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These studies suggest lung cancer is the leading cause of cancer death globally, primarily due to tobacco use.
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Cancer has emerged as one of the leading causes of premature death worldwide, surpassing cardiovascular disease (CVD) in many countries. Currently, cancer is the leading cause of death in 57 countries, including China, while CVD leads in 70 countries, such as Brazil and India. This shift is part of an epidemiologic transition where noncommunicable diseases are replacing infectious diseases as the primary health concern.
The global burden of cancer is substantial and continues to grow. In 2012, there were approximately 14.1 million new cancer cases and 8.2 million cancer-related deaths worldwide. This burden is increasingly shifting towards less developed countries, which now account for 57% of cancer cases and 65% of cancer deaths globally. By 2013, the number of new cancer cases had risen to 14.9 million, with 8.2 million deaths and 196.3 million disability-adjusted life years (DALYs).
Lung cancer is the leading cause of cancer death globally, responsible for the highest number of cancer deaths among both men and women. Tobacco smoking is the predominant risk factor, although non-tobacco-related factors such as environmental and occupational exposures also contribute significantly . The incidence of lung cancer in non-smokers, particularly among Asian women, is also on the rise.
Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among females worldwide. In 2015, there were 2.4 million new cases of breast cancer, making it the most common cancer among women. It also accounted for 523,000 deaths and 15.1 million DALYs. In less developed countries, breast cancer has surpassed cervical cancer as the leading cause of cancer death among females.
Prostate cancer is the most common cancer among men, with 1.6 million new cases reported in 2015. It is a significant contributor to cancer incidence but not the leading cause of cancer death among men, which is lung cancer.
Several established risk factors contribute to the leading causes of cancer death. These include tobacco use, overweight/obesity, physical inactivity, and infections. For instance, tobacco use is linked to lung, colorectal, stomach, and liver cancers, while overweight and physical inactivity are associated with breast and colorectal cancers.
Effective prevention measures, such as tobacco control, vaccination, and early detection tests, could prevent a substantial portion of cancer cases and deaths. Public health campaigns promoting physical activity and healthier dietary choices are also crucial .
Cancer remains a major global health challenge, with its incidence and mortality rates continuing to rise, particularly in less developed countries. Lung and breast cancers are the leading causes of cancer death among men and women, respectively. Addressing the modifiable risk factors and implementing effective prevention strategies are essential steps in reducing the global cancer burden. As cancer continues to surpass other diseases as a leading cause of death, comprehensive cancer control policies and increased investment in research are imperative to combat this growing threat.
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