Medications for indigestion
Pro Research Analysisby 
Searched over 200M research papers
Common Medications for Indigestion: Antacids and Acid Neutralizers
Antacids are the most widely used medications for indigestion. They work by neutralizing stomach acid and are considered a first-line treatment for symptoms like heartburn and discomfort. Common antacid ingredients include aluminium hydroxide, magnesium carbonate, and magnesium trisilicate. Some formulations also add simeticone to reduce gas or alginates to protect the esophagus from acid reflux 12. Sodium bicarbonate and potassium bicarbonate, often combined with citric acid, are also used as antacids to relieve acid indigestion and heartburn .
H2-Receptor Antagonists and Proton Pump Inhibitors (PPIs) for Indigestion
For more persistent or severe indigestion, medications that reduce acid production are often used. H2-receptor antagonists, such as Tagamet, Zantac, and Pepcid, work by blocking histamine receptors in the stomach, thereby reducing acid secretion . Proton pump inhibitors (PPIs), including Prilosec, Prevacid, and Nexium, are even more effective at reducing stomach acid and are commonly prescribed for chronic indigestion and acid reflux. These medications have become widely available over the counter, but long-term use has been linked to side effects such as kidney disease, heart disease, infections, and bone fractures .
Herbal and Polyherbal Remedies for Indigestion
Herbal medicines and polyherbal antacid formulations are increasingly popular alternatives for managing indigestion. These remedies use natural plant extracts and are believed to offer synergistic effects and improved safety profiles compared to single-ingredient products. Polyherbal antacids are used globally and are available in various forms, such as powders, tablets, and syrups 810. Specific traditional formulations, like Pancha Harithakadi Churna, combine ingredients such as ginger, fennel, myrobalan, senna, and rock salt, and have shown activity in aiding digestion and relieving symptoms like constipation and bloating . Another example is Jianwei Xiaoshi oral liquid, which has demonstrated effectiveness in improving functional dyspepsia by regulating digestive enzymes and supporting healthy gut microbiota .
Historical and Dietary Approaches
Historically, indigestion has been treated with a variety of substances, including milk and calcium-rich powders, which act as natural antacids. The use of milk and antacids as a mainstay of treatment dates back to the early 20th century and was once a standard approach for peptic diseases .
Considerations and Cautions
While antacids and acid-suppressing medications can provide quick relief, overuse may interfere with normal digestion and nutrient absorption. Raising stomach pH too much can affect the activity of digestive enzymes and alter gut microbial balance, potentially leading to other digestive issues. Some practitioners suggest that, in certain cases, indigestion may be due to insufficient stomach acid rather than excess, and recommend digestive aids like hydrochloric acid or pancreatic enzymes instead .
Conclusion
Medications for indigestion include a range of options from traditional antacids and acid-suppressing drugs to herbal and polyherbal remedies. Each has its benefits and potential drawbacks, and the choice of treatment should consider the underlying cause of symptoms, the severity of indigestion, and individual health needs. For persistent or severe symptoms, consulting a healthcare professional is recommended.
Sources and full results
Most relevant research papers on this topic