How much DHEA should I take daily?
Searched over 200M research papers
Research Analysis by Consensus
Consensus Meter
Optimal Daily Dosage of DHEA: Insights from Research
Introduction to DHEA Supplementation
Dehydroepiandrosterone (DHEA) is a steroid hormone that declines with age and is often supplemented to counteract age-related deficiencies. Determining the optimal daily dosage of DHEA is crucial for maximizing benefits while minimizing potential risks.
Recommended Dosage for Elderly Individuals
Several studies have investigated the effects of DHEA supplementation in elderly populations. Research indicates that a daily dose of 50 mg of DHEA is generally safe and effective for elderly individuals. This dosage has been shown to reestablish youthful levels of DHEA and its sulfate (DHEAS) without causing harmful accumulation of steroids or significant adverse effects . Additionally, a 50 mg daily dose over one year improved bone turnover, skin hydration, and libido in older women.
Dosage for Postmenopausal Women
For postmenopausal women, a daily dose of 50 mg of DHEA has been found to be safe over a 52-week period. This dosage did not significantly affect lipid profiles, insulin sensitivity, or the endometrium, making it a viable option for improving sexual function and overall well-being in this demographic.
Higher Dosages and Their Effects
Higher dosages, such as 100 mg daily, have also been explored. A study administering 100 mg of DHEA daily for six months observed increases in circulating sex steroids, body composition improvements, and muscle strength in older adults. However, it is important to note that such higher doses should be approached with caution due to the potential for increased androgenic effects.
Lower Dosages and Individual Variability
Interestingly, some research suggests that lower doses, ranging from 1.25 mg to 12.5 mg, may be optimal for certain individuals. This study found that these lower doses maximized the increase in normal cell telomere length and provided various health benefits without the risks associated with higher doses. This highlights the importance of individual variability in response to DHEA supplementation.
Special Considerations for Specific Conditions
In patients with Addison's disease, a daily dose of 50 mg of DHEA improved mood and fatigue without significant adverse effects, suggesting its potential role in managing this condition. Additionally, for women undergoing in vitro fertilization (IVF), a daily dose of 75 mg of DHEA improved ovarian reserves and live birth rates, indicating its beneficial effects in reproductive health.
Conclusion
The optimal daily dosage of DHEA varies depending on individual health status and specific conditions. For general anti-aging purposes in elderly individuals and postmenopausal women, a daily dose of 50 mg is widely supported by research. However, lower doses may be more appropriate for some individuals, and higher doses should be used cautiously. Always consult with a healthcare provider before starting DHEA supplementation to determine the most suitable dosage for your needs.
Sources and full results
Most relevant research papers on this topic