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These studies suggest that dietary nitrate, calcium, magnesium, taurine, vitamins C and E, potassium, and DHA supplements can lower blood pressure, while vitamin D3 and vitamin E show minimal or no significant effects.
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Dietary nitrate, commonly found in beetroot juice, has been shown to significantly lower blood pressure in hypertensive patients. A randomized, double-blind, placebo-controlled study demonstrated that daily supplementation with dietary nitrate resulted in a reduction of clinic blood pressure by 7.7/2.4 mm Hg, 24-hour ambulatory blood pressure by 7.7/5.2 mm Hg, and home blood pressure by 8.1/3.8 mm Hg over a 4-week period. Another systematic review and meta-analysis confirmed that inorganic nitrate and beetroot juice supplementation significantly reduced systolic blood pressure by 4.4 mm Hg and diastolic blood pressure by 1.1 mm Hg.
A systematic review and meta-analysis investigated the effects of various vitamins and minerals on blood pressure. Calcium and magnesium were found to significantly reduce both systolic and diastolic blood pressure. Specifically, calcium reduced systolic blood pressure by 1.37 mm Hg and diastolic blood pressure by 1.63 mm Hg, while magnesium reduced systolic blood pressure by 2.79 mm Hg and diastolic blood pressure by 1.56 mm Hg. Potassium supplementation also showed a significant reduction in systolic blood pressure by 5.9 mm Hg and diastolic blood pressure by 3.4 mm Hg, with more pronounced effects in hypertensive patients.
Taurine, a sulfur-containing amino acid, has shown promise in lowering blood pressure in prehypertensive individuals. A randomized, double-blind, placebo-controlled study found that taurine supplementation significantly decreased clinic systolic blood pressure by 7.2 mm Hg and diastolic blood pressure by 4.7 mm Hg. Additionally, 24-hour ambulatory blood pressure was reduced by 3.8 mm Hg systolic and 3.5 mm Hg diastolic.
The role of antioxidant vitamins in blood pressure management has been explored with mixed results. A meta-analysis of randomized controlled trials found that vitamin C supplementation reduced systolic blood pressure by 3.84 mm Hg and diastolic blood pressure by 1.48 mm Hg. Another study indicated that combined supplementation of vitamins C and E significantly lowered both systolic and diastolic blood pressure in patients with essential hypertension, likely due to their antioxidant properties.
Omega-3 fatty acids, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have been studied for their effects on blood pressure. A 12-week randomized trial found that DHA supplementation reduced systolic blood pressure by 3.4 mm Hg and diastolic blood pressure by 3.4 mm Hg, while EPA did not show significant reductions. Interestingly, DHA also increased muscle sympathetic nerve activity, suggesting a complex interaction with cardiovascular regulation.
Various supplements, including dietary nitrate, certain vitamins and minerals, taurine, and omega-3 fatty acids, have demonstrated potential in lowering blood pressure. While dietary nitrate and beetroot juice show strong evidence for reducing blood pressure in hypertensive patients, calcium, magnesium, and potassium also offer significant benefits. Taurine and antioxidant vitamins like C and E can be effective, particularly in specific populations such as prehypertensive individuals and those with essential hypertension. Omega-3 fatty acids, especially DHA, may also contribute to blood pressure reduction, though their mechanisms require further exploration. These findings suggest that incorporating these supplements could be a valuable adjunctive strategy in managing blood pressure.
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