Low vit d normal calcium
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Low Vitamin D with Normal Calcium: Insights from Recent Research
Vitamin D and Calcium Metabolism in Infants
Research on infants receiving parenteral nutrition (PN) with low vitamin D content has shown that normal calcium levels can be maintained despite low vitamin D intake. A study involving infants with surgical indications for PN found that both high and low calcium and phosphorus groups maintained normal serum calcium, magnesium, phosphorus, and other related markers. Interestingly, the study noted that low calcium and phosphorus intake led to an adaptive increase in 1,25-dihydroxyvitamin D and tubular reabsorption of phosphorus, suggesting a compensatory mechanism to maintain calcium homeostasis .
Vitamin D Status in Young Adults
A study conducted in Saudi Arabia among male university students revealed a prevalent low vitamin D status despite normal serum calcium levels. The research indicated that a significant portion of the population had serum 25-hydroxyvitamin D levels below 10 ng/ml, yet their calcium levels remained within the normal range. This suggests that low vitamin D levels do not necessarily correlate with hypocalcemia in this demographic .
Impact of Dietary Calcium and Vitamin D on Mineral Metabolism
In an animal study, varying levels of dietary calcium and vitamin D were shown to affect the metabolism of several minerals. Rats fed with different levels of calcium and vitamin D exhibited significant changes in the absorption rates of calcium, phosphorus, magnesium, and other minerals. The study highlighted that higher dietary calcium levels decreased the absorption rates of these minerals, while increased vitamin D levels led to higher fecal excretion of phosphorus .
Vitamin D and Calcium Supplementation in HIV-Infected Adolescents
A clinical trial among Thai adolescents with perinatally acquired HIV infection demonstrated that both standard and high-dose vitamin D and calcium supplementation significantly increased lumbar spine bone mineral density (LSBMD). The study found that higher doses of vitamin D and calcium were more effective in improving LSBMD z-scores, indicating the importance of adequate supplementation for bone health in this population .
Calcium Absorption and Vitamin D Levels
Research has shown that calcium absorption varies significantly within the reference range for serum 25-hydroxyvitamin D. A study found that individuals with higher serum 25-hydroxyvitamin D levels (86.5 nmol/L) had a 65% higher calcium absorption compared to those with lower levels (50 nmol/L). This suggests that even within the normal range, higher vitamin D levels can enhance calcium absorption, which is crucial for bone health .
Vitamin D Depletion Post-Gastric Bypass Surgery
A study on morbidly obese women post-Roux-en-Y gastric bypass surgery found that weekly supplementation with 50,000 IU of vitamin D significantly improved vitamin D levels and reduced the prevalence of vitamin D depletion. Despite normal calcium supplementation, vitamin D depletion persisted in a significant portion of patients without additional high-dose vitamin D, highlighting the need for aggressive vitamin D supplementation in this group .
Vitamin D and Calcium in Subclinical Hypothyroidism
In patients with subclinical hypothyroidism, lower levels of serum vitamin D and calcium were observed compared to healthy controls. This suggests a potential link between thyroid function and vitamin D and calcium metabolism, although the exact mechanisms remain to be fully understood .
Calcium and Vitamin D Insufficiencies in Bone Health
An analysis of the Korean National Health and Nutrition Examination Survey revealed that low dietary calcium intake and low serum 25-hydroxyvitamin D levels were associated with higher serum parathyroid hormone levels and lower bone mineral density. This underscores the importance of adequate calcium and vitamin D intake for maintaining bone health, especially in populations with low dietary calcium intake .
Role of Vitamin D and Calcium in Dysmenorrhea
A systematic review found that low levels of vitamin D and calcium are associated with increased severity of primary dysmenorrhea. Supplementation with vitamin D and calcium was shown to reduce the severity of dysmenorrhea and the need for analgesics, suggesting a beneficial role for these nutrients in managing menstrual pain .
Vitamin D Levels in Children with Fractures
A study in Irish children with fractures found no significant difference in vitamin D levels between those with fractures and controls. However, a substantial proportion of children with fractures had low vitamin D levels, indicating that vitamin D status may influence fracture risk in pediatric populations .
Conclusion
The research collectively indicates that while low vitamin D levels are common in various populations, normal calcium levels can often be maintained through compensatory mechanisms. However, adequate vitamin D and calcium intake are crucial for optimal bone health and metabolic function, particularly in vulnerable groups such as infants, adolescents with HIV, and individuals post-gastric bypass surgery. Regular monitoring and appropriate supplementation of these nutrients are essential to prevent deficiencies and associated health issues.
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