . This classification is a response to the increasing instances of unofficial and non-prescribed use of the drug, which can lead to significant health risks.

Abuse and Dependence Potential

The potential for pregabalin abuse has been documented in various studies. Chronic abuse of pregabalin can lead to neurotoxic effects, including dysregulation in neurotransmitter release, increased oxidative stress, and brain tissue inflammation. These effects are dose-dependent, with higher doses leading to more severe neurotoxic outcomes . This evidence underscores the necessity of controlling the distribution and use of pregabalin to prevent its misuse and the associated health risks.

Conclusion

Lyrica (pregabalin) is indeed a controlled substance in many regions due to its potential for abuse and dependence. Regulatory measures are in place to control its distribution and use, aiming to prevent the adverse effects associated with its misuse. The classification of pregabalin as a controlled substance is supported by evidence of its neurotoxic effects when abused, highlighting the importance of adhering to prescribed dosages and medical guidance.

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Most relevant research papers on this topic

A pilot, double‐blind, placebo‐controlled trial of pregabalin (Lyrica) in the treatment of essential tremor

Pregabalin (Lyrica) significantly reduced tremor amplitude and improved action tremor limb scores in essential tremor patients, but larger studies are needed for further evaluation.

RCT

2007·

52citations

·T. Zesiewicz et al.

Neurotoxic Assessment of Chronic Abuse of Pregabalin in Wistar Rats

Prolonged abuse of pregabalin can cause neurotoxic effects by dysregulating brain neurochemicals, causing inflammation, and promoting apoptosis in Wistar rats.

RCTAnimal Study

2021·

3citations

·N. Salem et al.

Effects of lyric analysis interventions on treatment motivation in patients on a detoxification unit: a randomized effectiveness study.

A single group-based music therapy lyric analysis session can effectively enhance treatment motivation in patients on a detoxification unit, regardless of the song used.

RCT

2015·

27citations

·Michael J. Silverman

A critical appraisal of controlled studies investigating malformation risks following pregabalin use in early pregnancy

Pregabalin use in early pregnancy may have a small increased risk of malformations, but the evidence is low quality and insufficient to justify product literature updates.

Systematic ReviewVery Rigorous Journal

2022·

4citations

·J. Richardson et al.

How the Pregabalin (Lyrica) Administration as an Abuse Drug Can Affects the Reproductive Health of Male Wistar Rat

Addiction to pregabalin (Lyrica) negatively impacts male reproductive health and fertility by hindering hormone secretion, raising reactive oxygen species, and causing DNA damage and testicular histology.

RCTAnimal Study

2021·

0citations

·Nouf Bader Alduweesh

SAT0487 A randomized, blinded, comparator-controlled trial investigating a 4-week course of lyrica in subjects with knee osteoarthritis who exhibit neuropathic pain, compared with a 4-week course of paracetamol

Pregabalin (300mg) is more effective in reducing pain and improving function than paracetamol in people with knee osteoarthritis who exhibit neuropathic pain.

RCT

2017·

3citations

·A. Wright et al.

Listening to Lyrica: contested illnesses and pharmaceutical determinism.

Pharmaceutical determinism, influenced by Lyrica's approval, promotes and legitimizes contested illnesses, highlighting the need for patients to challenge the industry's role in illness validation.

Rigorous JournalHighly Cited

2011·

79citations

·K. Barker

Margaret McCartney: Second use patents—why do we have to prescribe branded Lyrica for pain?

Prescription of generic pregabalin for pain is illegal due to Pfizer's second use patent, despite being cheaper.

Rigorous Journal

2015·

3citations

·M. McCartney

LYRICA NIGHTS–RECREATIONAL PREGABALIN ABUSE IN AN URBAN EMERGENCY DEPARTMENT

Pregabalin recreational abuse can lead to seizures and ICU admissions, requiring emergency physicians to be aware of its use and potential toxicity.

Case ReportRigorous Journal

2013·

41citations

·J. Millar et al.

A DFT investigation of structure, spectroscopic properties and tautomerism of the anticonvulsant drug Lyrica.

The most stable conformer of Lyrica is the L1 (-OH form), which can be tautomerized to the L5 (-NH form), with DFT-based calculations in agreement with experimental values.

2015·

16citations

·Zohre Sadeghzade et al.

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