Lisinopril side effects in men
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Lisinopril Side Effects in Men
Common Side Effects of Lisinopril in Men
Blood Pressure and Heart Rate Changes
Lisinopril, an angiotensin-converting enzyme (ACE) inhibitor, is commonly used to manage hypertension. Studies have shown that lisinopril effectively lowers both systolic and diastolic blood pressure in men 146. However, it can also cause an initial increase in heart rate, particularly when combined with other medications like nifedipine .
Sexual Dysfunction
One notable side effect of lisinopril in men is its impact on sexual function. Research indicates that lisinopril can cause a temporary decline in sexual activity, although this effect tends to diminish over time. In a study comparing lisinopril to atenolol, men treated with lisinopril initially experienced a reduction in the number of sexual intercourse episodes per month, but this effect was not sustained, and sexual activity levels eventually returned to baseline . Additionally, the incidence of sexual dysfunction symptoms was significantly lower in men treated with lisinopril compared to those treated with atenolol .
Cough
Cough is another side effect associated with lisinopril, although it appears to be more prevalent in women than in men. In a study involving hypertensive patients, 8.5% of those treated with lisinopril reported experiencing a cough, with men reporting this side effect less frequently than women (4.4% vs. 12.6%) .
Renal and Cardiometabolic Effects
Lisinopril has been shown to influence renal function and cardiometabolic risk factors. In men with asymptomatic left ventricular dysfunction, lisinopril improved cardiopulmonary response to exercise and increased renal blood flow, although it also led to a decline in glomerular filtration rate . Furthermore, in men with hypertension and early-onset androgenetic alopecia, lisinopril reduced blood pressure and markers of inflammation, but its effects on cardiometabolic risk factors were less pronounced compared to men without alopecia .
Fertility
Interestingly, lisinopril may have a positive effect on male fertility. A pilot study found that low-dose lisinopril improved seminal parameters in men with idiopathic oligospermia, increasing total sperm count and motility while reducing the percentage of sperm with abnormal morphology. This led to a pregnancy rate of 48.5% among the participants, suggesting that lisinopril could enhance fertility in some men .
Conclusion
Lisinopril is effective in managing hypertension and has several side effects in men, including temporary sexual dysfunction, cough, and changes in renal function. However, it may also offer benefits such as improved fertility in men with idiopathic oligospermia. Understanding these side effects can help in making informed decisions about the use of lisinopril in male patients.
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