Mav migraine
Pro Research Analysisby 
Searched over 200M research papers for "mav migraine"
Migraine with Aura and Migraine-Associated Vertigo: Insights from Recent Research
Introduction to Migraine with Aura (MA)
Migraine with aura (MA) is a subtype of migraine characterized by transient neurological symptoms that usually precede the headache phase. These symptoms often include visual disturbances, sensory changes, and speech difficulties. MA is distinct from migraine without aura (MO) in its presentation and potential underlying mechanisms.
Pulmonary Arteriovenous Malformations and MA
Recent studies have highlighted a significant association between pulmonary arteriovenous malformations (PAVMs) and MA, particularly in patients with hereditary hemorrhagic telangiectasia (HHT). In a cohort of 220 HHT patients, those with PAVMs had a higher prevalence of MA (24%) compared to those without PAVMs (6%)1. This suggests that PAVMs could be an independent predictor for MA, indicating a potential vascular component in the pathophysiology of MA.
Cerebral Vasomotor Reactivity in MA
Alterations in cerebral blood flow (CBF) and vasomotor reactivity (VMR) have been observed in MA patients. Studies using transcranial Doppler (TCD) and near-infrared spectroscopy (NIRS) have shown that MA patients exhibit increased VMR and changes in cerebral blood volume (CBV) and oxygen saturation, particularly on the side of the brain where the migraine predominates2. These findings suggest that impaired cerebrovascular autoregulation may play a role in MA2 3.
Structural Brain Changes in MA
MRI studies have revealed that individuals with MA are more likely to have structural brain abnormalities, such as white matter abnormalities (WMAs) and infarct-like lesions (ILLs), compared to those without migraines or with MO. Meta-analyses have shown a significant association between MA and these structural changes, indicating that MA may be a risk factor for such abnormalities5.
Migraine-Associated Vertigo (MAV)
Migraine-associated vertigo (MAV) is a condition where vertigo episodes are linked to migraine attacks. MAV is more common in females and often presents with episodic vertigo, tinnitus, and aural fullness. Studies have suggested that MAV and Meniere's disease (MD) might share common pathophysiological mechanisms, as evidenced by similar vestibular-evoked myogenic potential (VEMP) responses in patients with both conditions4 6.
Genetic Factors in MAV
Genetic studies have identified a significant association between MAV and the progesterone receptor (PGR) gene. One specific single nucleotide polymorphism (SNP) within the PGR gene has been linked to MAV, suggesting a potential genetic predisposition influenced by female sex hormones8.
Epidemiology and Clinical Features
Epidemiological studies have shown that MA has a lifetime prevalence of about 5%, with a higher incidence in females. Visual disturbances are the most common aura symptoms, and stress is a major precipitating factor for both MA and MO9. In conditions like CADASIL, MA is a prevalent symptom, often presenting with atypical aura symptoms and sometimes occurring without headache10.
Conclusion
The research underscores the complex interplay of vascular, genetic, and structural factors in the pathophysiology of MA and MAV. Understanding these associations can aid in better diagnosis and management of these conditions, highlighting the need for further studies to explore these mechanisms in greater detail.
Sources and full results
Most relevant research papers on this topic
Pulmonary arteriovenous malformations associated with migraine with aura
PAVMs are associated with migraine with aura in hereditary haemorrhagic telangiectasia patients.
Observational Study
Rigorous JournalIncreased Cerebral Vasomotor Reactivity in Migraine With Aura: An Autoregulation Disorder? A Transcranial Doppler and Near-Infrared Spectroscopy Study
Migraine with aura patients show increased cerebral vasomotor reactivity, suggesting altered autoregulation due to impaired cerebrovascular autonomic control.
Observational Study
Highly CitedChanges in Functional Vasomotor Reactivity in Migraine With Aura
Migraine with aura patients show significant asymmetry in functional vasomotor reactivity, reflecting interattack persisting vasomotor changes and potentially useful as a monitoring tool under prophylactic medication.
Observational StudyDoes Migraine-Associated Vertigo Share a Common Pathophysiology With Meniere's Disease? Study With Vestibular-Evoked Myogenic Potential
Migraine-associated vertigo may share a common pathophysiology with Meniere's disease, suggesting different lesion sites in both conditions.
Non-RCTHighly CitedMigraine and structural changes in the brain
Migraine may be a risk factor for structural brain changes, particularly white matter abnormalities and infarct-like lesions.
Meta-Analysis
Very Rigorous JournalHighly CitedMigraine Associated Vertigo
Migraine associated vertigo (MAV) has a diverse pathophysiology and lesion sites, and universal diagnostic criteria and treatment guidelines are needed for its widespread acceptance in Japan.
[The clinical features of migraine-associated vertigo].
Migraine-associated vertigo (MAV) is a new clinical entity in Japan, characterized by migraine attacks before vertigo onset in women aged 30-40 years, with attacks lasting 1-24 hours and no associated hearing loss.
Observational StudyAssociation of progesterone receptor with migraine-associated vertigo
A single SNP within the progesterone receptor gene is significantly associated with migraine-associated vertigo, while two ESR1 variants showed no significant association.
Observational StudyMigraine With Aura and Migraine Without Aura: An Epidemiological Study
Migraine with aura and migraine without aura share the pain phase, with women being more likely to have migraine without aura and stress being a significant precipitating factor in both disorders.
Observational StudyHighly CitedPrevalence and characteristics of migraine in CADASIL
Migraine with aura is present in nearly half of CADASIL patients, often the initial manifestation, and is not associated with the severity of the disorder.
Observational StudyRigorous JournalHighly Cited