How Can I Lower My Triglyceride Levels?

Introduction

Elevated triglyceride levels are a significant risk factor for cardiovascular disease (CVD). Various strategies, including lifestyle changes, dietary modifications, and pharmacological interventions, have been studied to lower triglyceride levels and reduce associated health risks.

Key Insights

Omega-3 Fatty Acids:
- Icosapent ethyl, a high-purity prescription form of the omega-3 fatty acid eicosapentaenoic acid (EPA), significantly reduces triglyceride levels without increasing low-density lipoprotein cholesterol levels .
Probiotics:
- Probiotics such as Lactobacillus plantarum KY1032 and Lactobacillus curvatus HY7601 have been shown to lower triglyceride levels in both animal models and human subjects with hypertriglyceridemia .
Pharmacological Interventions:
- Pemafibrate, a selective peroxisome proliferator-activated receptor α modulator, reduces triglyceride levels but does not significantly lower the incidence of cardiovascular events.
Dietary Modifications:
- Both high-fat and low-fat diets can lower triglyceride levels, but their effectiveness may depend on the baseline triglyceride levels of individuals. High-fat diets are more effective for those with slightly elevated triglyceride levels, while low-fat diets may be better for those with more distinctly elevated levels.
- Reducing overall fat intake, eliminating trans fats, increasing omega-3 polyunsaturated fatty acids (PUFAs), and replacing refined carbohydrates with fiber-rich foods can significantly lower triglyceride levels.
Lifestyle Changes:
- Regular physical activity can lower triglyceride levels by approximately 20%, independent of caloric intake .
- A 5-10% reduction in body weight can reduce triglyceride levels by 20-30%.

Conclusion

To lower triglyceride levels effectively, a combination of lifestyle changes, dietary modifications, and possibly pharmacological interventions can be employed. Omega-3 fatty acids and probiotics have shown significant promise in reducing triglyceride levels. Additionally, both high-fat and low-fat diets can be effective, depending on individual baseline triglyceride levels. Regular physical activity and weight loss are also crucial strategies for managing triglyceride levels and improving overall cardiometabolic health.

Summary

Not a yes or no question

Introduction

Key Insights

Conclusion

Sources and full results

Usefulness of Icosapent Ethyl (Eicosapentaenoic Acid Ethyl Ester) in Women to Lower Triglyceride Levels (Results from the MARINE and ANCHOR Trials).

Triglycerides and cardiovascular disease: a scientific statement from the American Heart Association.

Triglyceride-Lowering Effects of Two Probiotics, Lactobacillus plantarum KY1032 and Lactobacillus curvatus HY7601, in a Rat Model of High-Fat Diet-Induced Hypertriglyceridemia.

The triglyceride-lowering effect of supplementation with dual probiotic strains, Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032: Reduction of fasting plasma lysophosphatidylcholines in nondiabetic and hypertriglyceridemic subjects.

Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk.

Individual serum triglyceride responses to high-fat and low-fat diets differ in men with modest and severe hypertriglyceridemia.

Lowering triglycerides to modify cardiovascular risk: will icosapent deliver?

Lifestyle Approaches to Lowering Triglycerides

Prescription Omega-3-Acid Ethyl Esters for the Treatment of Very High Triglycerides

Plasma triglyceride lowering by exercise despite increased food intake in patients with type IV hyperlipoproteinemia.

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