How much Goldenseal should I take daily?
Pro Research Analysisby 
Searched over 200M research papers
Consensus Meter
Daily Dosage of Goldenseal: Insights from Research
Recommended Daily Dosage of Goldenseal
Goldenseal Supplementation in Clinical Studies
Research on the supplementation of Goldenseal (Hydrastis canadensis) provides valuable insights into its safe and effective daily dosage. In a study examining the effects of Goldenseal on digoxin pharmacokinetics, participants were administered a standardized dose of 3210 mg daily for 14 days. This dosage was found to have minimal impact on the pharmacokinetics of digoxin, suggesting that it is a safe amount for short-term use.
Impact on CYP3A Activity
Another study focused on the influence of Goldenseal on CYP3A activity, a crucial enzyme in drug metabolism. Participants in this study received Goldenseal supplementation at a dose of 1140 mg twice daily (totaling 2280 mg per day) for 14 days. The results indicated significant inhibition of CYP3A activity, highlighting the potential for herb-drug interactions when Goldenseal is taken with other medications metabolized by this enzyme.
Pharmacokinetics of Indinavir
Further research investigated the effect of Goldenseal on the pharmacokinetics of indinavir, a drug metabolized by CYP3A4. In this study, participants were given 1140 mg of Goldenseal root twice daily for 14 days. The findings showed no significant changes in the pharmacokinetics of indinavir, suggesting that this dosage is unlikely to cause adverse interactions with drugs metabolized by CYP3A4.
Conclusion
Based on the available research, a daily dosage of Goldenseal ranging from 2280 mg to 3210 mg appears to be safe for short-term use in healthy adults. However, it is important to consider potential interactions with other medications, particularly those metabolized by CYP3A enzymes. As always, it is advisable to consult with a healthcare provider before starting any new supplement regimen.
Sources and full results
Most relevant research papers on this topic