Most deadly types of cancer

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Most Deadly Types of Cancer: Global Mortality and Survival Rates

Cancer remains one of the leading causes of death worldwide, with certain types being especially deadly due to high mortality rates and poor long-term survival. The most lethal cancers are often those that are common, aggressive, and difficult to detect early.

Lung, Liver, and Stomach Cancer: Leading Causes of Cancer Death

Lung cancer is consistently identified as the most deadly cancer globally, responsible for the highest number of cancer-related deaths in both men and women. Liver and stomach cancers also rank among the top killers, contributing significantly to global cancer mortality. These three cancers are the leading causes of cancer death in many countries, including China, where lung, liver, and stomach cancers account for the majority of cancer fatalities 12.

Pancreatic, Esophageal, and Brain Cancers: Poorest Prognosis

Pancreatic cancer stands out for its extremely poor prognosis, with a five-year survival rate typically below 10%. Esophageal and liver cancers also have very low survival rates, often less than 20% at five years. Brain cancers, such as glioblastoma multiforme, are also among the most deadly, with limited treatment options and low survival rates 136.

Colorectal Cancer: High Mortality and Global Impact

Colorectal cancer is the second or fourth most deadly cancer worldwide, depending on the region, causing hundreds of thousands of deaths annually. While early-stage colorectal cancer can be curable, late detection and recurrence contribute to its high mortality. The global burden of colorectal cancer is expected to rise in the coming decades 58.

Melanoma: Deadly Skin Cancer

Among skin cancers, melanoma is the most aggressive and deadly form. Although it can be cured if detected early, advanced melanoma is highly resistant to therapy and has a high mortality rate 710.

Ovarian, Stomach, and Myeloma: Other Notably Deadly Cancers

Ovarian cancer, stomach cancer, and myeloma also have low survival rates and are responsible for a significant proportion of cancer deaths. These cancers often lack effective early detection methods, contributing to their lethality .

Cancers with Better Prognosis

In contrast, some common cancers such as prostate and thyroid cancer have much better outcomes, with five-year survival rates approaching 100% .

Conclusion

The most deadly types of cancer worldwide include lung, liver, stomach, pancreatic, esophageal, brain, colorectal, and melanoma. These cancers are characterized by high mortality rates, poor long-term survival, and often limited early detection or effective treatment options. Addressing these deadly cancers requires continued research, improved screening, and better access to effective therapies to reduce their global impact 123567810.

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Most relevant research papers on this topic

Current Cancer Epidemiology

Cancer is the second leading cause of death worldwide, with lung, liver, and stomach cancers being the most deadly, and prostate and thyroid cancers having the best prognosis.

Rigorous JournalHighly Cited

2019·

1030citations

·C. Mattiuzzi et al.

Current cancer burden in China: epidemiology, etiology, and prevention

The Chinese government has made significant efforts to decrease cancer burden through cancer education, screening programs, and addressing modifiable risk factors like infectious agents, smoking, alcohol, obesity, and unhealthy diets.

Rigorous JournalHighly Cited

2022·

162citations

·M. Cao et al.

Deadly cancers need attention, too

Supporting research for common, deadly cancers like ovary, brain, myeloma, stomach, esophageal, liver, and pancreas is crucial, as they account for nearly half of cancer deaths and face underfunded and limited treatment options.

Very Rigorous Journal

2010·

0citations

·C. Printz

Types of Cancer

Herbal therapy shows promising potential in treating various types of cancer, as it is free from side effects and can potentially improve survival rates.

2019·

2citations

·B. Koul

Colorectal cancer (CRC) is considered as the world’s fourth most deadly cancer with an estimated death of 900,000 annually. Besides ageing and lifestyle, dietary habit also contributes to the onset and the progress of this disease

New targeted therapies targeting DNA damage checkpoint control may offer a promising approach for treating colorectal cancer with reduced side effects and improved efficacy.

2020·

0citations

·Partha Mitra

miR-221/222 Target the DNA Methyltransferase MGMT in Glioma Cells

miR-221/222 may negatively impact MGMT expression in glioma cells, potentially worsening GBM prognosis by impairing cell repair of genetic damage.

In Vitro StudyRigorous JournalHighly Cited

2013·

97citations

·C. Quintavalle et al.

m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade

FTO plays a crucial role in promoting melanoma tumorigenesis and anti-PD-1 resistance, and inhibiting FTO with anti-PD-1 blockade may reduce resistance to immunotherapy in melanoma.

In Vitro StudyHighly Cited

2019·

486citations

·Seungwon Yang et al.

Colorectal Cancer: A Review of Carcinogenesis, Global Epidemiology, Current Challenges, Risk Factors, Preventive and Treatment Strategies

Colorectal cancer is a highly lethal cancer with high recurrence rates and drug resistance, requiring improved preventive and treatment strategies.

Literature ReviewRigorous JournalHighly Cited

2022·

495citations

·Md. Sanower Hossain et al.

Lung Cancer Detection and Classification Using Machine Learning Algorithm(CNN)

CNN models are more accurate in diagnosing lung cancers than traditional structures, aiding in early detection and treatment.

2024·

4citations

·Shivappa M. Metagar et al.

Detection of Skin Cancer Using SVM, Random Forest and kNN Classifiers

The SVM classifier provides better results for skin cancer detection compared to kNN, Random Forest, and kNN classifiers using watershed segmentation and extracted features.

Highly Cited

2019·

211citations

·A. Murugan et al.

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