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These studies suggest that chronic kidney disease (CKD) is a prevalent and progressive public health issue with significant cardiovascular risks, and that prevention and management should focus on early detection, risk factor modification, and healthy dietary patterns.
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Chronic kidney disease (CKD) is a significant global health burden, affecting approximately 11-13% of the global population. The majority of these cases are in stage 3, characterized by a glomerular filtration rate (GFR) of 30-59 mL/min per 1.73 m². CKD is often asymptomatic until its later stages, making early detection challenging. The disease is associated with increased risks of cardiovascular morbidity, premature mortality, and decreased quality of life .
The primary causes of CKD globally are diabetes and hypertension, which are prevalent in both high-income and low-income countries . Other contributing factors include exposure to nephrotoxins, structural abnormalities of the kidney, and environmental risk factors. The incidence and progression of CKD also vary by ethnicity and social determinants of health, with disadvantaged populations being at higher risk .
CKD poses a substantial economic burden on healthcare systems. In high-income countries, the costs of dialysis and transplantation can consume up to 3% of the annual healthcare budget. The disease is projected to become the 5th most common cause of years of life lost globally by 2040. The rising prevalence of CKD is closely linked to increases in obesity, diabetes, and hypertension.
Preventive measures are crucial in managing CKD. Primary prevention focuses on modifying risk factors such as diabetes, hypertension, and obesity, and addressing environmental exposures . Secondary prevention involves early detection and management of CKD risk factors to slow disease progression. Screening for CKD through routine laboratory tests can help identify individuals at risk and initiate early treatment .
Diet plays a significant role in CKD prevention. Healthy dietary patterns, including the consumption of plant-based foods, coffee, and dairy, are associated with a lower risk of CKD. Conversely, diets high in red and processed meats and sugar-sweetened beverages may promote kidney function loss. More research is needed to understand the effects of specific food groups on kidney health.
Management of CKD involves controlling blood pressure, optimizing glycemic control, and managing co-morbidities such as cardiovascular disease and uremia. Interventions targeting specific symptoms and supporting educational or lifestyle changes can improve the quality of life for CKD patients. Early intervention and consistent management strategies are essential to delay the progression of CKD and reduce associated health risks.
CKD is a growing global health issue with significant economic and public health implications. Early detection, preventive measures, and effective management strategies are crucial in mitigating the impact of CKD. Increased awareness and coordinated efforts at the national and global levels are needed to address this pervasive health challenge.
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