Neutrophils normal range in percentage

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Normal Range of Neutrophils in Percentage

Introduction to Neutrophils and Their Importance

Neutrophils are a type of white blood cell crucial for the immune system, playing a key role in defending the body against infections. Understanding the normal range of neutrophils is essential for diagnosing and monitoring various health conditions.

Normal Neutrophil Percentage in Adults

General Adult Population

In healthy adults, the percentage of neutrophils typically ranges from 40% to 60% of the total white blood cell count. This range is considered normal and indicates a well-functioning immune system 12.

Gender Differences in Neutrophil Counts

Research has shown that there are significant differences in neutrophil counts between males and females. On average, women have higher neutrophil counts compared to men, with an increase of approximately 660/mm³ . This difference is not influenced by the use of oral contraceptives among women.

Diurnal Variation in Neutrophil Counts

Neutrophil counts also exhibit diurnal variation, being higher in the afternoon compared to the morning by about 500/mm³ . This variation should be considered when interpreting neutrophil counts in clinical settings.

Neutrophil Percentage in Newborns and Infants

Cord Blood Neutrophil Percentage

In newborns, the percentage of neutrophils forming erythrocyte-antibody-complement complexes (EAC) ranges from 84% to 100%, with a mean of 95% . This high percentage indicates a robust initial immune response in newborns.

Very-Low-Birth-Weight Neonates

For very-low-birth-weight (VLBW) neonates, the reference ranges for neutrophil counts differ significantly from those of older and larger neonates. The normal range for total neutrophil values (ATN) in VLBW neonates between birth and 28 days is broader, with lower boundaries adjusted to reflect developmental differences . Specifically, the upper and lower boundaries for ATN values between 61 hours and 28 days are 6000/mm³ and 1100/mm³, respectively .

Conclusion

Understanding the normal range of neutrophils in different populations is crucial for accurate diagnosis and treatment. In adults, the normal range is 40% to 60%, with variations based on gender and time of day. In newborns, particularly VLBW neonates, the reference ranges are adjusted to account for developmental differences. These insights are essential for healthcare providers to make informed clinical decisions.

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Most relevant research papers on this topic

What is the normal value of the neutrophil-to-lymphocyte ratio?

Normal neutrophil-to-lymphocyte ratio values in an adult, non-geriatric, population in good health are between 0.78 and 3.53.

Observational StudyRigorous JournalHighly Cited

2017·

564citations

·P. Forget et al.

Normal haematological values: sex difference in neutrophil count.

Neutrophil counts are significantly higher in women than in men, and both men and women have higher neutrophil counts in the afternoon compared to the morning, with a correlation observed between neutrophil and monocyte counts.

Observational StudyHighly Cited

1975·

125citations

·B. Bain et al.

Complement and Fc Receptors on Cord Blood and Adult Neutrophils

The average percentage of complement and Fc receptors on neutrophils in cord blood of normal infants and adult peripheral blood is identical.

Observational Study

1977·

15citations

·S. Pross et al.

Revised reference ranges for circulating neutrophils in very-low-birth-weight neonates.

Normal preterm VLBW neonates have circulating neutrophil reference ranges that differ significantly from larger, older neonates, highlighting the effects of development on neutrophil dynamics.

Observational StudyHighly Cited

1994·

205citations

·Anna Mouzinho et al.

The neonatal blood count in health and disease. I. Reference values for neutrophilic cells.

Neutropenia in the first 72 hours of life is highly predictive of bacterial disease, while abnormal I:T proportions are less specific, and interpretation should consider both infectious and noninfectious perinatal events.

Observational StudyHighly Cited

1979·

801citations

·B. Manroe et al.

Expected ranges for blood neutrophil concentrations of neonates: the Manroe and Mouzinho charts revisited

The Manroe and Mouzinho charts have higher upper limits for blood neutrophil concentrations in neonates at high altitude, indicating that they may be inappropriate for high-altitude conditions.

Observational StudyHighly Cited

2008·

158citations

·N. Schmutz et al.

Neutrophil volume distribution width: a new automated hematologic parameter for acute infection.

The neutrophil volume distribution width (NDW) shows potential as an additional indicator for diagnosing acute infection, with a 100% specificity and 69% sensitivity achieved using an NDW cutoff of 23.

Observational Study

2009·

66citations

·F. Chaves et al.

Neutrophil Counts and Initial Presentation of 12 Cardiovascular Diseases

Neutrophil counts are strongly associated with the incidence of some cardiovascular diseases, but not others, even within the normal range, suggesting differing underlying mechanisms across CVDs.

Observational StudyRigorous JournalHighly Cited

2017·

86citations

·A. Shah et al.

Benign ethnic neutropenia: what is a normal absolute neutrophil count?

The lower limit for acceptable absolute neutrophil counts should be readjusted downward for all ethnic groups, as benign ethnic neutropenia suggests that the key issue is bone marrow production of normally functioning cells.

Highly Cited

1999·

239citations

·Theresa B. Haddy et al.

Neutrophil count and percentage: potential independent prognostic indicators for advanced cancer patients in a palliative care setting

High pretreatment or newly increased neutrophil count and percentage are independent prognostic factors for decreased overall survival in advanced cancer patients undergoing palliative care.

Observational StudyRigorous Journal

2017·

11citations

·Weiwei Zhao et al.

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