Lipase amylase bromelain
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The Role and Applications of Lipase, Amylase, and Bromelain in Health and Industry
Low Serum Levels of Lipase and Amylase as Biomarkers for Metabolic Disorders
Metabolic Disorders and Enzyme Levels
Recent research has highlighted the significance of low serum levels of digestive enzymes such as amylase and lipase in the context of metabolic disorders. A systematic review and meta-analysis encompassing 20 studies with 20,916 participants found that individuals with type 2 diabetes mellitus, metabolic syndrome, and overweight/obesity had significantly lower serum levels of amylase compared to healthy individuals . Similarly, both type 1 and type 2 diabetes mellitus were associated with significantly lower serum levels of lipase . These findings suggest that low serum levels of these enzymes could serve as biomarkers for various metabolic disorders, warranting further investigation into their roles in disease pathogenesis.
Impact of Liraglutide on Amylase and Lipase Levels
Liraglutide and Enzyme Activity
Liraglutide, a medication used for weight management, has been shown to affect the activity levels of amylase and lipase. Secondary analyses of pooled data from the SCALE clinical development program revealed that liraglutide treatment led to dose-independent, reversible increases in amylase and lipase levels . Specifically, liraglutide 3.0 mg was associated with a 7% increase in amylase and a 31% increase in lipase levels compared to placebo . Despite these elevations, the study found no predictive value for acute pancreatitis onset based on these enzyme levels, suggesting that routine monitoring of amylase and lipase may not be necessary during liraglutide treatment unless acute pancreatitis is suspected .
Immobilization of Lipase and Amylase for Industrial Applications
Enzyme Immobilization Techniques
The immobilization of enzymes such as lipase and amylase on modified carriers has significant industrial applications. A study focused on immobilizing α-amylase from Bacillus subtilis and lipase from Candida rugosa on modified Na-sepiolite (SEP) demonstrated enhanced enzymatic activity and stability . The modified carriers, prepared with cetrimonium bromide surfactant, showed that immobilized lipase and amylase retained higher activity levels after incubation at elevated temperatures and prolonged storage . These findings indicate the potential for using immobilized enzymes in various industrial processes, including the hydrolysis of olive oil and starch.
Enzyme Activities in Dairy Fermentation
Lactococcus chungangensis in Dairy Products
Enzymes such as amylase, proteinase, and lipase play crucial roles in the fermentation of dairy products. Research comparing the enzyme activities of Lactococcus chungangensis CAU 28(T) with the commonly used Lactococcus lactis ssp. lactis KCTC 3769(T) found that L. chungangensis exhibited higher proteinase and lipase activities, making it a promising candidate for dairy fermentation . Although its amylase activity was lower, the strain's overall enzyme profile suggests its potential utility in enhancing the flavor and texture of dairy products .
Conclusion
The studies reviewed provide valuable insights into the roles and applications of lipase, amylase, and bromelain in both health and industry. Low serum levels of these enzymes are associated with metabolic disorders, while their activity levels can be influenced by medications like liraglutide. Additionally, the immobilization of these enzymes on modified carriers and their application in dairy fermentation highlight their industrial significance. Further research is needed to fully understand their potential and optimize their use in various fields.
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