Multi collagen
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Advances in Multi-Collagen Research and Applications
Introduction to Multi-Collagen Structures
Collagen, the most abundant structural protein in mammals, plays a crucial role in connective tissues such as skin, tendon, bone, and cartilage. Its complex biosynthesis involves numerous intracellular and extracellular steps, resulting in a multi-hierarchical fibrous architecture that significantly influences its bioactivity 1. This multi-level structure is essential for various biological functions, including tissue scaffolding, cell adhesion, and tissue repair 59.
Multi-Hierarchical Collagen Aggregates
Multi-level collagen aggregates encompass structures ranging from molecular collagen to advanced aggregates and tissues. These aggregates are prepared through various methods, and their properties are closely linked to their structural characteristics. The relationship between structure and function is critical for their application in the biomedical field, offering a broad range of potential uses 4.
Biomedical Applications of Collagen-Based Biomaterials
Collagen-based biomaterials have garnered significant attention due to their excellent properties, such as low immunogenicity, biodegradability, biocompatibility, and hydrophilicity. These materials are used in various biomedical applications, including skin substitutes, bone repair, tendon repair, cartilage repair, neural repair, and drug delivery systems. However, collagen's poor physical and chemical properties necessitate modifications during the preparation process to enhance its mechanical strength, thermostability, and resistance to enzymatic degradation 1.
Multi-Channel Collagen Gels for Tissue Engineering
Multi-channel collagen gels (MCCGs) are promising candidates for three-dimensional tissue engineering. These gels, formed by the dialysis of an acidic collagen solution in a neutral buffer, feature unique structures with capillaries ranging from tens to hundreds of micrometers in diameter. The formation of MCCGs involves viscoelastic phase separation followed by gelation, making them suitable for mimicking natural tissue scaffolds 2.
Multifilament Collagen Fiber Bundles
Collagen multifilament bundles, prepared by multi-pin contact drawing of an entangled polymer solution, exhibit tendon-like structures and mechanical performance. These bundles are hydrated to promote the assembly of collagen fibrils, resulting in a structure that closely mimics natural tendons. The ultimate tensile strength and Young's modulus of these bundles can be enhanced through ultraviolet C (UVC) crosslinking, making them suitable for applications requiring high mechanical performance 3.
Detection of Collagen in Bone Health Assessment
Collagen is a critical biomarker for assessing bone health, particularly in the context of osteoporosis. Multi-wavelength photoacoustic (MWPA) techniques enable the noninvasive measurement of collagen content in bones. This method uses pulsed laser light to induce photoacoustic signals, facilitating the visualization of collagen and its correlation with bone density. MWPA has shown promising results in both numerical simulations and ex vivo experiments, highlighting its potential for clinical applications 6.
Synthetic Collagen Mimics
Synthetic collagen mimics, such as collagen mimetic peptides (CMPs), replicate the multi-hierarchical self-assembly of natural collagen. These peptides undergo a series of assembly steps, from peptide chains to triple helices, nanofibres, and finally hydrogels. CMPs have been instrumental in studying the structure and stabilization of collagen, as well as its interactions with cell-surface receptors. These mimics offer valuable insights into collagen's role in connective tissue diseases and its potential for biomedical applications 710.
Conclusion
The research on multi-collagen structures and their applications continues to evolve, offering promising advancements in biomedical fields. From multi-hierarchical aggregates to synthetic collagen mimics, these materials hold significant potential for tissue engineering, bone health assessment, and various therapeutic applications. The ongoing development and modification of collagen-based biomaterials will likely lead to even broader applications and improved outcomes in the future.
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Most relevant research papers on this topic
Recent advances of collagen-based biomaterials: Multi-hierarchical structure, modification and biomedical applications.
Collagen-based biomaterials show promise for biomedical applications, but require modification for improved mechanical strength, thermostability, and resistance to enzymes.
Highly CitedFormation of Multi-Channel Collagen Gels Investigated Using Particle Tracking Microrheology.
Multi-channel collagen gels (MCCG) form through the formation of transient structures during viscoelastic phase separation and gelation, offering potential as biomimetic scaffolds for tissue engineering applications.
Multifilament Collagen Fiber Bundles with Tendon-like Structure and Mechanical Performance.
This study successfully creates collagen multifilament bundles with a tendon-like structure and mechanical performance using only collagen molecules, offering tunability in tensile properties without chemical additives.
Multi-level collagen aggregates and their applications in biomedical applications
Multi-level collagen aggregates and their modified products have a broad range of applications in biomedical fields, with potential for greater biomedical material development than collagen alone.
Literature ReviewCollagens at a glance
Tissue scaffolding protein, collagen plays a crucial role in tissue repair and maintenance, and is involved in various diseases and angiogenesis.
Highly CitedDetection of collagen by multi-wavelength photoacoustic analysis as a biomarker for bone health assessment
Multi-wavelength photoacoustic analysis (MWPA) effectively detects collagen content in bone, offering a potential biomarker for bone health assessment.
In Vitro StudyMulti-hierarchical self-assembly of a collagen mimetic peptide from triple helix to nanofibre and hydrogel.
This study successfully replicates the multi-hierarchical self-assembly of collagen through triple helix, nanofibres, and hydrogel, offering potential biomedical applications in tissue engineering.
Highly CitedCollagen VI at a glance
Collagen VI plays a crucial role in various tissues and conditions, preserving biomechanical properties and playing a cytoprotective role in various cells.
Highly CitedThe collagen family.
Collagens play structural roles in tissues and regulate cell proliferation, migration, and differentiation through their interaction with receptor families.
Highly CitedSynthetic collagen mimics: self-assembly of homotrimers, heterotrimers and higher order structures.
Collagen mimetic peptides (CMPs) have helped unravel the mystery of collagen's complex structure and assembly, aiding in understanding connective tissue diseases and protein interactions.
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