Nausea from zinc
Searched over 200M research papers
Summary
10 papers analyzed
These studies suggest that zinc supplementation can cause nausea and other gastrointestinal discomforts, particularly at higher doses or in specific formulations.
Not a yes or no question
To use the Consensus Meter, try asking a simple yes or no question
Research summarized with Copilot
Beta20 papers analyzed
Nausea from Zinc: A Comprehensive Review
Introduction to Zinc and Its Uses
Zinc is an essential mineral involved in numerous aspects of cellular metabolism, immune function, and protein synthesis. It is commonly used in supplements and medications for various health conditions, including the common cold, diarrhea, and dysmenorrhea. However, zinc intake, especially in high doses, can lead to adverse effects, including nausea.
Zinc Toxicity and Nausea
High Zinc Intake and Gastrointestinal Symptoms
Excessive zinc intake can lead to overt toxicity symptoms such as nausea, vomiting, and epigastric pain. These symptoms are particularly evident when zinc is consumed in amounts significantly higher than the Recommended Dietary Allowance (RDA). For instance, a study on healthy volunteers taking 150 mg of zinc daily reported a high incidence of gastrointestinal discomfort, including nausea and vomiting, especially among lower-weight individuals.
Acute Zinc Poisoning
Acute zinc poisoning can result from accidental ingestion or exposure to high levels of zinc. A case study of a 24-year-old man who ingested liquid zinc chloride highlighted severe local and systemic effects, including nausea and vomiting. Similarly, a patient on home hemodialysis experienced acute nausea and vomiting due to zinc contamination in the water used for dialysis.
Zinc Supplementation in Clinical Trials
Zinc and Childhood Diarrhea
Zinc supplementation is recommended for managing childhood diarrhea. However, studies have shown that zinc treatment can increase the risk of vomiting. A randomized clinical trial found that children receiving zinc sulfate tablets had a 14% higher risk of vomiting compared to those receiving a placebo. Another study noted that the unpleasant taste of zinc often led to nausea and vomiting in children.
Zinc for Dysmenorrhea
In a trial investigating zinc sulfate for dysmenorrhea, no significant differences in nausea and vomiting were observed between the treatment and placebo groups. This suggests that while zinc can be effective for pain management, it does not necessarily exacerbate gastrointestinal symptoms in this context.
Zinc for Respiratory Infections
Zinc is also used to prevent and treat respiratory tract infections. However, its use is associated with non-serious adverse events such as nausea and mouth irritation. A systematic review found that zinc formulations increased the risk of nausea compared to placebo. Another study on zinc acetate lozenges reported nausea in users, with no significant benefit in treating upper respiratory tract infections.
Conclusion
While zinc is beneficial for various health conditions, its intake, especially in high doses, can lead to gastrointestinal side effects, including nausea. Clinical trials and case studies consistently report nausea as a common adverse effect of zinc supplementation. Therefore, individuals using zinc supplements should be aware of these potential side effects and consult healthcare providers to determine appropriate dosages.
Sources and full results
Most relevant research papers on this topic
