Neutrophils normal range percentage

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Normal Range of Neutrophils Percentage

Introduction to Neutrophils and Their Importance

Neutrophils are a type of white blood cell crucial for the immune system, playing a key role in defending the body against infections. Understanding the normal range of neutrophils is essential for diagnosing and managing various health conditions.

Normal Neutrophil Percentage in Adults

The normal range of neutrophils in a healthy adult population typically falls between 40% and 70% of the total white blood cell count. This range can vary slightly based on factors such as age, sex, and ethnicity.

Sex Differences in Neutrophil Counts

Research indicates that there are significant differences in neutrophil counts between males and females. On average, women have higher neutrophil counts compared to men, with a difference of approximately 0.66 x 10^9/L (660/mm^3) . This difference is not influenced by the use of oral contraceptives among women.

Diurnal Variation in Neutrophil Counts

Neutrophil counts also exhibit diurnal variation, being higher in the afternoon compared to the morning by about 0.50 x 10^9/L (500/mm^3) . This variation should be considered when interpreting neutrophil counts in clinical settings.

Neutrophil Counts in Special Populations

Very-Low-Birth-Weight Neonates

In very-low-birth-weight (VLBW) neonates, the reference ranges for neutrophil counts differ significantly from those of older and larger neonates. For VLBW neonates, the normal range of absolute total neutrophil (ATN) values between 61 hours and 28 days of age is between 1100/mm^3 and 6000/mm^3 . This highlights the impact of developmental stages on neutrophil dynamics.

Ethnic Variations in Neutrophil Counts

Ethnic background also influences neutrophil counts. For instance, healthy Caucasian and Asian populations generally have absolute neutrophil counts (ANC) ranging from 1.5 to 7.0 x 10^9/L. However, individuals of African descent may have lower normal neutrophil counts, with ANC <1.5 x 10^9/L occurring in about 4.5% of black participants in one U.S. survey .

Conclusion

The normal range of neutrophil percentages in adults is generally between 40% and 70% of the total white blood cell count. This range can vary based on sex, time of day, developmental stage, and ethnic background. Understanding these variations is crucial for accurate diagnosis and management of health conditions related to neutrophil counts.

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Most relevant research papers on this topic

What is the normal value of the neutrophil-to-lymphocyte ratio?

Normal neutrophil-to-lymphocyte ratio values in an adult, non-geriatric, population in good health are between 0.78 and 3.53.

Observational StudyRigorous JournalHighly Cited

2017·

564citations

·P. Forget et al.

Normal haematological values: sex difference in neutrophil count.

Neutrophil counts are significantly higher in women than in men, and both men and women have higher neutrophil counts in the afternoon compared to the morning, with a correlation observed between neutrophil and monocyte counts.

Observational StudyHighly Cited

1975·

125citations

·B. Bain et al.

Revised reference ranges for circulating neutrophils in very-low-birth-weight neonates.

Normal preterm VLBW neonates have circulating neutrophil reference ranges that differ significantly from larger, older neonates, highlighting the effects of development on neutrophil dynamics.

Observational StudyHighly Cited

1994·

205citations

·Anna Mouzinho et al.

Complement and Fc Receptors on Cord Blood and Adult Neutrophils

The average percentage of complement and Fc receptors on neutrophils in cord blood of normal infants and adult peripheral blood is identical.

Observational Study

1977·

15citations

·S. Pross et al.

Prevalence of Neutropenia in a Cohort of Adult Population in Qatar: Relation to Other Hematological Parameters and Anthropometric Data

Neutropenia is prevalent in 10.7% of non-prospective Arab blood donors, with a higher prevalence in females and a lower prevalence in males.

Observational Study

2020·

1citation

·M. Yassin et al.

Expected ranges for blood neutrophil concentrations of neonates: the Manroe and Mouzinho charts revisited

The Manroe and Mouzinho charts have higher upper limits for blood neutrophil concentrations in neonates at high altitude, indicating that they may be inappropriate for high-altitude conditions.

Observational StudyHighly Cited

2008·

158citations

·N. Schmutz et al.

Neutrophil volume distribution width: a new automated hematologic parameter for acute infection.

The neutrophil volume distribution width (NDW) shows potential as an additional indicator for diagnosing acute infection, with a 100% specificity and 69% sensitivity achieved using an NDW cutoff of 23.

Observational Study

2009·

66citations

·F. Chaves et al.

Neutrophil and band counts in the diagnosis of neonatal infections.

Newborn infants with bacterial infections have normal neutrophil counts, but increased band neutrophils, making this hematologic technique crucial for diagnosing sepsis in newborns.

Observational StudyHighly Cited

1974·

122citations

·Gregory I. Akenzua et al.

Neutrophil Counts and Initial Presentation of 12 Cardiovascular Diseases

Neutrophil counts are strongly associated with the incidence of some cardiovascular diseases, but not others, even within the normal range, suggesting differing underlying mechanisms across CVDs.

Observational StudyRigorous JournalHighly Cited

2017·

86citations

·A. Shah et al.

The neonatal blood count in health and disease. I. Reference values for neutrophilic cells.

Neutropenia in the first 72 hours of life is highly predictive of bacterial disease, while abnormal I:T proportions are less specific, and interpretation should consider both infectious and noninfectious perinatal events.

Observational StudyHighly Cited

1979·

801citations

·B. Manroe et al.

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