Maximum recommended dosage of amlodipine
Pro Research Analysisby 
Searched over 200M research papers
Maximum Recommended Dosage of Amlodipine in Hypertension Treatment
Amlodipine Dosage Ranges and Efficacy in Adults
Clinical studies have shown that amlodipine is effective for treating mild to moderate hypertension when given once daily in doses ranging from 2.5 mg to 10 mg. The minimum effective dose is 2.5 mg, while the maximum recommended dose is 10 mg per day. Higher doses do not significantly increase efficacy but may increase the risk of side effects. Most patients achieve good blood pressure control within this range, and the medication is generally well tolerated at these doses, with side effects being mild to moderate in intensity156.
Dose-Response and Safety Considerations
The antihypertensive effect of amlodipine is dose-related, with greater reductions in blood pressure observed at higher doses up to 10 mg daily. Studies comparing 5 mg and 10 mg doses found that increasing to 10 mg can provide additional blood pressure reduction for patients not adequately controlled on 5 mg. However, for some patients, combining amlodipine 5 mg with another antihypertensive (such as bisoprolol) may be as effective or more effective than increasing amlodipine to 10 mg, especially for diastolic blood pressure15.
Special Populations: Children and Overdose Risks
In children, even relatively low doses of amlodipine (as low as 2.5 mg) can cause significant hypotension and other adverse effects, especially at doses above 10 mg. The risk of clinically important responses, such as bradycardia and hypotension, increases with higher doses, and caution is advised when dosing in pediatric populations.
Pharmacokinetics and Combination Therapy
Pharmacokinetic studies confirm that amlodipine exposure is dose-proportional up to 10 mg daily, and this dose is bioequivalent whether given alone or in fixed-dose combinations with other antihypertensive agents. This supports the use of 10 mg as the maximum recommended daily dose in adults, both as monotherapy and in combination therapy63.
Conclusion
The maximum recommended dosage of amlodipine for adults is 10 mg once daily. This dose provides effective blood pressure control for most patients and is supported by clinical and pharmacokinetic data. Doses above 10 mg are not generally recommended due to increased risk of side effects without additional benefit. In children, lower doses should be used with caution, as adverse effects can occur even at lower amounts. Combination therapy with other antihypertensives may be considered if blood pressure is not controlled at the maximum recommended dose1456.
Sources and full results
Most relevant research papers on this topic