Natural supplements for lowering cholesterol
Pro Research Analysisby 
Searched over 200M research papers
Key Natural Supplements for Lowering Cholesterol
Several natural supplements have been studied for their ability to lower cholesterol, especially for people seeking alternatives to statin medications. The most researched and effective options include red yeast rice, plant sterols and stanols, policosanol, bergamot, artichoke extract, flaxseed, garlic, and certain fibers and polyphenols 12345789+1 MORE.
Red Yeast Rice and Monacolin K
Red yeast rice (RYR) is widely recognized as one of the most effective natural supplements for lowering cholesterol. Its active ingredient, monacolin K, can reduce LDL cholesterol by 15–25% within 6 to 8 weeks, with similar effects on total cholesterol and other lipid markers. RYR works in a way similar to statins but generally has fewer side effects, making it suitable for people with mild to moderate hypercholesterolemia who do not have additional cardiovascular risk factors 2489.
Plant Sterols and Stanols
Plant sterols and stanols are naturally occurring compounds found in certain foods and supplements. They lower cholesterol by blocking its absorption in the intestines. These supplements can reduce LDL cholesterol by 3–25%, especially in people with high cholesterol 1510.
Policosanol
Policosanol, derived from sugar cane, has shown effectiveness in lowering cholesterol levels, with some studies suggesting results comparable to statin drugs but without the risk of liver damage. It is considered safe and can be recommended for those seeking natural alternatives 34.
Bergamot and Artichoke Extract
Bergamot extract and artichoke leaf extract have both demonstrated cholesterol-lowering effects. When combined with other supplements like red yeast rice, they can further improve lipid profiles, including reductions in LDL cholesterol and triglycerides, and increases in HDL cholesterol 249.
Flaxseed
Flaxseed is another natural supplement that may help lower cholesterol. It is rich in omega-3 fatty acids and fiber, both of which contribute to improved cholesterol levels 25.
Garlic
Garlic supplements have shown modest cholesterol-lowering effects in some studies, though results are inconsistent. Aged garlic extract may be less effective, but garlic remains a popular choice for those seeking natural options 1257.
Soluble Fibers and Polyphenols
Soluble fibers (such as those found in oats, psyllium, and certain fruits) and polyphenol extracts (from sources like green tea and berberine) can also help reduce cholesterol by enhancing bile acid excretion and inhibiting cholesterol absorption 157.
Effectiveness Compared to Statins
While some natural supplements can lower cholesterol, their effects are generally more modest and less predictable than statin medications. Clinical trials have shown that statins reduce LDL cholesterol much more effectively than most supplements. In some studies, supplements like fish oil, cinnamon, garlic, turmeric, plant sterols, and red yeast rice did not show significant benefits compared to placebo, highlighting the need for realistic expectations and further research 67.
Safety, Quality, and Considerations
Natural supplements are generally safe for most people, but their effectiveness can vary based on the product's quality and composition. Red yeast rice, for example, is only effective if it contains sufficient monacolin K. There are also concerns about the lack of regulation and quality control in the supplement industry, so it is important to choose reputable brands and consult healthcare providers before starting any new supplement, especially for those with underlying health conditions or those already taking medications 278.
Conclusion
Natural supplements such as red yeast rice, plant sterols, policosanol, bergamot, artichoke extract, flaxseed, garlic, and soluble fibers can help lower cholesterol, particularly for individuals who cannot tolerate statins or prefer nonprescription options. However, their cholesterol-lowering effects are generally less pronounced than those of statins, and results can be inconsistent. It is important to use these supplements under medical supervision and as part of a broader approach to heart health, including diet and lifestyle changes 12345789+1 MORE.
Sources and full results
Most relevant research papers on this topic