Laxatives for constipation
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Types of Laxatives for Constipation: Bulk-Forming, Osmotic, and Stimulant Laxatives
Laxatives are commonly used to treat constipation and are generally divided into three main types: bulk-forming, osmotic, and stimulant laxatives. Bulk-forming laxatives, such as psyllium and bran, work by increasing stool bulk and are often recommended as a first-line treatment, especially when combined with increased fluid intake and dietary fiber 1369. Osmotic laxatives, including polyethylene glycol (PEG), lactulose, and magnesium salts, draw water into the bowel to soften stools and are supported by strong evidence for effectiveness and safety, particularly PEG, which is considered a first-line option for both adults and elderly patients 14568. Stimulant laxatives, such as senna and bisacodyl, increase intestinal muscle contractions to promote bowel movements and are also effective, with senna receiving a high grade of recommendation 1456.
Effectiveness and Safety of Laxatives
Research consistently shows that both osmotic and stimulant laxatives are more effective than placebo for treating chronic constipation in adults, children, and the elderly 1456. PEG and senna have the strongest evidence for efficacy, while other options like magnesium salts, bisacodyl, and sodium picosulfate have moderate support 146. In elderly patients, PEG is noted for its safety and effectiveness even with long-term use . Common side effects across all laxative types include diarrhea, nausea, bloating, and abdominal pain, but serious adverse events are rare 146.
Laxative Foods and Lifestyle Modifications
Dietary and lifestyle changes are often recommended as the first step in managing constipation. Increasing dietary fiber and fluid intake, along with regular exercise, can help improve bowel function. Laxative foods such as prunes, figs, kiwifruit, bran, flaxseed, and certain probiotics and prebiotics have shown beneficial effects and can be a convenient alternative or complement to pharmacological treatments 13. These foods are especially useful for mild constipation and as part of a long-term management plan .
Laxatives in Special Populations: Palliative Care and Community Use
In palliative care, constipation is common and can cause significant discomfort. Studies show that various laxatives—including lactulose, senna, co-danthramer, and magnesium hydroxide—are similarly effective, but there is no clear evidence that one is superior to another 278. Bulk-forming laxatives are generally not recommended in palliative care due to fluid intake limitations . In the community, many adults self-manage constipation with over-the-counter laxatives, but about half find them effective, and healthcare professionals are not always involved in the selection process .
Newer Pharmacological Therapies
For chronic constipation that does not respond to traditional laxatives, newer medications such as prucalopride, lubiprostone, and linaclotide have been shown to be more effective than placebo 4610. These drugs are particularly useful for patients with chronic idiopathic constipation or opioid-induced constipation, where standard laxatives may not be sufficient .
Conclusion
Laxatives are effective and generally safe for treating constipation, with PEG and senna being the most strongly supported options. Dietary and lifestyle modifications, including the use of laxative foods, are important first steps. In special populations like the elderly and those in palliative care, careful selection and monitoring are needed. Newer pharmacological agents offer additional options for refractory cases. In all cases, the choice of laxative should consider both efficacy and patient preference, with healthcare professional guidance improving outcomes 13456789+1 MORE.
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