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These studies suggest that nausea can be a sign of stroke, particularly in cases of ischemic stroke and acute vestibular syndrome.
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Stroke is a medical emergency characterized by the sudden loss of blood flow to the brain, leading to neurological deficits. While classic symptoms such as facial drooping, arm weakness, and speech difficulties are well-known, other less typical symptoms can also indicate a stroke. One such symptom is nausea, which has been increasingly recognized in various studies.
Nausea is frequently associated with posterior circulation strokes, which affect the back part of the brain, including the brainstem and cerebellum. These strokes often present with acute vestibular syndrome (AVS), characterized by vertigo, nystagmus, gait unsteadiness, and nausea or vomiting . The Head Impulse–Nystagmus–Test of Skew (HINTS) examination is a valuable tool in differentiating posterior circulation strokes from peripheral causes of AVS, with high sensitivity and specificity .
Research has shown that even small strokes in the posterior circulation can cause significant symptoms, including severe vertigo and nausea. These small strokes often affect central vestibular structures and can be challenging to diagnose with early MRI, which may yield false negatives. The HINTS examination has proven more effective than early MRI in identifying these small strokes .
The National Institutes of Health Stroke Scale (NIHSS) is commonly used to assess stroke severity, but it does not capture all possible symptoms. Studies have found that patients with an NIHSS score of 0 can still experience symptoms such as headache, vertigo, and nausea, particularly when the posterior circulation is involved. This highlights the importance of considering a broader range of symptoms in stroke diagnosis.
Women may experience unique stroke symptoms more frequently than men, including nausea, headache, dizziness, and cognitive dysfunction. These symptoms are often under-recognized, leading to delays in diagnosis and treatment. Improving the sensitivity of stroke assessment tools to these unique symptoms could enhance early detection and outcomes for women.
Emergency medical services (EMS) often struggle to identify strokes that do not present with typical symptoms. A systematic review found that around 25% of stroke patients do not exhibit the classic "face, arm, speech" symptoms, making prehospital identification challenging. Nausea and vomiting were among the commonly documented symptoms in these false-negative cases. Enhancing EMS training and stroke screening tools to include a wider range of symptoms could improve diagnostic accuracy.
Non-pharmacological interventions, such as Benson's relaxation therapy combined with a head-up 30-degree position, have been shown to reduce nausea in post-ischemic stroke patients. These therapies can complement anti-emetic drugs and improve patient compliance with nausea management.
Nausea is a significant but often overlooked symptom of stroke, particularly in cases involving the posterior circulation. Recognizing and accurately diagnosing stroke in patients presenting with nausea can be challenging but is crucial for timely and effective treatment. Incorporating a broader range of symptoms into stroke assessment tools and improving EMS training can enhance early detection and outcomes for stroke patients.
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