Lisinopril effects on lipid profile
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Lisinopril and Lipid Profile: Effects in Hypertension and Other Conditions
Lisinopril Effects on Total Cholesterol and LDL Cholesterol
Several studies have examined the impact of lisinopril, an ACE inhibitor, on lipid profiles in both animal models and human patients. In animal studies, lisinopril was shown to decrease total cholesterol by about 3.1% and LDL cholesterol by up to 8.6% over a 6-week period, suggesting a modest but favorable effect on these lipid parameters . In patients with chronic nephropathies, increasing lisinopril doses led to significant, dose-dependent reductions in total cholesterol and LDL cholesterol, especially in those with more severe hypoalbuminemia . However, other clinical studies in hypertensive patients found no significant changes in total cholesterol or LDL cholesterol after both short- and long-term lisinopril therapy 27810.
Lisinopril and HDL Cholesterol
Some research indicates that lisinopril may increase HDL cholesterol. In animal studies, a rise in HDL levels was observed after lisinopril treatment . In hypertensive patients, a significant increase in HDL cholesterol was also reported after three months of lisinopril therapy . However, other studies did not find significant changes in HDL cholesterol with lisinopril use 27810.
Lisinopril and Triglycerides
The effect of lisinopril on triglycerides appears to be minimal or inconsistent. In animal studies, there was no significant change in serum triglyceride levels with lisinopril . In patients with chronic nephropathies, lisinopril reduced triglyceride levels in a dose-dependent manner . However, most studies in hypertensive patients found no significant effect of lisinopril on triglyceride concentrations 27810.
Lisinopril in Combination Therapy
When lisinopril was used in combination with other drugs, such as amlodipine and rosuvastatin, a greater improvement in lipid profile was observed, including a 14.5% reduction in total cholesterol and a 31.4% reduction in LDL cholesterol over 24 weeks in hypertensive patients with dyslipidemia who had recovered from COVID-19 . However, when combined with hydrochlorothiazide, lisinopril was associated with an increase in total cholesterol and a decrease in HDL cholesterol .
Lisinopril Compared to Other Antihypertensive Agents
Compared to other antihypertensive drugs, lisinopril generally does not adversely affect lipid metabolism. Studies comparing lisinopril to bisoprolol, trichlormethiazide, and moxonidine found no significant changes in lipid profiles with lisinopril, while some other agents showed less favorable or neutral effects 8910.
Conclusion
Overall, lisinopril appears to have a neutral to mildly beneficial effect on lipid profiles, with some studies showing small reductions in total and LDL cholesterol and possible increases in HDL cholesterol. The effects on triglycerides are less consistent. Lisinopril does not seem to adversely affect lipid metabolism and may be a suitable antihypertensive agent for patients concerned about their lipid profile, especially when compared to some other antihypertensive medications 12345789+1 MORE.
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