Maximum dosage of metoprolol tartrate

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Maximum Dosage of Metoprolol Tartrate: Key Information

Dosage Strengths and Formulations

Metoprolol tartrate is available in several oral tablet strengths, including 25 mg, 37.5 mg, 50 mg, 75 mg, and 100 mg per tablet, depending on the manufacturer 12345. These strengths allow for flexible dosing based on patient needs and clinical indications.

Maximum Recommended Dosage

The maximum dosage of metoprolol tartrate for adults is typically up to 450 mg per day, divided into multiple doses. This upper limit is based on standard prescribing information and clinical practice, although the specific maximum dose may vary depending on the condition being treated, patient response, and tolerance. The most common dosing regimens for hypertension, angina, and other cardiovascular conditions usually do not exceed this amount 12.

Special Considerations

Individualization: Dosage should be individualized based on the patient’s clinical response and tolerability. Lower starting doses are often used, with gradual increases as needed 12.
Pediatric and Special Populations: Lower doses are used in pediatric patients and those with certain medical conditions. Dosing adjustments may also be necessary for elderly patients or those with liver impairment 12.
Formulation Differences: Metoprolol tartrate is available as both immediate-release tablets and as an injectable form for intravenous use, but the maximum oral dosage applies to the tablet form 127.

Safety and Monitoring

Patients should be monitored for side effects such as bradycardia, hypotension, and other adverse reactions, especially at higher doses. Dosage should not be increased beyond the maximum recommended amount without careful medical supervision 12.

Conclusion

The maximum recommended dosage of metoprolol tartrate for adults is generally up to 450 mg per day, divided into several doses, with adjustments based on individual patient needs and tolerability. Always consult a healthcare provider for personalized dosing and monitoring.

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Most relevant research papers on this topic

Metoprolol Tartrate Tablets USP Rx Only Prescribing Information

Metoprolol tartrate tablets contain 25mg, 50mg, or 100mg of metoprolol tartrate and various inactive ingredients for oral administration.

2017·

0citations

METOPROLOL TARTRATE - metoprolol tartrate tablet, film coated Aurolife Pharma LLC ---------- DESCRIPTION Metoprolol tartrate USP is a selective beta -adrenoreceptor blocking agent, available as 25, 50 and 100 mg tablets for oral administration. Metoprolol tartrate is (±)-1-(isopropylamino)-3-[p-(2-

Metoprolol tartrate USP is a selective beta-adrenoreceptor blocking agent available in 25, 50, and 100 mg tablets for oral administration.

2016·

0citations

METOPROLOL TARTRATE TABLETS, USP TruPharma LLC R x only

Metoprolol tartrate tablets, USP, are an oral medication that contains 25mg, 37.5mg, 50mg, 75mg, or 100mg of metoprolol tartrate and various inactive ingredients.

2018·

0citations

METOPROLOL TARTRATE-metoprolol tartrate tablet, film coated Vensun Pharmaceuticals, Inc. R x only

Metoprolol tartrate tablets, film-coated, are an oral medication that contains 25 mg, 50 mg, or 100 mg of metoprolol tartrate and various inactive ingredients for oral administration.

2018·

0citations

MAKALE SPECTROPHOTOMETRIC DETERMINATION OF METOPROLOL TARTRATE IN PURE AND DOSAGE FORMS SAF

The developed spectrophotometric method accurately and simply determines metoprolol tartrate in pure and dosage forms, meeting validation requirements of the State Pharmacopoeia of Ukraine.

2018·

0citations

·S. Vasyuk

METOPROLOL TARTRATE INJECTION, USP

Metoprolol Tartrate Injection, USP, is a selective beta-adrenoreceptor blocking agent available in 5 mL single dose vials for intravenous administration.

2018·

0citations

Comparative bioavailability and effect studies on metoprolol administered as ordinary and slow-release tablets in single and multiple doses.

Slow-release metoprolol tablets have similar bioavailability and pharmacological effects as ordinary tablets, with slower peak plasma levels and slightly higher effects at the end of the dosage interval.

Non-RCT

2009·

61citations

·C. Regårdh et al.

Fundamental Investigations into Metoprolol Tartrate Deposition on Orodispersible Films by Inkjet Printing for Individualised Drug Dosing

Inkjet printing can produce uniform metoprolol tartrate doses on orodispersible films for pediatric use, but nozzle aging may impact the final dose.

2021·

20citations

·Olga Kiefer et al.

Pharmacokinetics and pharmacodynamics of oral and intravenous metoprolol tartrate in clinically healthy horses.

Intravenous and oral metoprolol tartrate in horses have similar pharmacokinetic properties and cardiovascular effects, with sweating as the most common side effect.

RCTAnimal Study

2021·

3citations

·D. Luethy et al.

Estimation of Metoprolol Tartrate and Chlorthalidone in Combined Dosage Form by UV-Spectrophotometric Methods

Two simple, sensitive, rapid, and precise UV spectrophotometric methods have been developed and validated for simultaneous estimation of Metoprolol Tartrate and Chlorthalidone in combined dosage forms, providing accurate and precise results.

2011·

8citations

·H. V. Raval et al.

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