Lisinopril drug class

Pro Research Analysisby

Searched over 200M research papers

Analyzed relevant papers

Lisinopril Drug Class: Angiotensin-Converting Enzyme (ACE) Inhibitor

ACE Inhibitor Drug Class Overview

Lisinopril belongs to the angiotensin-converting enzyme (ACE) inhibitor class of drugs. ACE inhibitors are commonly used to treat high blood pressure (hypertension), heart failure, and to help prevent complications in people with diabetes. These drugs work by blocking the action of the enzyme ACE, which is involved in the production of angiotensin II, a substance that narrows blood vessels and raises blood pressure. By inhibiting this enzyme, ACE inhibitors help relax blood vessels and lower blood pressure 1237.

Lisinopril’s Role and Characteristics as an ACE Inhibitor

Lisinopril is specifically identified as an ACE inhibitor and is used primarily for the treatment of hypertension, congestive heart failure, and to prevent kidney and eye complications in diabetes 1237. Unlike many other ACE inhibitors, lisinopril is not a prodrug, meaning it does not require activation by the liver and is active in its administered form. It is also the least lipophilic among ACE inhibitors and is eliminated mainly by the kidneys, not requiring hepatic metabolism .

Clinical Use and Efficacy

Lisinopril is often compared with other antihypertensive drug classes, such as angiotensin receptor blockers, thiazide diuretics, and calcium channel blockers. Studies show that individual responses to lisinopril and other antihypertensive drugs can vary, but lisinopril remains a key option in personalized blood pressure management . It is also used in combination with other drugs, such as hydrochlorothiazide, to enhance blood pressure control 48.

Safety and Side Effects

ACE inhibitors, including lisinopril, are generally well tolerated. Common side effects for the class include low blood pressure, cough, and high potassium levels. Lisinopril, in particular, has been associated with a lower rate of certain side effects, such as erectile dysfunction, compared to some other antihypertensive medications 35. Additionally, lisinopril may help reduce peripheral edema when used alongside calcium channel blockers .

Conclusion

Lisinopril is a widely used antihypertensive medication that belongs to the angiotensin-converting enzyme (ACE) inhibitor drug class. It is effective for treating high blood pressure, heart failure, and preventing complications in diabetes, with a safety and pharmacokinetic profile that distinguishes it from other ACE inhibitors. Its role in combination therapy and its generally favorable side effect profile make it a cornerstone in the management of hypertension and related conditions 123710.

Sources and full results

Most relevant research papers on this topic

Heterogeneity in Blood Pressure Response to 4 Antihypertensive Drugs: A Randomized Clinical Trial.

Personalized treatment targeting specific antihypertensive drugs can potentially provide an additional 4.4 mm Hg-lower systolic blood pressure for individuals with grade 1 hypertension.

RCT

2023·

40citations

·J. Sundström et al.

Synthesis and Characterization of Compounds Related to Lisinopril

This study identifies and synthesizes an unknown impurity in lisinopril production, as well as three other European Pharmacopoeia 8.4 impurities, to improve lisinopril quality and control.

2015·

1citation

·A. V. Raghava Reddy et al.

Overview of the angiotensin-converting-enzyme inhibitors.

ACE inhibitors play a crucial role in the renin-angiotensin system, with differences in potency, affinity for ACE, pharmacokinetics, and toxicity affecting their pharmacokinetic and safety profiles.

Highly Cited

2000·

93citations

·Robert W. Piepho

Stability indicating RP-HPLC method development and validation for estimation of antihypertension class of drugs lisinopril and hydrochlorothiazide

This study developed and validated a stable RP-HPLC method for estimating lisinopril and hydrochlorothiazide in drug substances and drug products, with oxidative degradation being more significant than other stress conditions.

2022·

0citations

·V. P. Chary et al.

(158) Antihypertensive Medications and Erectile Dysfunction: Is this Association Accurate?

Antihypertensive medications are not consistently associated with erectile dysfunction, with higher rates found in ramipril and bisoprolol and lower rates in lisinopril.

2024·

1citation

·J. Visingardi et al.

Study of the dissolution kinetics of drugs in solid dosage form with lisinopril and atorvastatin and intestinal permeability to assess their equivalence in vitro

In vitro studies confirm the equivalence of 10 mg lisinopril and 10 mg atorvastatin tablets, indicating their successful combination for treating chronic heart failure and hypertension.

2022·

1citation

·N. Shulyak et al.

Molecular Mechanics Potential Energy Function of Angiotensin-Converting Enzyme (ACE) Inhibitor, Lisinopril

Lisinopril's most feasible potential energy for acting as an angiotensin-converting enzyme (ACE) inhibitor is 78.73178401 kcal/mol, which is used in treating hypertension, congestive heart failure, and heart attacks.

2014·

0citations

·I. Otuokere

Glyceroniosomes for enhanced intestinal absorption of hydrochlorothiazide and lisinopril in their fixed dose combination

Glyceroniosomes enhance the intestinal absorption of hydrochlorothiazide and lisinopril in their fixed dose combination, with tween-based systems being more efficient.

In Vitro Study

2024·

0citations

·Aya R Elbasuony et al.

Effect on the Gastrointestinal Absorption of Drugs from Different Classes in the Biopharmaceutics Classification System, When Treating with Liraglutide.

Liraglutide delays gastrointestinal absorption of oral drugs, but overall plasma exposure changes are minor and not clinically relevant.

RCT

2015·

27citations

·M. Malm-Erjefält et al.

Prevalence of Calcium Channel Blocker Induced Ankle Edema and its Treatment in a Cohort of Newly Diagnosed Hypertensive Patients

Lisinopril addition to calcium channel blocker therapy significantly reduces the incidence and severity of peripheral edema in newly diagnosed hypertensive patients.

RCT

2022·

0citations

·P. Onah et al.

Try another search

formation of snow in the atmosphere

tachyons faster than light theoretical physics

causes of low HDL cholesterol

omeprazole and calcium carbonate drug interaction

weight loss strategies for gradual weight reduction

topical treatments for allergic skin reactions

Lisinopril drug class

Pro Research Analysisby

Lisinopril Drug Class: Angiotensin-Converting Enzyme (ACE) Inhibitor

ACE Inhibitor Drug Class Overview

Lisinopril’s Role and Characteristics as an ACE Inhibitor

Clinical Use and Efficacy

Safety and Side Effects

Conclusion

Sources and full results

Heterogeneity in Blood Pressure Response to 4 Antihypertensive Drugs: A Randomized Clinical Trial.

Personalized treatment targeting specific antihypertensive drugs can potentially provide an additional 4.4 mm Hg-lower systolic blood pressure for individuals with grade 1 hypertension.

Synthesis and Characterization of Compounds Related to Lisinopril

This study identifies and synthesizes an unknown impurity in lisinopril production, as well as three other European Pharmacopoeia 8.4 impurities, to improve lisinopril quality and control.

Overview of the angiotensin-converting-enzyme inhibitors.

ACE inhibitors play a crucial role in the renin-angiotensin system, with differences in potency, affinity for ACE, pharmacokinetics, and toxicity affecting their pharmacokinetic and safety profiles.

Stability indicating RP-HPLC method development and validation for estimation of antihypertension class of drugs lisinopril and hydrochlorothiazide

This study developed and validated a stable RP-HPLC method for estimating lisinopril and hydrochlorothiazide in drug substances and drug products, with oxidative degradation being more significant than other stress conditions.

(158) Antihypertensive Medications and Erectile Dysfunction: Is this Association Accurate?

Antihypertensive medications are not consistently associated with erectile dysfunction, with higher rates found in ramipril and bisoprolol and lower rates in lisinopril.

﻿Study of the dissolution kinetics of drugs in solid dosage form with lisinopril and atorvastatin and intestinal permeability to assess their equivalence in vitro

In vitro studies confirm the equivalence of 10 mg lisinopril and 10 mg atorvastatin tablets, indicating their successful combination for treating chronic heart failure and hypertension.

Molecular Mechanics Potential Energy Function of Angiotensin-Converting Enzyme (ACE) Inhibitor, Lisinopril

Lisinopril's most feasible potential energy for acting as an angiotensin-converting enzyme (ACE) inhibitor is 78.73178401 kcal/mol, which is used in treating hypertension, congestive heart failure, and heart attacks.

Glyceroniosomes for enhanced intestinal absorption of hydrochlorothiazide and lisinopril in their fixed dose combination

Glyceroniosomes enhance the intestinal absorption of hydrochlorothiazide and lisinopril in their fixed dose combination, with tween-based systems being more efficient.

Effect on the Gastrointestinal Absorption of Drugs from Different Classes in the Biopharmaceutics Classification System, When Treating with Liraglutide.

Liraglutide delays gastrointestinal absorption of oral drugs, but overall plasma exposure changes are minor and not clinically relevant.

Prevalence of Calcium Channel Blocker Induced Ankle Edema and its Treatment in a Cohort of Newly Diagnosed Hypertensive Patients

Lisinopril addition to calcium channel blocker therapy significantly reduces the incidence and severity of peripheral edema in newly diagnosed hypertensive patients.

Try another search

Study of the dissolution kinetics of drugs in solid dosage form with lisinopril and atorvastatin and intestinal permeability to assess their equivalence in vitro