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These studies suggest that NAD IV therapy can have side effects, particularly anaphylactoid reactions in patients with atopic diseases.
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Nicotinamide adenine dinucleotide (NAD) is a coenzyme found in all living cells, playing a crucial role in energy metabolism and cellular function. Intravenous (IV) NAD therapy has gained attention for its potential benefits in treating various conditions, including neurodegenerative diseases like Parkinson's Disease (PD) and age-related conditions. However, understanding the side effects associated with NAD IV therapy is essential for its safe application.
While NAD IV therapy is generally considered safe, some side effects have been reported. These include nausea, fatigue, headaches, and abdominal discomfort. These side effects are typically mild and transient, resolving shortly after the infusion is completed .
A significant concern with IV therapies, including NAD, is the potential for anaphylactoid reactions. Although specific data on NAD IV therapy is limited, studies on similar IV treatments, such as N-acetylcysteine (NAC), have shown a high incidence of anaphylactoid reactions. In a study of 173 patients receiving IV-NAC, 44.5% experienced anaphylactoid reactions, with symptoms including nausea, vomiting, flushing, bronchospasm, vertigo, skin rash, and hypotension. This suggests that similar reactions could potentially occur with NAD IV therapy, especially in patients with a history of atopic diseases.
A case report on a 59-year-old male with Parkinson's Disease (PD) treated with IV NAD therapy highlighted some specific side effects. The patient received a protocol of NAD+ over six days, followed by sublingual NAD+ tablets. While the therapy significantly reduced tremors, no severe adverse effects were reported during the treatment period. This suggests that, at least in the context of PD, NAD IV therapy may have a favorable side effect profile.
NAD IV therapy shows promise for treating various conditions, including neurodegenerative and age-related diseases. However, like any medical treatment, it is not without potential side effects. Common side effects include mild symptoms such as nausea and headaches, while more severe reactions like anaphylactoid responses, although not well-documented for NAD, could be a concern based on similar IV treatments. Further research and clinical trials are necessary to fully understand the safety profile of NAD IV therapy and to establish protocols that minimize risks while maximizing therapeutic benefits.
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