Maximum dose of amlodipine in 24 hours

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Maximum Dose of Amlodipine in 24 Hours

Introduction to Amlodipine and Its Usage in Hypertension

Amlodipine is a long-acting calcium channel blocker commonly used to treat hypertension and angina. It is known for its ability to provide consistent 24-hour blood pressure control with once-daily dosing, making it a popular choice for managing chronic conditions 136.

Recommended Dosage and Efficacy

Standard Dosage

The standard dosage of amlodipine for adults typically starts at 5 mg once daily. This dosage can be increased to 10 mg once daily if necessary to achieve the desired blood pressure control 157. Studies have shown that both 5 mg and 10 mg doses are effective in significantly reducing systolic and diastolic blood pressure over a 24-hour period 136.

Maximum Dosage

The maximum recommended dose of amlodipine in a 24-hour period is 10 mg. Clinical trials and observational studies have consistently used this dosage as the upper limit for evaluating the drug's efficacy and safety 157. For instance, a study involving 104 patients with mild to moderate hypertension demonstrated significant reductions in blood pressure with both 5 mg and 10 mg doses, with the 10 mg dose providing greater reductions .

Safety and Tolerability

Adverse Effects

Amlodipine is generally well-tolerated, with a low incidence of severe adverse effects. Common side effects include peripheral edema, dizziness, and palpitations, but these are typically mild and manageable 2710. In a study comparing different doses, no severe adverse reactions were reported, indicating that even at the maximum dose of 10 mg, amlodipine remains safe for most patients .

Long-Term Use

Long-term studies have shown that amlodipine maintains its efficacy without significant tolerance development. Patients on long-term amlodipine therapy continue to experience stable blood pressure control, making it a reliable option for chronic hypertension management .

Conclusion

In summary, the maximum dose of amlodipine that can be safely administered within a 24-hour period is 10 mg. This dosage has been proven effective in controlling blood pressure throughout the day and night, with a favorable safety profile. Patients and healthcare providers can be confident in the use of amlodipine for long-term hypertension management, adhering to the recommended dosage guidelines to minimize the risk of adverse effects.

Sources and full results

Most relevant research papers on this topic

PS-C10-9: EFFECTIVENESS OF AMLODIPINE ON 24-HOUR AMBULATORY BLOOD PRESSURE IN ADULT PATIENTS WITH MILD-MODERATE ESSENTIAL HYPERTENSION: A MULTICENTRE OBSERVATIONAL, REAL-WORLD STUDY

Amlodipine therapy significantly reduces 24-hour blood pressure in adult patients with mild-to-moderate essential hypertension, improving blood pressure control throughout the day and night.

2023·

0citations

·Prabhakaran Dorairaj et al.

A four-week double-blind, placebo-controlled, parallel dose-response study of amlodipine in patients with stable exertional angina pectoris.

Amlodipine is an effective and well-tolerated once-daily treatment for chronic stable angina, with no severe adverse reactions compared to placebo.

RCT

1989·

19citations

·Stanley H. Taylor et al.

The effect of amlodipine on ambulatory blood pressure in hypertensive patients.

Amlodipine effectively lowers blood pressure consistently throughout a 24-hour period in patients with mild-to-moderate essential hypertension compared to placebo.

RCT

1994·

19citations

·J. Burris et al.

LOSARTAN/AMLODIPINE IN ARTERIAL STIFFNESS SHOWS DOMINANT EFFICACY IN REDUCING 24 HOURS BRACHIAL AND CENTRAL BP COMPARED WITH LOSARTAN/HYDROCHLOROTHIAZID OR IN NORMAL ARTERY

Losartan/amlodipine combination therapy is more effective in reducing 24 hours brachial and central blood pressure in patients with advanced arterial stiffness compared to losartan/hydrochlorothiazide or normal arterial patients.

RCT

2023·

0citations

·E. Cho et al.

Double-blind evaluation of the dose-response relationship of amlodipine in essential hypertension.

Amlodipine effectively reduces diastolic blood pressure in both supine and standing positions, with doses of 2.5, 5.0, or 10.0 mg daily maintaining blood pressure below placebo throughout the 24-hour period.

RCT

1993·

28citations

·Jawahar L. Mehta et al.

24 h blood pressure control with the once daily calcium antagonist, amlodipine.

Amlodipine effectively reduces blood pressure in hypertensive patients over a 24-hour period, with a once-daily dose regimen providing steady state blood levels.

RCT

1989·

46citations

·ME Heber et al.

24-hour blood pressure control with the once-daily calcium antagonist amlodipine.

Amlodipine effectively reduces blood pressure for 24 hours after once-daily dosing and is well tolerated in patients with mild to moderate hypertension.

RCT

1991·

22citations

·E. Raftery et al.

Efficacy and tolerability of initial high vs low doses of S‐(‐)‐amlodipine in hypertension

An initial high dose of S-()-amlodipine improved ambulatory blood pressure control with similar tolerability as an initial low dose in patients with mild or moderate hypertension.

RCTLarge Human Trial

2017·

12citations

·Qi Chen et al.

Effects of dividing amlodipine daily doses on trough drug concentrations and blood pressure control over a 24-hour period.

Divided amlodipine doses did not improve blood pressure control or reduce arterial stiffness in patients with essential hypertension.

2013·

4citations

·K. Miyoshi et al.

Amlodipine in hypertension: an overview of the clinical dossier.

Amlodipine is an effective and well-tolerated antihypertensive drug, providing smooth 24-hour blood pressure control without orthostatic hypotension and being well-tolerated as monotherapy or in combination with other drugs.

Systematic Review

1988·

58citations

·Stevo Julius

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