Leukopenia treatment
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Leukopenia Treatment: A Comprehensive Overview
Diyushengbai Tablet (DYT) for Leukopenia
Efficacy and Safety of DYT
Diyushengbai tablet (DYT) has been shown to be effective in preventing and treating leukopenia caused by radiotherapy and chemotherapy. A meta-analysis involving 3,793 cases demonstrated that DYT significantly reduces white blood cell (WBC) suppression and improves WBC counts and neutrophils compared to other oral WBC-elevating drugs and granulocyte colony-stimulating factor (G-CSF) 1. The study concluded that DYT is more effective than other treatments, highlighting its high clinical value.
Acupuncture for Chemotherapy-Induced Leukopenia
Effectiveness of Acupuncture
Acupuncture has been found to ameliorate chemotherapy-induced leukopenia in breast cancer patients. A systematic review and meta-analysis of 10 randomized controlled trials with 650 participants showed that acupuncture significantly increased WBC and neutrophil counts 2. Another meta-analysis involving 1,130 patients confirmed these findings, suggesting that acupuncture can increase WBC count, reduce the incidence of myelosuppression, and improve clinical treatment effectiveness 9. These results support the clinical use of acupuncture for managing chemotherapy-induced leukopenia.
Chinese Herbal Medicine (CHM) for Leukopenia
Efficacy of CHM
Chinese herbal medicine (CHM) has been evaluated for its efficacy in treating chemotherapy-induced leukopenia. A systematic review of 14 randomized controlled trials involving 1,053 patients found that CHM combined with chemotherapy improved WBC, neutrophil, hemoglobin, and platelet counts, as well as the Karnofsky performance scale (KPS) score 3. CHM was also found to be superior to Western medicine in improving clinical outcomes without severe adverse events.
Qijiaoshengbai Capsule (QJSBC)
Qijiaoshengbai capsule (QJSBC) is another Chinese medicine shown to be effective in treating leukopenia. A meta-analysis of 24 randomized controlled trials with 2,692 participants indicated that QJSBC significantly increased WBC, hemoglobin, platelet, and neutrophil counts, and improved bone marrow suppression rate and effective rate 5. These findings suggest that QJSBC combined with conventional treatments can effectively improve clinical outcomes for leukopenia patients.
Other Treatments for Leukopenia
Uncaria tomentosa Extract
The aqueous extract from Uncaria tomentosa (C-Med-100) has been studied in a rat model for its effects on chemically induced leukopenia. The results showed that C-Med-100 treatment led to a more natural recovery of WBC counts compared to Neupogen, a granulocyte colony stimulator, which mainly elevated neutrophil cells 6. This suggests that C-Med-100 may offer a balanced approach to enhancing immune function.
Granulocyte Transfusions
Granulocyte transfusions have been evaluated for their efficacy in treating infections in leukopenic subjects. A study on dogs with radiation-induced leukopenia found that the combination of gentamicin and granulocyte transfusions was the most effective therapy for Pseudomonas aeruginosa pneumonia 7. This supports the utility of granulocyte replacement therapy in managing severe infections in granulocytopenic patients.
Iron Therapy and Leukopenia
Iron therapy, particularly intravenous iron, has been associated with leukopenia as a side effect. A study involving 1,567 cases of iron deficiency anemia treated with intravenous iron found that a small percentage of patients developed leukopenia, neutropenia, or lymphocytopenia 10. Although the clinical significance was limited, this potential side effect warrants further investigation.
Conclusion
The treatment of leukopenia involves various approaches, including traditional Chinese medicines like Diyushengbai tablet and Qijiaoshengbai capsule, acupuncture, and granulocyte transfusions. Each treatment has shown efficacy in increasing WBC counts and improving clinical outcomes. However, further research is needed to validate these findings and explore the potential side effects of treatments like iron therapy.
Sources and full results
Most relevant research papers on this topic
The Efficacy and Safety of Diyushengbai Tablet on Preventing and Treating Leukopenia Caused by Radiotherapy and Chemotherapy Against Tumor: A Systematic Review and Meta-Analysis
Diyushengbai tablet (DYT) is more effective in preventing and treating leukopenia caused by radiotherapy and chemotherapy than other oral WBC-elevating drugs, potentially reducing the need for additional G-CSF application.
Meta-AnalysisEffectiveness of Acupuncture in Relieving Chemotherapy-induced Leukopenia in Patients With Breast Cancer: A Systematic Review With A Meta-Analysis and Trial Sequential Analysis
Acupuncture may help alleviate chemotherapy-induced leukopenia in breast cancer patients by increasing white blood cell and neutrophil levels, regardless of the type of acupuncture applied.
Meta-Analysis
Rigorous JournalChinese Herbal Medicine for Chemotherapy-Induced Leukopenia: A Systematic Review and Meta-Analysis of High-Quality Randomized Controlled Trials
Chinese herbal medicine combined with chemotherapy effectively improves clinical symptoms of chemotherapy-induced leukopenia compared to chemotherapy alone or Western medicine + chemotherapy, with no severe side effects observed.
Meta-AnalysisLeukopenia, lymphopenia, and neutropenia in systemic lupus erythematosus: Prevalence and clinical impact--A systematic literature review.
This systematic literature review is inconclusive on the prevalence and impact of leukopenia, lymphopenia, and neutropenia in SLE patients, and the safety of colony stimulating factors in treating leukopenia.
Systematic Review
Highly CitedQijiaoshengbai Capsule for Leukopenia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Qijiaoshengbai capsule combined therapy effectively improves clinical outcomes for patients with leukopenia compared to conventional chemotherapy, radiotherapy, or conventional treatment.
Meta-AnalysisRigorous JournalTreatment of chemotherapy-induced leukopenia in a rat model with aqueous extract from Uncaria tomentosa.
C-Med-100 and Neupogen effectively treat chemotherapy-induced leukopenia in rats, with C-Med-100 showing a more natural recovery process and overall white blood cell increase.
Non-RCT
Animal StudyHighly CitedExperimental Pseudomonas pneumonia in leukopenic dogs: comparison of therapy with antibiotics and granulocyte transfusions.
Gentamicin plus granulocyte transfusions is the most effective treatment for Pseudomonas pneumonia in leukopenic dogs, with the relative value of granulocyte transfusions depending on the specific antibiotic regimen.
RCTAnimal StudyLeukocyte nadir as a predictive factor for efficacy of adjuvant chemotherapy in breast cancer. Results from the prospective trial SBG 2000–1
Chemotherapy-induced leukopenia is associated with improved distant disease-free survival and overall survival in primary breast cancer patients, even after accounting for chemotherapy doses.
RCT
Large Human TrialEfficacy and safety of acupuncture for chemotherapy-induced leukopenia: A systematic review and meta-analysis
Acupuncture can increase white blood cell count after chemotherapy, reduce myelosuppression, and improve clinical treatment effectiveness, but further research is needed for verification.
Meta-Analysis
Very Rigorous Journal