Lisinopril and anxiety and panic attacks

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Lisinopril and Its Impact on Anxiety and Panic Attacks

Introduction to Lisinopril and Anxiety

Lisinopril, an angiotensin-converting enzyme (ACE) inhibitor, is primarily used to manage hypertension. Recent studies have explored its potential effects beyond blood pressure regulation, particularly its impact on anxiety and panic attacks.

Lisinopril and Anxiety-Like Behavior in Hypertensive Rats

Research involving Dahl Salt-Sensitive (DSS) rats has shown that Lisinopril not only reduces blood pressure but also decreases anxiety-like behavior. In a study where DSS rats were treated with Lisinopril for three months, significant reductions in systolic blood pressure (SBP) and pulse wave velocity (PWV) were observed. Additionally, these rats exhibited increased exploration of the center of an open field, a behavior indicative of reduced anxiety . This suggests that Lisinopril may have a beneficial effect on anxiety-like behavior in hypertensive conditions.

Behavioral Alterations in Spontaneously Hypertensive Rats

Another study focused on spontaneously hypertensive rats (SHR) found that Lisinopril could reverse certain behavioral alterations associated with hypertension. The SHR group treated with Lisinopril showed a normalization of SBP and a partial reversal of anxiety-like behavior. Specifically, Lisinopril reduced the time spent and the frequency of entries into the central area of an open field, which are measures of anxiety-like behavior . This indicates that Lisinopril may help mitigate anxiety symptoms in hypertensive individuals.

Conclusion

The evidence from these studies suggests that Lisinopril, while primarily used for hypertension, may also have positive effects on anxiety and panic attacks. By normalizing blood pressure and reducing anxiety-like behaviors in hypertensive rat models, Lisinopril shows promise as a dual-purpose treatment. Further research is needed to fully understand its impact on anxiety and panic attacks in humans.

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Most relevant research papers on this topic

Abstract P3007: Effect of Anti-Hypertensive Treatment Lisinopril on Central Arterial Stiffness and Anxiety-Like Behavior in Adult Hypertensive Dahl Salt-Sensitive Rats

Lisinopril reduces blood pressure and central arterial stiffness in adult hypertensive Dahl Salt-Sensitive rats, improving cognition and indicating a connection between cardiovascular disorder and cognitive function.

Non-RCTAnimal StudyRigorous Journal

2019·

0citations

·Rachel Fenner et al.

Lisinopril reverses behavioural alterations in spontaneously hypertensive rats.

Lisinopril normalizes blood pressure and partially reverses anxiety-like behavior in spontaneously hypertensive rats.

2019·

2citations

·K. Repova et al.

Refractory Hypertension: Recognition of Psychiatric Comorbidity

Refractory hypertension can be effectively managed with psychiatric medications and group sessions, reducing anxiety and reducing medication intolerance.

Case Report

2003·

1citation

·J. Handler

Escitalopram in the treatment of panic disorder: a randomized, double-blind, placebo-controlled trial.

Escitalopram is an effective, safe, and well-tolerated treatment for panic disorder, significantly improving symptoms and reducing panic attack frequency.

RCTLarge Human TrialHighly Cited

2003·

168citations

·S. Stahl et al.

Effect of alprazolam and diazepam on anxiety and panic attacks in panic disorder: a controlled study.

Alprazolam and diazepam are equally effective in reducing the frequency of panic attacks and severity of generalized anxiety in patients with panic disorder compared to placebo.

RCTHighly Cited

1986·

117citations

·D. Dunner et al.

Psychophysiological factors in panic disorder.

Panic attacks in panic disorder patients are not solely based on peripheral physiological responses, but may represent phobic responses to intense anxiety.

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1984·

60citations

·R. Freedman et al.

Anxiety sensitivity and panic disorder

Elevated anxiety sensitivity is a risk factor for panic and panic disorder, and cognitive behavioral treatment and imipramine can help reduce this risk.

Highly Cited

2002·

660citations

·R. McNally

A cognitive approach to panic.

Panic attacks result from catastrophic misinterpretation of bodily sensations, consistent with major features of panic and related cognitive disturbances.

Literature ReviewHighly Cited

1986·

2268citations

·D. Clark

Effect of fluvoxamine on panic disorder.

Fluvoxamine significantly reduces the number of panic attacks and improves anxiety, depression, and disability in panic disorder patients, but does not affect the severity of attacks.

RCTHighly Cited

1993·

113citations

·R. Hoehn-Saric et al.

States of anxiety and their induction by drugs.

Drug-induced anxiety states can provide useful models for understanding the mechanisms of anxiety and its treatment, potentially identifying high-risk populations.

1986·

47citations

·M. Lader et al.

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