Nicotinamide adenine dinucleotide (NAD+) intravenous therapy benefits
Pro Research Analysisby 
Searched over 200M research papers
NAD+ Intravenous Therapy: Safety and General Benefits
Research shows that increasing nicotinamide adenine dinucleotide (NAD+) levels can help slow age-related disease progression and promote healthier aging. Intravenous (IV) administration of NAD+ or its precursors, such as nicotinamide mononucleotide (NMN), has been found to be safe in both animal and human studies, with no significant adverse effects on vital signs or organ function markers 15. These therapies efficiently raise blood NAD+ levels, which is important for cellular energy, DNA repair, and metabolic health 1610.
Cardiometabolic Health: Cholesterol, Triglycerides, and Blood Pressure
IV NAD+ therapy and NMN supplementation have shown significant benefits for cardiometabolic health. Studies in healthy adults and those at risk for age-related conditions found that NAD+ augmentation can lower blood triglyceride levels, total cholesterol, LDL cholesterol, and diastolic blood pressure 19. These changes suggest a potential role for NAD+ therapy in preventing or treating conditions like fatty liver, diabetes, and cardiovascular disease 1910.
Heart Failure and Cardiac Function
NAD+ is crucial for heart cell energy metabolism and redox balance. In patients with heart failure, IV NAD+ therapy for seven days improved markers of cardiac function, reduced oxidative stress, and lessened endothelial injury compared to placebo, although some improvements were not statistically significant . Preclinical and clinical studies support the idea that boosting NAD+ levels can protect the heart, improve mitochondrial function, and reduce inflammation and oxidative stress, which are key factors in heart failure and other cardiac diseases 3810.
Neuroprotection and Brain Health
Animal studies show that IV NMN can enter the brain, increase NAD+ levels, and protect against brain damage after ischemic stroke by reducing infarct size and supporting neuronal survival 57. These findings suggest that NAD+ therapy may have neuroprotective effects, especially in conditions involving acute brain injury or neurodegeneration 57.
Anti-Inflammatory and Regenerative Effects
Combining IV NAD+ with umbilical cord-derived stem cells (UCSCs) has been shown to enhance tissue repair, reduce inflammation, and lower oxidative stress. This combination activates sirtuins, proteins involved in cellular health and longevity, and may further boost the regenerative and anti-inflammatory benefits of NAD+ therapy .
Mechanisms and Metabolism of IV NAD+ Therapy
During IV infusion, NAD+ is rapidly metabolized and removed from plasma, with its breakdown products excreted in urine. This rapid metabolism highlights the need for optimized dosing strategies to maintain therapeutic NAD+ levels . NAD+ therapy works by supporting energy production, DNA repair, and reducing chronic oxidative stress and inflammation, which are common in aging and degenerative diseases 610.
Safety and Risks
Most studies report that IV NAD+ and its precursors have a favorable safety profile with minimal acute toxicity 1569. However, long-term safety data in humans are still limited, and potential risks such as accumulation of toxic metabolites or effects on tumor growth require further investigation .
Conclusion
IV NAD+ therapy and its precursors, especially NMN, are safe and show promise for improving cardiometabolic health, supporting heart and brain function, and reducing inflammation and oxidative stress. While early results are encouraging, more large-scale and long-term clinical trials are needed to fully understand the benefits and risks of NAD+ intravenous therapy in humans.
Sources and full results
Most relevant research papers on this topic